(109 nodes) Striated muscle tissue development network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	SGCZ	Sarcoglycan zeta. (287 aa)
	bmp2	Bone morphogenetic protein 2b. (419 aa)
	zfpm2	Zinc finger protein, FOG family member 2a. (1168 aa)
	vwa5b2	Von Willebrand factor A domain containing 5B2. (1248 aa)
	LOC103480654	Uncharacterized protein. (311 aa)
	Cby1	Chibby homolog 1 (Drosophila). (189 aa)
	sav1	Salvador family WW domain containing protein 1. (383 aa)
	LOC103479463	Sirtuin 6. (339 aa)
	myocd	SAP domain-containing protein. (936 aa)
	map2k4	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily. (418 aa)
	alpk2	Uncharacterized protein. (1369 aa)
	LOC103475119	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	acadm	Acyl-CoA dehydrogenase medium chain. (422 aa)
	tbx1	T-box transcription factor 1. (498 aa)
	SMAD4	Mothers against decapentaplegic homolog. (439 aa)
	sgcb	Sarcoglycan, beta (dystrophin-associated glycoprotein). (311 aa)
	csrp3	Cysteine and glycine-rich protein 3 (cardiac LIM protein). (193 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	nkx2-5	NK2 homeobox 5. (316 aa)
	LOC103458509	C2H2-type domain-containing protein. (336 aa)
	nox4	FAD-binding FR-type domain-containing protein. (540 aa)
	tnni1	Troponin I type 1a (skeletal, slow). (205 aa)
	LOC103467401	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	LOC103476521	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	GREM1	Gremlin. (182 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (471 aa)
	tbx20	T-box transcription factor 20. (440 aa)
	LOC103466188	Uncharacterized protein. (283 aa)
	adprhl1	ADP-ribosylhydrolase like 1. (1017 aa)
	tsc1	TSC complex subunit 1b. (1243 aa)
	ptcd2	Pentatricopeptide repeat domain 2. (391 aa)
	hand2	Heart and neural crest derivatives expressed 2. (226 aa)
	sema3c	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Belongs to the semaphorin family. (746 aa)
	nrap	Nebulin-related anchoring protein. (1797 aa)
	LOC103474638	Bone morphogenetic protein 16. (512 aa)
	LOC103471340	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (440 aa)
	LOC103477474	Mothers against decapentaplegic homolog. (534 aa)
	ENSPREP00000022268	VIT domain-containing protein. (173 aa)
	arid2	AT rich interactive domain 2 (ARID, RFX-like). (1662 aa)
	kdm6b	Lysine (K)-specific demethylase 6B, a. (2105 aa)
	LOC103469565	T-box transcription factor 3b. (491 aa)
	tbx3	T-box transcription factor 3a. (708 aa)
	LOC103473796	T-box transcription factor 5a. (524 aa)
	LOC103457094	Uncharacterized protein. (238 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (212 aa)
	LOC103473773	Mothers against decapentaplegic homolog. (503 aa)
	LOC103479798	Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (189 aa)
	LOC103479803	Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (190 aa)
	LOC103457937	D4, zinc and double PHD fingers, family 3. (415 aa)
	sgcd	Sarcoglycan, delta (dystrophin-associated glycoprotein). (379 aa)
	ENSPREP00000019402	Protein kinase domain-containing protein. (201 aa)
	LOC103464710	Troponin I type 1b (skeletal, slow). (170 aa)
	Pln	Uncharacterized protein. (180 aa)
	LOC103457067	Ankyrin repeat and SOCS box containing 2a, tandem duplicate 1. (565 aa)
	LRRC10B	Leucine rich repeat containing 10B. (410 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1001 aa)
	ENSPREP00000016378	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (702 aa)
	tcap	Titin-cap (telethonin). (187 aa)
	LOC103473699	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	LOC103470605	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	myl7	Myosin, light chain 7, regulatory. (175 aa)
	ifrd1	Interferon-related developmental regulator 1. (428 aa)
	dipk2a	Divergent protein kinase domain 2Ab. (434 aa)
	LOC103460864	Uncharacterized protein; Belongs to the MAGUK family. (538 aa)
	ENSPREP00000013704	Uncharacterized protein. (155 aa)
	wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa)
	LOC103462735	Uncharacterized protein. (1048 aa)
	ENSPREP00000012944	Uncharacterized protein. (139 aa)
	ENSPREP00000012925	Uncharacterized protein. (113 aa)
	srf	Serum response factor b. (570 aa)
	mpp5	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (650 aa)
	LOC103465822	Troponin I4b, tandem duplicate 2. (178 aa)
	LOC103465821	Uncharacterized protein. (183 aa)
	LOC103465820	Troponin I4b, tandem duplicate 2. (182 aa)
	LOC103465819	Troponin I4a. (177 aa)
