(63 nodes) SCF ubiquitin ligase complex network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103461978	F-box domain-containing protein. (451 aa)
	fbxl18	F-box and leucine-rich repeat protein 18. (719 aa)
	LRRC29	Leucine rich repeat containing 29. (195 aa)
	fbxo25	F-box protein 25. (365 aa)
	fbxl15	F-box and leucine-rich repeat protein 15. (294 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1357 aa)
	fbxw11	F-box and WD repeat domain containing 11a. (562 aa)
	fbxl7	Si:dkey-192l18.9. (493 aa)
	cacybp	Calcyclin binding protein. (234 aa)
	tmem183a	Transmembrane protein 183A. (360 aa)
	LOC103467680	Uncharacterized protein. (269 aa)
	LOC103467948	Uncharacterized protein. (254 aa)
	LOC103467682	Uncharacterized protein. (292 aa)
	LOC103467679	Uncharacterized protein. (280 aa)
	FBXL14	F-box and leucine rich repeat protein 14. (400 aa)
	fbxo48	F-box protein 48. (153 aa)
	fbxo33	F-box protein 33. (490 aa)
	skp1	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (107 aa)
	LOC103459322	F-box domain-containing protein. (429 aa)
	fbxo42	F-box protein 42. (701 aa)
	fbxw8	F-box and WD repeat domain containing 8. (655 aa)
	fbxl2	F-box and leucine-rich repeat protein 2. (432 aa)
	skp2	F-box domain-containing protein. (426 aa)
	cul2	Cullin 2; Belongs to the cullin family. (745 aa)
	fbxo7	F-box protein 7. (465 aa)
	fbxl3	F-box and leucine-rich repeat protein 3a. (435 aa)
	dmac2	Si:ch1073-228b5.2. (271 aa)
	fbxl22	F-box and leucine-rich repeat protein 22. (228 aa)
	fbxo45	F-box protein 45. (289 aa)
	cul1	Cullin 1b; Belongs to the cullin family. (776 aa)
	fbxo9	F-box protein 9. (421 aa)
	spsb4	SplA/ryanodine receptor domain and SOCS box containing 4a. (278 aa)
	fbxl20	F-box and leucine-rich repeat protein 20. (436 aa)
	nccrp1	Non-specific cytotoxic cell receptor protein 1. (257 aa)
	fbxl16	F-box and leucine-rich repeat protein 16. (505 aa)
	LOC103463560	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (76 aa)
	fbxl19	Uncharacterized protein. (558 aa)
	fbxo32	F-box protein 32. (352 aa)
	fbxo15	F-box domain-containing protein. (452 aa)
	LOC103479318	SplA/ryanodine receptor domain and SOCS box containing 4a. (286 aa)
	fbxl6	F-box domain-containing protein. (555 aa)
	fbxw5	F-box and WD repeat domain containing 5. (626 aa)
	spsb1	SplA/ryanodine receptor domain and SOCS box containing 1. (273 aa)
	spsb3	SplA/ryanodine receptor domain and SOCS box containing 3a. (371 aa)
	LOC103461142	F-box and WD repeat domain containing 4. (264 aa)
	fbxo39	Uncharacterized protein. (377 aa)
	fbxl14	F-box and leucine-rich repeat protein 14a. (403 aa)
	fbxl4	F-box and leucine-rich repeat protein 4. (613 aa)
	Fbxl17	F-box domain-containing protein. (354 aa)
	ENSPREP00000023888	Uncharacterized protein. (220 aa)
	fbxl13	F-box and leucine-rich repeat protein 13. (799 aa)
	fbxo4	F-box protein 4. (361 aa)
	CKS2	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (76 aa)
	ENSPREP00000026167	F-box DNA helicase 1. (875 aa)
	daw1	WD_REPEATS_REGION domain-containing protein. (415 aa)
	LOC103478677	Si:ch1073-228j22.2. (284 aa)
	rbx1	Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
	LOC103465417	Zgc:175088. (191 aa)
	fbxo31	F-box protein 31. (585 aa)
	fbxl5	F-box and leucine-rich repeat protein 5. (697 aa)
	LOC103481104	SplA/ryanodine receptor domain and SOCS box containing 3b. (350 aa)
	cks1b	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (78 aa)
	ENSPREP00000029734	Uncharacterized protein. (99 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CKS2	cul1	ENSPREP00000025374	ENSPREP00000016001	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Cullin 1b; Belongs to the cullin family.	0.827
CKS2	rbx1	ENSPREP00000025374	ENSPREP00000026459	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Ring-box 1, E3 ubiquitin protein ligase.	0.462
CKS2	skp1	ENSPREP00000025374	ENSPREP00000007574	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.897
CKS2	skp2	ENSPREP00000025374	ENSPREP00000008789	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	F-box domain-containing protein.	0.937
ENSPREP00000023888	Fbxl17	ENSPREP00000023888	ENSPREP00000023856	Uncharacterized protein.	F-box domain-containing protein.	0.900
ENSPREP00000023888	cul1	ENSPREP00000023888	ENSPREP00000016001	Uncharacterized protein.	Cullin 1b; Belongs to the cullin family.	0.958
ENSPREP00000023888	rbx1	ENSPREP00000023888	ENSPREP00000026459	Uncharacterized protein.	Ring-box 1, E3 ubiquitin protein ligase.	0.781
ENSPREP00000023888	skp1	ENSPREP00000023888	ENSPREP00000007574	Uncharacterized protein.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.951
ENSPREP00000023888	skp2	ENSPREP00000023888	ENSPREP00000008789	Uncharacterized protein.	F-box domain-containing protein.	0.571
ENSPREP00000026167	cul1	ENSPREP00000026167	ENSPREP00000016001	F-box DNA helicase 1.	Cullin 1b; Belongs to the cullin family.	0.803
ENSPREP00000026167	rbx1	ENSPREP00000026167	ENSPREP00000026459	F-box DNA helicase 1.	Ring-box 1, E3 ubiquitin protein ligase.	0.664
ENSPREP00000026167	skp1	ENSPREP00000026167	ENSPREP00000007574	F-box DNA helicase 1.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.985
ENSPREP00000029734	LOC103461142	ENSPREP00000029734	ENSPREP00000022584	Uncharacterized protein.	F-box and WD repeat domain containing 4.	0.921
ENSPREP00000029734	cul1	ENSPREP00000029734	ENSPREP00000016001	Uncharacterized protein.	Cullin 1b; Belongs to the cullin family.	0.750
ENSPREP00000029734	fbxw5	ENSPREP00000029734	ENSPREP00000022269	Uncharacterized protein.	F-box and WD repeat domain containing 5.	0.485
ENSPREP00000029734	rbx1	ENSPREP00000029734	ENSPREP00000026459	Uncharacterized protein.	Ring-box 1, E3 ubiquitin protein ligase.	0.461
ENSPREP00000029734	skp1	ENSPREP00000029734	ENSPREP00000007574	Uncharacterized protein.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.745
FBXL14	cul1	ENSPREP00000006826	ENSPREP00000016001	F-box and leucine rich repeat protein 14.	Cullin 1b; Belongs to the cullin family.	0.758
FBXL14	fbxl18	ENSPREP00000006826	ENSPREP00000000043	F-box and leucine rich repeat protein 14.	F-box and leucine-rich repeat protein 18.	0.455
FBXL14	fbxo25	ENSPREP00000006826	ENSPREP00000002195	F-box and leucine rich repeat protein 14.	F-box protein 25.	0.462