12 items (Poecilia reticulata) - STRING interaction network

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Your Input:
	ENSPREP00000025366	ThiF domain-containing protein. (53 aa)
	LOC103464541	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family. (1012 aa)
	LOC103467931	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (768 aa)
	mocs3	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (459 aa)
	atg7	ATG7 autophagy related 7 homolog (S. cerevisiae). (720 aa)
	uba6	Ubiquitin like modifier activating enzyme 6. (1044 aa)
	uba2	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (599 aa)
	nae1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (533 aa)
	sae1	SUMO1 activating enzyme subunit 1. (344 aa)
	LOC103465053	Ubiquitin-like modifier activating enzyme 3. (442 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (462 aa)
	uba5	Ubiquitin-like modifier activating enzyme 5. (400 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000025366	nae1	ENSPREP00000025366	ENSPREP00000033169	ThiF domain-containing protein.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.412
ENSPREP00000025366	sae1	ENSPREP00000025366	ENSPREP00000029023	ThiF domain-containing protein.	SUMO1 activating enzyme subunit 1.	0.980
LOC103464541	LOC103465053	ENSPREP00000005578	ENSPREP00000026705	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier activating enzyme 3.	0.664
LOC103464541	LOC103467931	ENSPREP00000005578	ENSPREP00000028974	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.902
LOC103464541	UBA3	ENSPREP00000005578	ENSPREP00000006714	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin like modifier activating enzyme 3.	0.664
LOC103464541	atg7	ENSPREP00000005578	ENSPREP00000009567	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	ATG7 autophagy related 7 homolog (S. cerevisiae).	0.750
LOC103464541	mocs3	ENSPREP00000005578	ENSPREP00000000990	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]	0.408
LOC103464541	uba5	ENSPREP00000005578	ENSPREP00000013586	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier activating enzyme 5.	0.743
LOC103464541	uba6	ENSPREP00000005578	ENSPREP00000009413	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin like modifier activating enzyme 6.	0.907
LOC103465053	LOC103464541	ENSPREP00000026705	ENSPREP00000005578	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	0.664
LOC103465053	LOC103467931	ENSPREP00000026705	ENSPREP00000028974	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.664
LOC103465053	UBA3	ENSPREP00000026705	ENSPREP00000006714	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin like modifier activating enzyme 3.	0.900
LOC103465053	atg7	ENSPREP00000026705	ENSPREP00000009567	Ubiquitin-like modifier activating enzyme 3.	ATG7 autophagy related 7 homolog (S. cerevisiae).	0.757
LOC103465053	mocs3	ENSPREP00000026705	ENSPREP00000000990	Ubiquitin-like modifier activating enzyme 3.	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]	0.486
LOC103465053	nae1	ENSPREP00000026705	ENSPREP00000033169	Ubiquitin-like modifier activating enzyme 3.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.989
LOC103465053	sae1	ENSPREP00000026705	ENSPREP00000029023	Ubiquitin-like modifier activating enzyme 3.	SUMO1 activating enzyme subunit 1.	0.444
LOC103465053	uba5	ENSPREP00000026705	ENSPREP00000013586	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 5.	0.774
LOC103465053	uba6	ENSPREP00000026705	ENSPREP00000009413	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin like modifier activating enzyme 6.	0.664
LOC103467931	LOC103464541	ENSPREP00000028974	ENSPREP00000005578	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	0.902
LOC103467931	LOC103465053	ENSPREP00000028974	ENSPREP00000026705	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier activating enzyme 3.	0.664