(15 nodes) Positive regulation of heart rate network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	edn1	Endothelin 1. (207 aa)
	LOC103470566	Adrenoceptor alpha 1Aa. (480 aa)
	LOC103481546	GTP cyclohydrolase 2. (236 aa)
	adra1b	Adrenoceptor alpha 1Bb. (509 aa)
	ENSPREP00000005770	Uncharacterized protein. (179 aa)
	kcnq1	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (631 aa)
	adm	Adrenomedullin a. (165 aa)
	scn3b	Sodium channel, voltage-gated, type III, beta. (216 aa)
	LOC103473975	Adrenoceptor alpha 1Ab. (465 aa)
	ENSPREP00000028578	Ion_trans domain-containing protein; Belongs to the potassium channel family. (424 aa)
	gch1	GTP cyclohydrolase 1. (255 aa)
	LOC103459727	Uncharacterized protein. (169 aa)
	LOC103476339	G_PROTEIN_RECEP_F1_2 domain-containing protein. (484 aa)
	LOC103471983	Endothelin 2. (172 aa)
	adra1d	Adrenoceptor alpha 1D. (514 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000005770	LOC103459727	ENSPREP00000005770	ENSPREP00000025491	Uncharacterized protein.	Uncharacterized protein.	0.741
LOC103459727	ENSPREP00000005770	ENSPREP00000025491	ENSPREP00000005770	Uncharacterized protein.	Uncharacterized protein.	0.741
LOC103459727	adm	ENSPREP00000025491	ENSPREP00000034108	Uncharacterized protein.	Adrenomedullin a.	0.546
LOC103470566	edn1	ENSPREP00000012668	ENSPREP00000012837	Adrenoceptor alpha 1Aa.	Endothelin 1.	0.551
LOC103471983	edn1	ENSPREP00000021381	ENSPREP00000012837	Endothelin 2.	Endothelin 1.	0.616
LOC103473975	edn1	ENSPREP00000032662	ENSPREP00000012837	Adrenoceptor alpha 1Ab.	Endothelin 1.	0.551
LOC103476339	edn1	ENSPREP00000024184	ENSPREP00000012837	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Endothelin 1.	0.509
LOC103481546	gch1	ENSPREP00000007486	ENSPREP00000027524	GTP cyclohydrolase 2.	GTP cyclohydrolase 1.	0.901
adm	LOC103459727	ENSPREP00000034108	ENSPREP00000025491	Adrenomedullin a.	Uncharacterized protein.	0.546
adra1b	edn1	ENSPREP00000006196	ENSPREP00000012837	Adrenoceptor alpha 1Bb.	Endothelin 1.	0.509
adra1d	edn1	ENSPREP00000013411	ENSPREP00000012837	Adrenoceptor alpha 1D.	Endothelin 1.	0.509
edn1	LOC103470566	ENSPREP00000012837	ENSPREP00000012668	Endothelin 1.	Adrenoceptor alpha 1Aa.	0.551
edn1	LOC103471983	ENSPREP00000012837	ENSPREP00000021381	Endothelin 1.	Endothelin 2.	0.616
edn1	LOC103473975	ENSPREP00000012837	ENSPREP00000032662	Endothelin 1.	Adrenoceptor alpha 1Ab.	0.551
edn1	LOC103476339	ENSPREP00000012837	ENSPREP00000024184	Endothelin 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.509
edn1	adra1b	ENSPREP00000012837	ENSPREP00000006196	Endothelin 1.	Adrenoceptor alpha 1Bb.	0.509
edn1	adra1d	ENSPREP00000012837	ENSPREP00000013411	Endothelin 1.	Adrenoceptor alpha 1D.	0.509
gch1	LOC103481546	ENSPREP00000027524	ENSPREP00000007486	GTP cyclohydrolase 1.	GTP cyclohydrolase 2.	0.901