STRINGSTRING
xpa xpa LOC103464091 LOC103464091 Arhgap30 Arhgap30 parp1 parp1 ENSPREP00000001630 ENSPREP00000001630 Nfatc4 Nfatc4 actr5 actr5 LOC103462295 LOC103462295 LOC103466877 LOC103466877 LOC103464907 LOC103464907 mc1r mc1r sirt1 sirt1 opn3 opn3 dhx36 dhx36 LOC103461212 LOC103461212 polk polk men1 men1 bcl2 bcl2 ddb1 ddb1 kdm1a kdm1a msh2 msh2 ube2b ube2b primpol primpol ENSPREP00000007854 ENSPREP00000007854 ro60 ro60 tp53i13 tp53i13 tmem161a tmem161a aqp1 aqp1 ENSPREP00000010780 ENSPREP00000010780 dtl dtl IL12B IL12B crebbp crebbp ppid ppid zranb3 zranb3 rev1 rev1 eif2s1 eif2s1 BAX BAX ercc1 ercc1 LOC103480536 LOC103480536 ddb2 ddb2 LOC103481692 LOC103481692 atr atr LOC103476762 LOC103476762 cul4b cul4b ube2a ube2a brca2 brca2 zbtb1 zbtb1 xpc xpc casp9 casp9 ino80 ino80 pold1 pold1 cdkn2d cdkn2d LOC103471497 LOC103471497 usf1 usf1 smpd1 smpd1 LOC103473809 LOC103473809 polh polh noc2l noc2l ube4b ube4b MFAP4 MFAP4 trim32 trim32 LOC103482089 LOC103482089 ercc4 ercc4 LOC103457850 LOC103457850 bivm bivm sprtn sprtn chek1 chek1 dcun1d3 dcun1d3 LOC103479463 LOC103479463 ercc8 ercc8 LOC103468460 LOC103468460 stk11 stk11 map2k7 map2k7 tp53inp1 tp53inp1 rhbdd1 rhbdd1 ercc2 ercc2 pold3 pold3 opn5 opn5 pclaf pclaf EIF2AK4 EIF2AK4 impact impact bmf bmf LOC103482005 LOC103482005 usp1 usp1 ercc6 ercc6 cul4a cul4a ercc5 ercc5 hmgn5 hmgn5 LOC103470988 LOC103470988 rhno1 rhno1 LOC103459783 LOC103459783 LOC103467285 LOC103467285 map3k4 map3k4 Cops9 Cops9 msh6 msh6 usp47 usp47
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
xpaXeroderma pigmentosum, complementation group A. (275 aa)
LOC103464091CREB binding protein a. (2371 aa)
Arhgap30Rho-GAP domain-containing protein. (63 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
ENSPREP00000001630RHD domain-containing protein. (238 aa)
Nfatc4Uncharacterized protein. (238 aa)
actr5Actin related protein 5; Belongs to the actin family. (624 aa)
LOC103462295Zgc:153993. (263 aa)
LOC103466877Mitogen-activated protein kinase. (364 aa)
LOC103464907Mitogen-activated protein kinase. (363 aa)
mc1rMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (314 aa)
sirt1Sirtuin 1. (677 aa)
opn3Opsin 3. (490 aa)
dhx36DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1057 aa)
LOC103461212Fibrinogen C-terminal domain-containing protein. (241 aa)
polkPolymerase (DNA directed) kappa. (880 aa)
men1Multiple endocrine neoplasia I. (627 aa)
bcl2BCL2 apoptosis regulator b. (230 aa)
ddb1Damage-specific DNA binding protein 1. (1102 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (855 aa)
msh2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (937 aa)
ube2bUbiquitin-conjugating enzyme E2B (RAD6 homolog); Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
primpolPrimase and polymerase (DNA-directed). (525 aa)
ENSPREP00000007854Uncharacterized protein. (143 aa)
ro60Ro60, Y RNA binding protein. (537 aa)
tp53i13Uncharacterized protein. (577 aa)
tmem161aTransmembrane protein 161A. (496 aa)
aqp1Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
ENSPREP00000010780Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (176 aa)
dtlDenticleless E3 ubiquitin protein ligase homolog (Drosophila). (704 aa)
IL12BInterleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (323 aa)
crebbpCREB binding protein b. (2452 aa)
ppidPeptidylprolyl isomerase D. (373 aa)
zranb3Zinc finger, RAN-binding domain containing 3. (1098 aa)
rev1REV1 DNA directed polymerase. (1360 aa)
eif2s1Eukaryotic translation initiation factor 2, subunit 1 alpha b. (310 aa)
