(76 nodes) Nuclear receptor binding network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ncoa1	Nuclear receptor coactivator 1. (1196 aa)
	ENSPREP00000025676	Coiled-coil domain containing 62. (364 aa)
	taf10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (186 aa)
	DCAF1	DDB1 and CUL4 associated factor 1. (1356 aa)
	LOC103467517	Glutamate receptor interacting protein 2a. (1064 aa)
	LOC103478059	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
	nr4a2	Nuclear receptor subfamily 4, group A, member 2b. (601 aa)
	nr0b2	Nuclear receptor subfamily 0, group B, member 2a. (260 aa)
	LOC103467002	Nuclear receptor subfamily 1, group H, member 5. (494 aa)
	prmt2	Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (379 aa)
	nrip1	Nuclear receptor interacting protein 1b. (1200 aa)
	med25	Mediator complex subunit 25. (748 aa)
	taf7l	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (383 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (591 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (550 aa)
	ddx54	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (855 aa)
	LOC103464804	LisH domain-containing protein. (1582 aa)
	znf366	Zinc finger protein 366. (757 aa)
	bcas3	BCAS3 microtubule associated cell migration factor. (666 aa)
	LOC103473768	Uncharacterized protein. (614 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
	LOC103462977	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
	LOC103467778	Nuclear receptor subfamily 4, group A, member 1. (562 aa)
	LOC103464964	Transforming, acidic coiled-coil containing protein 1. (927 aa)
	ncor2	Nuclear receptor corepressor 2. (2291 aa)
	LOC103470370	TACC_C domain-containing protein. (503 aa)
	lef1	Lymphoid enhancer-binding factor 1. (422 aa)
	sirt1	Sirtuin 1. (677 aa)
	nrbf2	Nuclear receptor binding factor 2b. (270 aa)
	LOC103477205	TACC_C domain-containing protein. (3266 aa)
	SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (426 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (464 aa)
	LOC103471057	Bromodomain containing 8. (603 aa)
	ENSPREP00000006402	Uncharacterized protein. (79 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (855 aa)
	hmga1	Uncharacterized protein. (95 aa)
	rnf14	RBR-type E3 ubiquitin transferase. (452 aa)
	grip1	Glutamate receptor interacting protein 1. (1133 aa)
	LOC103460020	Nuclear receptor binding SET domain protein 1b. (1315 aa)
	LOC103471190	Nuclear receptor binding SET domain protein 1a. (2016 aa)
	dcaf13	Ddb1 and cul4 associated factor 13. (445 aa)
	LOC103470500	NK3 homeobox 1. (196 aa)
	LOC103469320	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (608 aa)
	ncor1	Nuclear receptor corepressor 1. (2343 aa)
	trip4	Thyroid hormone receptor interactor 4. (573 aa)
	NCOA3	Nuclear receptor coactivator. (1429 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (307 aa)
	gtf2b	General transcription factor IIB. (318 aa)
	LOC103470539	AT rich interactive domain 5A (MRF1-like). (589 aa)
	ppargc1b	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta. (929 aa)
	ENSPREP00000011356	Uncharacterized protein. (71 aa)
	ENSPREP00000011375	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (344 aa)
	ppid	Peptidylprolyl isomerase D. (373 aa)
	pagr1	PAXIP1 associated glutamate-rich protein 1. (277 aa)
	LOC103465576	Nuclear receptor coactivator 3. (1523 aa)
	LOC103457879	Uncharacterized protein. (801 aa)
	mms19	MMS19 homolog, cytosolic iron-sulfur assembly component. (1015 aa)
	LOC103482005	E1A binding protein p300 a. (2743 aa)
	LOC103480795	Uncharacterized protein. (996 aa)
