(43 nodes) Positive regulation of macroautophagy network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tsc2	TSC complex subunit 2. (1898 aa)
	htt	Huntingtin. (3167 aa)
	Scoc	Short coiled-coil protein. (72 aa)
	LOC103459210	Decorin; May affect the rate of fibrils formation. (360 aa)
	LOC103463814	Short coiled-coil protein a. (79 aa)
	vps13d	Vacuolar protein sorting 13 homolog D. (3861 aa)
	c9orf72	Zgc:100846. (298 aa)
	LOC103473458	Zgc:73226. (215 aa)
	bag3	BCL2 associated athanogene 3. (516 aa)
	sirt1	Sirtuin 1. (677 aa)
	epm2a	EPM2A glucan phosphatase, laforin. (196 aa)
	PIP4K2B	Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (414 aa)
	rab3gap2	RAB3 GTPase activating protein subunit 2 (non-catalytic). (1373 aa)
	sting1	Transmembrane protein 173. (484 aa)
	sptlc1	Serine palmitoyltransferase, long chain base subunit 1. (479 aa)
	hspb8	Heat shock protein b8; Belongs to the small heat shock protein (HSP20) family. (221 aa)
	sesn1	Sestrin 1. (492 aa)
	LOC103472311	Sestrin 2. (558 aa)
	snx30	Sorting nexin family member 30. (443 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (582 aa)
	nod2	Nucleotide-binding oligomerization domain containing 2. (996 aa)
	LOC103460775	Si:dkey-181m9.8. (732 aa)
	LOC103471661	Si:zfos-80g12.1. (444 aa)
	nod1	Nucleotide-binding oligomerization domain containing 1. (884 aa)
	fyco1	FYVE and coiled-coil domain containing 1a. (1497 aa)
	LOC103461636	Sorting nexin 4. (455 aa)
	ENSPREP00000018072	Uncharacterized protein. (672 aa)
	bnip3	BCL2 interacting protein 3. (178 aa)
	Calcoco2	SKICH domain-containing protein. (143 aa)
	snx7	Sorting nexin 7. (463 aa)
	wdr45	WD repeat domain 45. (358 aa)
	pip4k2a	Phosphatidylinositol-5-phosphate 4-kinase, type II, alpha a. (443 aa)
	LOC103479840	FYVE and coiled-coil domain containing 1b. (1464 aa)
	gpsm1	G protein signaling modulator 1b. (662 aa)
	LOC103459747	PX domain-containing protein. (433 aa)
	wdr24	WD repeat domain 24. (776 aa)
	ENSPREP00000026918	Uncharacterized protein. (130 aa)
	ENSPREP00000028065	Forkhead box A3. (426 aa)
	ambra1	Autophagy/beclin-1 regulator 1b. (1210 aa)
	LOC103457268	Si:ch211-108d22.2. (2793 aa)
	tsc1	TSC complex subunit 1b. (1243 aa)
	pink1	PTEN induced kinase 1. (575 aa)
	rnf31	Ring finger protein 31. (1109 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Calcoco2	pink1	ENSPREP00000019405	ENSPREP00000032869	SKICH domain-containing protein.	PTEN induced kinase 1.	0.549
ENSPREP00000018072	ripk2	ENSPREP00000018072	ENSPREP00000009886	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 2.	0.808
LOC103457268	ripk2	ENSPREP00000031855	ENSPREP00000009886	Si:ch211-108d22.2.	Receptor-interacting serine-threonine kinase 2.	0.808
LOC103459747	LOC103461636	ENSPREP00000026485	ENSPREP00000016066	PX domain-containing protein.	Sorting nexin 4.	0.901
LOC103459747	snx30	ENSPREP00000026485	ENSPREP00000008011	PX domain-containing protein.	Sorting nexin family member 30.	0.852
LOC103459747	snx7	ENSPREP00000026485	ENSPREP00000019923	PX domain-containing protein.	Sorting nexin 7.	0.855
LOC103460775	ripk2	ENSPREP00000010849	ENSPREP00000009886	Si:dkey-181m9.8.	Receptor-interacting serine-threonine kinase 2.	0.932
LOC103460775	rnf31	ENSPREP00000010849	ENSPREP00000033338	Si:dkey-181m9.8.	Ring finger protein 31.	0.905
LOC103461636	LOC103459747	ENSPREP00000016066	ENSPREP00000026485	Sorting nexin 4.	PX domain-containing protein.	0.901
LOC103461636	snx30	ENSPREP00000016066	ENSPREP00000008011	Sorting nexin 4.	Sorting nexin family member 30.	0.853
LOC103461636	snx7	ENSPREP00000016066	ENSPREP00000019923	Sorting nexin 4.	Sorting nexin 7.	0.854
LOC103471661	LOC103472311	ENSPREP00000012834	ENSPREP00000007336	Si:zfos-80g12.1.	Sestrin 2.	0.905
LOC103471661	wdr24	ENSPREP00000012834	ENSPREP00000026593	Si:zfos-80g12.1.	WD repeat domain 24.	0.748
LOC103472311	LOC103471661	ENSPREP00000007336	ENSPREP00000012834	Sestrin 2.	Si:zfos-80g12.1.	0.905
LOC103472311	wdr24	ENSPREP00000007336	ENSPREP00000026593	Sestrin 2.	WD repeat domain 24.	0.976
LOC103473458	bnip3	ENSPREP00000003690	ENSPREP00000018111	Zgc:73226.	BCL2 interacting protein 3.	0.905
LOC103473458	pink1	ENSPREP00000003690	ENSPREP00000032869	Zgc:73226.	PTEN induced kinase 1.	0.454
LOC103479840	fyco1	ENSPREP00000024332	ENSPREP00000015970	FYVE and coiled-coil domain containing 1b.	FYVE and coiled-coil domain containing 1a.	0.903
bag3	hspb8	ENSPREP00000003708	ENSPREP00000006583	BCL2 associated athanogene 3.	Heat shock protein b8; Belongs to the small heat shock protein (HSP20) family.	0.908
bag3	ripk2	ENSPREP00000003708	ENSPREP00000009886	BCL2 associated athanogene 3.	Receptor-interacting serine-threonine kinase 2.	0.429