(34 nodes) Wnt-protein binding network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103479948	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	fzd10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	porcn	Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (425 aa)
	ENSPREP00000005844	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	Fzd8	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (556 aa)
	lrp5	Low density lipoprotein receptor-related protein 5. (1649 aa)
	TRABD2A	TraB domain containing 2A. (520 aa)
	wls	Wnt ligand secretion mediator. (448 aa)
	LOC103466972	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (481 aa)
	LOC103465844	Sizzled. (338 aa)
	APCDD1	APC down-regulated 1. (503 aa)
	ENSPREP00000015698	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
	LOC103464668	Adenomatosis polyposis coli down-regulated 1-like. (532 aa)
	LOC103463566	TraB domain containing 2B. (535 aa)
	LOC103462771	Frizzled class receptor 3b; Belongs to the G-protein coupled receptor Fz/Smo family. (776 aa)
	LOC103460948	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (573 aa)
	sfrp1	Secreted frizzled-related protein 1a. (305 aa)
	ryk	Receptor like tyrosine kinase. (632 aa)
	fzd6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (710 aa)
	cthrc1	Collagen triple helix repeat containing 1b. (230 aa)
	fzd9	Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	LOC103477605	Uncharacterized protein. (646 aa)
	ENSPREP00000027507	FZ domain-containing protein. (87 aa)
	Lrp6	LDL receptor related protein 6. (628 aa)
	ENSPREP00000027584	Low density lipoprotein receptor-related protein 6. (914 aa)
	LOC103467455	Uncharacterized protein. (275 aa)
	fzd3	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family. (735 aa)
	fjx1	Four-jointed box kinase 1. (427 aa)
	sfrp5	Secreted frizzled-related protein 5. (323 aa)
	LOC103474475	Uncharacterized protein. (342 aa)
	ror1	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (953 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
	frzb	Frizzled related protein. (331 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000005844	ENSPREP00000027584	ENSPREP00000005844	ENSPREP00000027584	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Low density lipoprotein receptor-related protein 6.	0.536
ENSPREP00000005844	LOC103474475	ENSPREP00000005844	ENSPREP00000028750	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.673
ENSPREP00000005844	Lrp6	ENSPREP00000005844	ENSPREP00000027540	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	LDL receptor related protein 6.	0.903
ENSPREP00000005844	fzd4	ENSPREP00000005844	ENSPREP00000030507	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.426
ENSPREP00000005844	lrp5	ENSPREP00000005844	ENSPREP00000009756	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Low density lipoprotein receptor-related protein 5.	0.903
ENSPREP00000005844	ror1	ENSPREP00000005844	ENSPREP00000030444	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.952
ENSPREP00000005844	ryk	ENSPREP00000005844	ENSPREP00000022759	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor like tyrosine kinase.	0.927
ENSPREP00000005844	sfrp1	ENSPREP00000005844	ENSPREP00000022052	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 1a.	0.674
ENSPREP00000005844	sfrp2	ENSPREP00000005844	ENSPREP00000000067	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 2.	0.673
ENSPREP00000005844	sfrp5	ENSPREP00000005844	ENSPREP00000028596	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 5.	0.668
ENSPREP00000015698	ENSPREP00000027584	ENSPREP00000015698	ENSPREP00000027584	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Low density lipoprotein receptor-related protein 6.	0.514
ENSPREP00000015698	LOC103474475	ENSPREP00000015698	ENSPREP00000028750	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.687
ENSPREP00000015698	Lrp6	ENSPREP00000015698	ENSPREP00000027540	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	LDL receptor related protein 6.	0.898
ENSPREP00000015698	fzd4	ENSPREP00000015698	ENSPREP00000030507	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.432
ENSPREP00000015698	lrp5	ENSPREP00000015698	ENSPREP00000009756	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Low density lipoprotein receptor-related protein 5.	0.898
ENSPREP00000015698	ror1	ENSPREP00000015698	ENSPREP00000030444	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.953
ENSPREP00000015698	ryk	ENSPREP00000015698	ENSPREP00000022759	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor like tyrosine kinase.	0.929
ENSPREP00000015698	sfrp1	ENSPREP00000015698	ENSPREP00000022052	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 1a.	0.688
ENSPREP00000015698	sfrp2	ENSPREP00000015698	ENSPREP00000000067	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 2.	0.687
ENSPREP00000015698	sfrp5	ENSPREP00000015698	ENSPREP00000028596	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 5.	0.688