(18 nodes) Regulation of cell fate commitment network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103471993	T-box transcription factor Ta. (421 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	LOC103469672	Fibroblast growth factor receptor. (831 aa)
	LOC103473440	Notch receptor 1a. (2478 aa)
	notch1	Notch receptor 1b. (2491 aa)
	churc1	Churchill domain containing 1. (112 aa)
	LOC103473609	POU domain protein. (513 aa)
	tbx21	T-box transcription factor 21. (614 aa)
	vsx1	Uncharacterized protein. (275 aa)
	fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC103476799	Dickkopf WNT signaling pathway inhibitor 1a. (242 aa)
	bmp2	Bone morphogenetic protein 2b. (419 aa)
	ENSPREP00000025759	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
	LOC103474475	Uncharacterized protein. (342 aa)
	LOC103476521	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC103475709	Androgen receptor. (757 aa)
	sostdc1	Sclerostin domain containing 1a. (219 aa)
	ar	Androgen receptor. (685 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000025759	LOC103474475	ENSPREP00000025759	ENSPREP00000028750	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein.	0.817
ENSPREP00000025759	sfrp2	ENSPREP00000025759	ENSPREP00000000067	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Secreted frizzled-related protein 2.	0.817
LOC103469672	LOC103476521	ENSPREP00000001007	ENSPREP00000029747	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.933
LOC103469672	fgf17	ENSPREP00000001007	ENSPREP00000019823	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.828
LOC103471993	LOC103473609	ENSPREP00000021918	ENSPREP00000011597	T-box transcription factor Ta.	POU domain protein.	0.672
LOC103471993	LOC103476521	ENSPREP00000021918	ENSPREP00000029747	T-box transcription factor Ta.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.500
LOC103471993	bmp2	ENSPREP00000021918	ENSPREP00000023949	T-box transcription factor Ta.	Bone morphogenetic protein 2b.	0.419
LOC103473609	LOC103471993	ENSPREP00000011597	ENSPREP00000021918	POU domain protein.	T-box transcription factor Ta.	0.672
LOC103473609	tbx21	ENSPREP00000011597	ENSPREP00000019011	POU domain protein.	T-box transcription factor 21.	0.472
LOC103474475	ENSPREP00000025759	ENSPREP00000028750	ENSPREP00000025759	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.817
LOC103474475	LOC103476799	ENSPREP00000028750	ENSPREP00000021364	Uncharacterized protein.	Dickkopf WNT signaling pathway inhibitor 1a.	0.436
LOC103475709	ar	ENSPREP00000030777	ENSPREP00000031253	Androgen receptor.	Androgen receptor.	0.902
LOC103476521	LOC103469672	ENSPREP00000029747	ENSPREP00000001007	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.933
LOC103476521	LOC103471993	ENSPREP00000029747	ENSPREP00000021918	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	T-box transcription factor Ta.	0.500
LOC103476521	fgf17	ENSPREP00000029747	ENSPREP00000019823	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.439
LOC103476799	LOC103474475	ENSPREP00000021364	ENSPREP00000028750	Dickkopf WNT signaling pathway inhibitor 1a.	Uncharacterized protein.	0.436
LOC103476799	sfrp2	ENSPREP00000021364	ENSPREP00000000067	Dickkopf WNT signaling pathway inhibitor 1a.	Secreted frizzled-related protein 2.	0.436
ar	LOC103475709	ENSPREP00000031253	ENSPREP00000030777	Androgen receptor.	Androgen receptor.	0.902
bmp2	LOC103471993	ENSPREP00000023949	ENSPREP00000021918	Bone morphogenetic protein 2b.	T-box transcription factor Ta.	0.419
fgf17	LOC103469672	ENSPREP00000019823	ENSPREP00000001007	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.828