	dnaaf4	Dynein axonemal assembly factor 4. (407 aa)
	ENSPREP00000028591	Uncharacterized protein. (79 aa)
	rnf6	Ring finger protein (C3H2C3 type) 6. (589 aa)
	Brd8	Si:ch211-59d17.3. (522 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (683 aa)
	ppargc1a	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (1284 aa)
	ENSPREP00000027951	Uncharacterized protein. (379 aa)
	cnot1	CCR4-NOT transcription complex, subunit 1. (2246 aa)
	nr4a3	Nuclear receptor subfamily 4, group A, member 3. (587 aa)
	LOC103467472	Nuclear receptor coactivator 6. (2360 aa)
	snw1	SNW domain containing 1. (536 aa)
	ncoa2	Nuclear receptor coactivator 2. (1521 aa)
	bud31	BUD31 homolog. (103 aa)
	tmf1	TATA element modulatory factor 1. (1150 aa)
	prpf6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae). (1016 aa)
	LOC103468460	E1A binding protein p300 b. (2737 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (485 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brd8	ENSPREP00000006402	ENSPREP00000028553	ENSPREP00000006402	Si:ch211-59d17.3.	Uncharacterized protein.	0.933
Brd8	ENSPREP00000028591	ENSPREP00000028553	ENSPREP00000028591	Si:ch211-59d17.3.	Uncharacterized protein.	0.933
ENSPREP00000006402	Brd8	ENSPREP00000006402	ENSPREP00000028553	Uncharacterized protein.	Si:ch211-59d17.3.	0.933
ENSPREP00000006402	LOC103471057	ENSPREP00000006402	ENSPREP00000006352	Uncharacterized protein.	Bromodomain containing 8.	0.932
ENSPREP00000027951	LOC103467002	ENSPREP00000027951	ENSPREP00000014015	Uncharacterized protein.	Nuclear receptor subfamily 1, group H, member 5.	0.748
ENSPREP00000027951	LOC103467472	ENSPREP00000027951	ENSPREP00000027241	Uncharacterized protein.	Nuclear receptor coactivator 6.	0.496
ENSPREP00000027951	LOC103468460	ENSPREP00000027951	ENSPREP00000026558	Uncharacterized protein.	E1A binding protein p300 b.	0.654
ENSPREP00000027951	LOC103482005	ENSPREP00000027951	ENSPREP00000030842	Uncharacterized protein.	E1A binding protein p300 a.	0.654
ENSPREP00000027951	ncoa1	ENSPREP00000027951	ENSPREP00000026131	Uncharacterized protein.	Nuclear receptor coactivator 1.	0.510
ENSPREP00000027951	ncor1	ENSPREP00000027951	ENSPREP00000009626	Uncharacterized protein.	Nuclear receptor corepressor 1.	0.496
ENSPREP00000027951	ncor2	ENSPREP00000027951	ENSPREP00000001887	Uncharacterized protein.	Nuclear receptor corepressor 2.	0.496
ENSPREP00000027951	nr1h3	ENSPREP00000027951	ENSPREP00000006124	Uncharacterized protein.	Nuclear receptor subfamily 1, group H, member 3.	0.849
ENSPREP00000027951	nr1h4	ENSPREP00000027951	ENSPREP00000026448	Uncharacterized protein.	Nuclear receptor subfamily 1, group H, member 4.	0.748
ENSPREP00000028591	Brd8	ENSPREP00000028591	ENSPREP00000028553	Uncharacterized protein.	Si:ch211-59d17.3.	0.933
ENSPREP00000028591	LOC103471057	ENSPREP00000028591	ENSPREP00000006352	Uncharacterized protein.	Bromodomain containing 8.	0.933
LOC103462977	PRKCA	ENSPREP00000000513	ENSPREP00000000304	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.901
LOC103462977	PRKCB	ENSPREP00000000513	ENSPREP00000028542	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.900
LOC103464964	LOC103477205	ENSPREP00000001050	ENSPREP00000005215	Transforming, acidic coiled-coil containing protein 1.	TACC_C domain-containing protein.	0.550
LOC103465576	LOC103467002	ENSPREP00000033085	ENSPREP00000014015	Nuclear receptor coactivator 3.	Nuclear receptor subfamily 1, group H, member 5.	0.748
LOC103465576	LOC103467472	ENSPREP00000033085	ENSPREP00000027241	Nuclear receptor coactivator 3.	Nuclear receptor coactivator 6.	0.496