BAXBCL2 associated X, apoptosis regulator. (191 aa)
ercc1Excision repair cross-complementation group 1. (358 aa)
LOC103480536Methyltransferase like 3; Belongs to the MT-A70-like family. (287 aa)
ddb2Damage-specific DNA binding protein 2. (490 aa)
LOC103481692Fibrinogen C-terminal domain-containing protein. (245 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2589 aa)
LOC103476762ALMS_motif domain-containing protein. (417 aa)
cul4bCullin 4B; Belongs to the cullin family. (872 aa)
ube2aUbiquitin-conjugating enzyme E2A (RAD6 homolog); Belongs to the ubiquitin-conjugating enzyme family. (207 aa)
brca2BRCA2 DNA repair associated. (3038 aa)
zbtb1Zinc finger and BTB domain containing 1. (681 aa)
xpcXeroderma pigmentosum, complementation group C. (852 aa)
casp9Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (427 aa)
ino80INO80 complex ATPase subunit. (1484 aa)
pold1DNA polymerase. (1102 aa)
cdkn2dCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
LOC103471497Aurora kinase B; Belongs to the protein kinase superfamily. (350 aa)
usf1Upstream transcription factor 1. (303 aa)
smpd1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (602 aa)
LOC103473809Fibrinogen C-terminal domain-containing protein. (239 aa)
polhPolymerase (DNA directed), eta. (716 aa)
noc2lNOC2-like nucleolar associated transcriptional repressor. (556 aa)
ube4bUbiquitination factor E4B, UFD2 homolog (S. cerevisiae). (1184 aa)
MFAP4Microfibril associated protein 4. (252 aa)
trim32Tripartite motif containing 32. (628 aa)
LOC103482089Fibrinogen C-terminal domain-containing protein. (244 aa)
ercc4Excision repair cross-complementation group 4. (893 aa)
LOC103457850Opsin 8, group member b; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (345 aa)
bivmBasic, immunoglobulin-like variable motif containing. (500 aa)
sprtnSprT-like N-terminal domain. (494 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (478 aa)
dcun1d3DCN1-like protein. (326 aa)
LOC103479463Sirtuin 6. (339 aa)
ercc8Excision repair cross-complementation group 8. (401 aa)
LOC103468460E1A binding protein p300 b. (2737 aa)
stk11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
map2k7Mitogen-activated protein kinase kinase 7. (418 aa)
tp53inp1Tumor protein p53 inducible nuclear protein 1. (298 aa)
rhbdd1Rhomboid domain containing 1. (312 aa)
ercc2Excision repair cross-complementation group 2. (655 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
opn5Opsin 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
pclafPCNA clamp associated factor. (115 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1652 aa)
impactImpact RWD domain protein. (320 aa)
bmfUncharacterized protein. (160 aa)
LOC103482005E1A binding protein p300 a. (2743 aa)
usp1Ubiquitin carboxyl-terminal hydrolase. (805 aa)
ercc6Excision repair cross-complementation group 6. (1402 aa)
cul4aCullin 4A; Belongs to the cullin family. (591 aa)
ercc5Excision repair cross-complementation group 5. (980 aa)
hmgn5High mobility group nucleosome binding domain 6. (81 aa)
LOC103470988UV-stimulated scaffold protein A. (688 aa)
rhno1Si:ch73-352p4.5. (221 aa)
LOC103459783Ubiquitin conjugating enzyme E2 A, like; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
LOC103467285Mitogen-activated protein kinase. (347 aa)
map3k4Mitogen-activated protein kinase kinase kinase 4. (1587 aa)
Cops9COP9 signalosome subunit 9. (78 aa)
msh6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1380 aa)
usp47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1357 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.