(48 nodes) Deacetylase activity network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Sirt7	Uncharacterized protein. (134 aa)
	ENSPREP00000001955	Uncharacterized protein. (147 aa)
	LOC103467053	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (821 aa)
	LOC103458631	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	LOC103464932	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (923 aa)
	hdac9	Histone deacetylase 9b. (631 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (311 aa)
	sirt1	Sirtuin 1. (677 aa)
	ENSPREP00000004470	Uncharacterized protein. (64 aa)
	ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1a. (889 aa)
	ENSPREP00000005178	Uncharacterized protein. (82 aa)
	ccdc96	DUF4201 domain-containing protein. (451 aa)
	oard1	O-acyl-ADP-ribose deacylase 1. (210 aa)
	adprhl2	ADP-ribosylhydrolase like 2. (383 aa)
	hdac5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1136 aa)
	LOC103479554	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (315 aa)
	ENSPREP00000009110	Macro domain-containing protein. (171 aa)
	ENSPREP00000009131	Uncharacterized protein. (100 aa)
	pigl	Phosphatidylinositol glycan anchor biosynthesis, class L. (283 aa)
	Macrod2	Uncharacterized protein. (241 aa)
	ENSPREP00000010060	Uncharacterized protein. (139 aa)
	ndst2	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2a. (903 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (385 aa)
	LOC103467328	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3. (879 aa)
	ENSPREP00000013659	Uncharacterized protein. (91 aa)
	sirt5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (326 aa)
	ENSPREP00000015009	Macro domain-containing protein. (145 aa)
	hdac8	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (435 aa)
	ydjc	YdjC chitooligosaccharide deacetylase homolog. (310 aa)
	amdhd2	N-acetylglucosamine-6-phosphate deacetylase; Belongs to the metallo-dependent hydrolases superfamily. NagA family. (406 aa)
	ENSPREP00000018054	Macro domain-containing protein. (113 aa)
	hdac6	Histone deacetylase 6. (899 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1105 aa)
	LOC103474968	Histone deacetylase 12. (345 aa)
	LOC108165944	Uncharacterized protein. (208 aa)
	macrod1	Mono-ADP ribosylhydrolase 1. (366 aa)
	LOC103461731	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1063 aa)
	LOC103472045	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	ENSPREP00000025112	Macro domain-containing protein. (173 aa)
	ENSPREP00000025121	Sirtuin 3. (152 aa)
	LOC103466083	Si:dkey-103i16.6. (445 aa)
	LOC103479463	Sirtuin 6. (339 aa)
	hdac10	Histone deacetylase 10. (665 aa)
	ENSPREP00000029409	Uncharacterized protein. (198 aa)
	hdac11	Histone deacetylase 11. (367 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (458 aa)
	ENSPREP00000033119	Uncharacterized protein. (181 aa)
	ENSPREP00000034200	Uncharacterized protein. (73 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000001955	ENSPREP00000005178	ENSPREP00000001955	ENSPREP00000005178	Uncharacterized protein.	Uncharacterized protein.	0.521
ENSPREP00000001955	ENSPREP00000009131	ENSPREP00000001955	ENSPREP00000009131	Uncharacterized protein.	Uncharacterized protein.	0.533
ENSPREP00000001955	ENSPREP00000013659	ENSPREP00000001955	ENSPREP00000013659	Uncharacterized protein.	Uncharacterized protein.	0.512
ENSPREP00000001955	ENSPREP00000034200	ENSPREP00000001955	ENSPREP00000034200	Uncharacterized protein.	Uncharacterized protein.	0.531
ENSPREP00000004470	HDAC4	ENSPREP00000004470	ENSPREP00000018575	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.441
ENSPREP00000004470	LOC103461731	ENSPREP00000004470	ENSPREP00000024983	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.441
ENSPREP00000004470	LOC103464932	ENSPREP00000004470	ENSPREP00000002559	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.441
ENSPREP00000004470	LOC103467053	ENSPREP00000004470	ENSPREP00000002291	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.441
ENSPREP00000004470	LOC103479463	ENSPREP00000004470	ENSPREP00000026036	Uncharacterized protein.	Sirtuin 6.	0.402
ENSPREP00000004470	LOC103479554	ENSPREP00000004470	ENSPREP00000008857	Uncharacterized protein.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.427
ENSPREP00000004470	ccdc96	ENSPREP00000004470	ENSPREP00000007097	Uncharacterized protein.	DUF4201 domain-containing protein.	0.427
ENSPREP00000004470	hdac10	ENSPREP00000004470	ENSPREP00000028114	Uncharacterized protein.	Histone deacetylase 10.	0.441
ENSPREP00000004470	hdac5	ENSPREP00000004470	ENSPREP00000008588	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.441
ENSPREP00000004470	hdac6	ENSPREP00000004470	ENSPREP00000018344	Uncharacterized protein.	Histone deacetylase 6.	0.441
ENSPREP00000004470	hdac9	ENSPREP00000004470	ENSPREP00000002660	Uncharacterized protein.	Histone deacetylase 9b.	0.441
ENSPREP00000004470	sirt1	ENSPREP00000004470	ENSPREP00000003960	Uncharacterized protein.	Sirtuin 1.	0.575
ENSPREP00000004470	sirt2	ENSPREP00000004470	ENSPREP00000012959	Uncharacterized protein.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.513
ENSPREP00000004470	sirt5	ENSPREP00000004470	ENSPREP00000014162	Uncharacterized protein.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.427
ENSPREP00000005178	ENSPREP00000001955	ENSPREP00000005178	ENSPREP00000001955	Uncharacterized protein.	Uncharacterized protein.	0.521
ENSPREP00000005178	ENSPREP00000018054	ENSPREP00000005178	ENSPREP00000018054	Uncharacterized protein.	Macro domain-containing protein.	0.517