	TNNC1	Troponin C type 1a (slow). (163 aa)
	alpk3	Uncharacterized protein. (1797 aa)
	Nprl3	NPR3-like, GATOR1 complex subunit. (206 aa)
	ENSPREP00000011155	Uncharacterized protein. (74 aa)
	tbx10	Uncharacterized protein. (280 aa)
	LOC103472384	RNA binding motif protein 24a. (242 aa)
	ENSPREP00000010666	Uncharacterized protein. (64 aa)
	fermt2	Fermitin family member 2. (712 aa)
	bmp4	Bone morphogenetic protein 4. (480 aa)
	ENSPREP00000009398	Homeobox domain-containing protein. (161 aa)
	opa1	OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1031 aa)
	irx3	Iroquois homeobox 3a. (457 aa)
	mef2a	Myocyte enhancer factor 2aa. (535 aa)
	cemip2	Cell migration inducing hyaluronidase 2. (1389 aa)
	LOC103474795	Uncharacterized protein. (762 aa)
	SRF	Serum response factor. (243 aa)
	lrrc39	Leucine rich repeat containing 39. (378 aa)
	mef2c	Myocyte enhancer factor 2cb. (544 aa)
	LOC103476588	Uncharacterized protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. (336 aa)
	LOC103462206	MADS-box domain-containing protein. (467 aa)
	LOC103473526	Interferon-related developmental regulator 2. (455 aa)
	sgcg	Sarcoglycan, gamma. (306 aa)
	unc45b	Unc-45 myosin chaperone B. (929 aa)
	LOC103482193	Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (506 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (372 aa)
	neb	Nebulin. (6138 aa)
	LOC103468062	Troponin C type 1b (slow). (161 aa)
	taz	Tafazzin family protein; Belongs to the taffazin family. (187 aa)
	LOC103475867	Lysine (K)-specific demethylase 6B, b. (1729 aa)
	mstn	Myostatin b. (376 aa)
	gja5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (376 aa)
	LOC103469672	Fibroblast growth factor receptor. (831 aa)
	LOC103478593	RNA binding motif protein 24b. (238 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000010666	ENSPREP00000016378	ENSPREP00000010666	ENSPREP00000016378	Uncharacterized protein.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.557
ENSPREP00000010666	Mtor	ENSPREP00000010666	ENSPREP00000016474	Uncharacterized protein.	Serine/threonine-protein kinase TOR.	0.557
ENSPREP00000011155	ENSPREP00000016378	ENSPREP00000011155	ENSPREP00000016378	Uncharacterized protein.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.557
ENSPREP00000011155	Mtor	ENSPREP00000011155	ENSPREP00000016474	Uncharacterized protein.	Serine/threonine-protein kinase TOR.	0.557
ENSPREP00000012925	ENSPREP00000012944	ENSPREP00000012925	ENSPREP00000012944	Uncharacterized protein.	Uncharacterized protein.	0.746
ENSPREP00000012944	ENSPREP00000012925	ENSPREP00000012944	ENSPREP00000012925	Uncharacterized protein.	Uncharacterized protein.	0.746
ENSPREP00000013704	LOC103460864	ENSPREP00000013704	ENSPREP00000013760	Uncharacterized protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.854
ENSPREP00000016378	ENSPREP00000010666	ENSPREP00000016378	ENSPREP00000010666	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.557
ENSPREP00000016378	ENSPREP00000011155	ENSPREP00000016378	ENSPREP00000011155	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.557
ENSPREP00000016378	Mtor	ENSPREP00000016378	ENSPREP00000016474	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.934
ENSPREP00000016378	Nprl3	ENSPREP00000016378	ENSPREP00000011200	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	NPR3-like, GATOR1 complex subunit.	0.557
ENSPREP00000016378	atg5	ENSPREP00000016378	ENSPREP00000028618	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.456
ENSPREP00000016378	tsc1	ENSPREP00000016378	ENSPREP00000032075	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	TSC complex subunit 1b.	0.882
ENSPREP00000019402	map2k4	ENSPREP00000019402	ENSPREP00000026466	Protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily.	0.901
ENSPREP00000019402	myocd	ENSPREP00000019402	ENSPREP00000026384	Protein kinase domain-containing protein.	SAP domain-containing protein.	0.558
GREM1	LOC103474638	ENSPREP00000029815	ENSPREP00000033881	Gremlin.	Bone morphogenetic protein 16.	0.709
GREM1	bmp2	ENSPREP00000029815	ENSPREP00000023949	Gremlin.	Bone morphogenetic protein 2b.	0.709
GREM1	bmp4	ENSPREP00000029815	ENSPREP00000010205	Gremlin.	Bone morphogenetic protein 4.	0.709
HAND1	nkx2-5	ENSPREP00000020806	ENSPREP00000028859	Heart and neural crest derivatives expressed 1.	NK2 homeobox 5.	0.471
LOC103457937	arid2	ENSPREP00000019889	ENSPREP00000022141	D4, zinc and double PHD fingers, family 3.	AT rich interactive domain 2 (ARID, RFX-like).	0.586