(23 nodes) Sensory perception of pain network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	phf24	PHD finger protein 24. (402 aa)
	Lxn	Spondin domain-containing protein. (87 aa)
	mc1r	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (314 aa)
	LOC103460568	PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (349 aa)
	LOC103460628	Opiate receptor-like 1; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	oprk1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	aqp1	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
	ENSPREP00000010780	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (176 aa)
	cdk5	Cyclin-dependent kinase 5. (262 aa)
	KCNK4	Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (326 aa)
	penk	Uncharacterized protein. (246 aa)
	mecp2	Methyl CpG binding protein 2. (982 aa)
	p2rx7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (580 aa)
	tac1	Tachykinin 1. (107 aa)
	LOC103476310	Transmembrane protein 120A. (347 aa)
	prdm12	PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (379 aa)
	LOC103471448	Potassium channel, subfamily K, member 4a; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (492 aa)
	LOC103479830	Opioid receptor, kappa 1; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	trpa1	Transient receptor potential cation channel, subfamily A, member 1b; Belongs to the transient receptor (TC 1.A.4) family. (1117 aa)
	ENSPREP00000029608	CALCITONIN domain-containing protein. (104 aa)
	retreg1	Reticulophagy regulator 1. (336 aa)
	ptges	Prostaglandin E synthase. (150 aa)
	pawr	PRKC, apoptosis, WT1, regulator. (280 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103460628	LOC103479830	ENSPREP00000006972	ENSPREP00000023933	Opiate receptor-like 1; Belongs to the G-protein coupled receptor 1 family.	Opioid receptor, kappa 1; Belongs to the G-protein coupled receptor 1 family.	0.494
LOC103460628	oprk1	ENSPREP00000006972	ENSPREP00000009861	Opiate receptor-like 1; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.491
LOC103460628	penk	ENSPREP00000006972	ENSPREP00000017744	Opiate receptor-like 1; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.936
LOC103479830	LOC103460628	ENSPREP00000023933	ENSPREP00000006972	Opioid receptor, kappa 1; Belongs to the G-protein coupled receptor 1 family.	Opiate receptor-like 1; Belongs to the G-protein coupled receptor 1 family.	0.494
LOC103479830	mecp2	ENSPREP00000023933	ENSPREP00000018569	Opioid receptor, kappa 1; Belongs to the G-protein coupled receptor 1 family.	Methyl CpG binding protein 2.	0.689
LOC103479830	penk	ENSPREP00000023933	ENSPREP00000017744	Opioid receptor, kappa 1; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.869
mecp2	LOC103479830	ENSPREP00000018569	ENSPREP00000023933	Methyl CpG binding protein 2.	Opioid receptor, kappa 1; Belongs to the G-protein coupled receptor 1 family.	0.689
mecp2	oprk1	ENSPREP00000018569	ENSPREP00000009861	Methyl CpG binding protein 2.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.470
oprk1	LOC103460628	ENSPREP00000009861	ENSPREP00000006972	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Opiate receptor-like 1; Belongs to the G-protein coupled receptor 1 family.	0.491
oprk1	mecp2	ENSPREP00000009861	ENSPREP00000018569	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Methyl CpG binding protein 2.	0.470
oprk1	penk	ENSPREP00000009861	ENSPREP00000017744	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.869
penk	LOC103460628	ENSPREP00000017744	ENSPREP00000006972	Uncharacterized protein.	Opiate receptor-like 1; Belongs to the G-protein coupled receptor 1 family.	0.936
penk	LOC103479830	ENSPREP00000017744	ENSPREP00000023933	Uncharacterized protein.	Opioid receptor, kappa 1; Belongs to the G-protein coupled receptor 1 family.	0.869
penk	oprk1	ENSPREP00000017744	ENSPREP00000009861	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.869
penk	tac1	ENSPREP00000017744	ENSPREP00000019280	Uncharacterized protein.	Tachykinin 1.	0.556
tac1	penk	ENSPREP00000019280	ENSPREP00000017744	Tachykinin 1.	Uncharacterized protein.	0.556
tac1	trpa1	ENSPREP00000019280	ENSPREP00000026537	Tachykinin 1.	Transient receptor potential cation channel, subfamily A, member 1b; Belongs to the transient receptor (TC 1.A.4) family.	0.476
trpa1	tac1	ENSPREP00000026537	ENSPREP00000019280	Transient receptor potential cation channel, subfamily A, member 1b; Belongs to the transient receptor (TC 1.A.4) family.	Tachykinin 1.	0.476