(30 nodes) Post-transcriptional gene silencing network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LIMD1	LIM domains containing 1. (540 aa)
	helz	Helicase with zinc finger. (2006 aa)
	MARF1	Meiosis regulator and mRNA stability factor 1. (1791 aa)
	LOC103469285	Trinucleotide repeat containing adaptor 6C1. (1769 aa)
	LOC103472230	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (894 aa)
	EIF4ENIF1	Eukaryotic translation initiation factor 4E nuclear import factor 1. (953 aa)
	LOC103475990	Ajuba LIM protein. (658 aa)
	LOC103463278	ELAV-like protein; Belongs to the RRM elav family. (360 aa)
	LOC103477773	Argonaute RISC component 1; Belongs to the argonaute family. (858 aa)
	LOC103477771	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (867 aa)
	ENSPREP00000013186	Uncharacterized protein. (199 aa)
	nrde2	NRDE-2, necessary for RNA interference, domain containing. (1204 aa)
	LOC103473053	Uncharacterized protein; Belongs to the argonaute family. (695 aa)
	zar1l	Zygote arrest 1-like. (337 aa)
	mov10l1	Uncharacterized protein. (1139 aa)
	ago4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (913 aa)
	LOC103464680	Mov10 RISC complex RNA helicase a. (992 aa)
	dicer1	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily. (1860 aa)
	LOC103468018	Trinucleotide repeat containing adaptor 6C2. (1547 aa)
	ddx6	DEAD (Asp-Glu-Ala-Asp) box helicase 6; Belongs to the DEAD box helicase family. (482 aa)
	disp2	Dispatched homolog 2 (Drosophila). (1421 aa)
	LOC103481147	TNRC6-PABC_bdg domain-containing protein. (1685 aa)
	tnrc6b	Si:dkey-46g23.1. (2000 aa)
	trim71	Tripartite motif containing 71, E3 ubiquitin protein ligase. (831 aa)
	xpo5	Exportin 5. (1172 aa)
	zar1	Zygote arrest 1. (330 aa)
	dhx9	DEAH (Asp-Glu-Ala-His) box helicase 9. (1216 aa)
	tnrc6a	Trinucleotide repeat containing adaptor 6A. (1659 aa)
	mov10	Moloney leukemia virus 10b, tandem duplicate 1. (1011 aa)
	LOC103458435	ELAV-like protein; Belongs to the RRM elav family. (348 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF4ENIF1	ENSPREP00000013186	ENSPREP00000003290	ENSPREP00000013186	Eukaryotic translation initiation factor 4E nuclear import factor 1.	Uncharacterized protein.	0.945
EIF4ENIF1	ddx6	ENSPREP00000003290	ENSPREP00000023831	Eukaryotic translation initiation factor 4E nuclear import factor 1.	DEAD (Asp-Glu-Ala-Asp) box helicase 6; Belongs to the DEAD box helicase family.	0.945
ENSPREP00000013186	EIF4ENIF1	ENSPREP00000013186	ENSPREP00000003290	Uncharacterized protein.	Eukaryotic translation initiation factor 4E nuclear import factor 1.	0.945
ENSPREP00000013186	LOC103468018	ENSPREP00000013186	ENSPREP00000023581	Uncharacterized protein.	Trinucleotide repeat containing adaptor 6C2.	0.440
ENSPREP00000013186	LOC103469285	ENSPREP00000013186	ENSPREP00000002233	Uncharacterized protein.	Trinucleotide repeat containing adaptor 6C1.	0.440
ENSPREP00000013186	LOC103472230	ENSPREP00000013186	ENSPREP00000002849	Uncharacterized protein.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.475
ENSPREP00000013186	LOC103473053	ENSPREP00000013186	ENSPREP00000013374	Uncharacterized protein.	Uncharacterized protein; Belongs to the argonaute family.	0.475
ENSPREP00000013186	LOC103477771	ENSPREP00000013186	ENSPREP00000009729	Uncharacterized protein.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily.	0.475
ENSPREP00000013186	LOC103477773	ENSPREP00000013186	ENSPREP00000009674	Uncharacterized protein.	Argonaute RISC component 1; Belongs to the argonaute family.	0.475
ENSPREP00000013186	LOC103481147	ENSPREP00000013186	ENSPREP00000025322	Uncharacterized protein.	TNRC6-PABC_bdg domain-containing protein.	0.550
ENSPREP00000013186	ago4	ENSPREP00000013186	ENSPREP00000015301	Uncharacterized protein.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily.	0.475
ENSPREP00000013186	ddx6	ENSPREP00000013186	ENSPREP00000023831	Uncharacterized protein.	DEAD (Asp-Glu-Ala-Asp) box helicase 6; Belongs to the DEAD box helicase family.	0.902
ENSPREP00000013186	dhx9	ENSPREP00000013186	ENSPREP00000028546	Uncharacterized protein.	DEAH (Asp-Glu-Ala-His) box helicase 9.	0.546
ENSPREP00000013186	dicer1	ENSPREP00000013186	ENSPREP00000017960	Uncharacterized protein.	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily.	0.499
ENSPREP00000013186	tnrc6a	ENSPREP00000013186	ENSPREP00000028671	Uncharacterized protein.	Trinucleotide repeat containing adaptor 6A.	0.440
LIMD1	LOC103475990	ENSPREP00000013791	ENSPREP00000007007	LIM domains containing 1.	Ajuba LIM protein.	0.532
LOC103458435	dhx9	ENSPREP00000016350	ENSPREP00000028546	ELAV-like protein; Belongs to the RRM elav family.	DEAH (Asp-Glu-Ala-His) box helicase 9.	0.564
LOC103463278	dhx9	ENSPREP00000008615	ENSPREP00000028546	ELAV-like protein; Belongs to the RRM elav family.	DEAH (Asp-Glu-Ala-His) box helicase 9.	0.564
LOC103468018	ENSPREP00000013186	ENSPREP00000023581	ENSPREP00000013186	Trinucleotide repeat containing adaptor 6C2.	Uncharacterized protein.	0.440
LOC103468018	LOC103472230	ENSPREP00000023581	ENSPREP00000002849	Trinucleotide repeat containing adaptor 6C2.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.744