(47 nodes) Limbic system development network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	lef1	Lymphoid enhancer-binding factor 1. (422 aa)
	LOC103477979	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (374 aa)
	bbs1	Bardet-Biedl syndrome 1. (583 aa)
	btg1	B-cell translocation gene 1, anti-proliferative. (148 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (811 aa)
	ENSPREP00000006666	BHLH domain-containing protein. (76 aa)
	LOC103471204	Ubiquinol-cytochrome c reductase, complex III subunit VII. (82 aa)
	tmem108	Transmembrane protein 108. (416 aa)
	SRF	Serum response factor. (243 aa)
	LOC103457458	Uncharacterized protein. (763 aa)
	bbs4	Bardet-Biedl syndrome 4. (520 aa)
	crkl	V-crk avian sarcoma virus CT10 oncogene homolog-like. (310 aa)
	mkks	McKusick-Kaufman syndrome. (576 aa)
	ENSPREP00000011364	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1074 aa)
	cdk5	Cyclin-dependent kinase 5. (262 aa)
	LOC103473007	Cyclin-dependent kinase 5 activator. (321 aa)
	srf	Serum response factor b. (570 aa)
	BAX	BCL2 associated X, apoptosis regulator. (191 aa)
	crk	CRK proto-oncogene, adaptor protein. (315 aa)
	nf2	Neurofibromin 2b (merlin). (615 aa)
	hsd3b7	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; Belongs to the 3-beta-HSD family. (367 aa)
	LOC103468291	Cyclin-dependent kinase 5 activator. (334 aa)
	fez1	Fasciculation and elongation protein zeta 1 (zygin I). (398 aa)
	ENSPREP00000018724	Uncharacterized protein. (624 aa)
	cdk5r1	Cyclin-dependent kinase 5 activator. (450 aa)
	nf1	Neurofibromin 1b. (2742 aa)
	LOC103482434	Forkhead box H1. (633 aa)
	LOC103461155	Neurofibromin 2a (merlin). (394 aa)
	ENSPREP00000023272	Uncharacterized protein. (267 aa)
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (619 aa)
	LOC103460449	Neuropilin; Belongs to the neuropilin family. (936 aa)
	ENSPREP00000023825	SH2 domain-containing protein. (93 aa)
	RELN	Reelin. (3446 aa)
	ENSPREP00000025759	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
	LOC103478724	Aryl hydrocarbon receptor nuclear translocator. (761 aa)
	SIM1	SIM bHLH transcription factor 1a. (740 aa)
	rax	Retinal homeobox gene 3. (310 aa)
	ndnf	Neuron-derived neurotrophic factor. (571 aa)
	LOC103477609	Brevican. (1226 aa)
	otp	Orthopedia homeobox. (326 aa)
	fezf2	FEZ family zinc finger 2. (346 aa)
	tsc1	TSC complex subunit 1b. (1243 aa)
	LOC103472829	Uncharacterized protein. (298 aa)
	arnt2	Aryl-hydrocarbon receptor nuclear translocator 2. (679 aa)
	lgr4	Leucine-rich repeat containing G protein-coupled receptor 4. (913 aa)
	dcx	Uncharacterized protein. (359 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000006666	LOC103478724	ENSPREP00000006666	ENSPREP00000025818	BHLH domain-containing protein.	Aryl hydrocarbon receptor nuclear translocator.	0.704
ENSPREP00000006666	arnt2	ENSPREP00000006666	ENSPREP00000033074	BHLH domain-containing protein.	Aryl-hydrocarbon receptor nuclear translocator 2.	0.704
ENSPREP00000018724	LOC103472829	ENSPREP00000018724	ENSPREP00000032287	Uncharacterized protein.	Uncharacterized protein.	0.892
ENSPREP00000023272	LOC103468291	ENSPREP00000023272	ENSPREP00000017469	Uncharacterized protein.	Cyclin-dependent kinase 5 activator.	0.418
ENSPREP00000023272	LOC103473007	ENSPREP00000023272	ENSPREP00000012825	Uncharacterized protein.	Cyclin-dependent kinase 5 activator.	0.422
ENSPREP00000023272	cdk5	ENSPREP00000023272	ENSPREP00000011776	Uncharacterized protein.	Cyclin-dependent kinase 5.	0.928
ENSPREP00000023272	cdk5r1	ENSPREP00000023272	ENSPREP00000018796	Uncharacterized protein.	Cyclin-dependent kinase 5 activator.	0.412
ENSPREP00000023825	crk	ENSPREP00000023825	ENSPREP00000013741	SH2 domain-containing protein.	CRK proto-oncogene, adaptor protein.	0.901
ENSPREP00000023825	crkl	ENSPREP00000023825	ENSPREP00000009681	SH2 domain-containing protein.	V-crk avian sarcoma virus CT10 oncogene homolog-like.	0.909
ENSPREP00000025759	lef1	ENSPREP00000025759	ENSPREP00000003479	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Lymphoid enhancer-binding factor 1.	0.433
LOC103457458	LOC103478724	ENSPREP00000009334	ENSPREP00000025818	Uncharacterized protein.	Aryl hydrocarbon receptor nuclear translocator.	0.704
LOC103457458	arnt2	ENSPREP00000009334	ENSPREP00000033074	Uncharacterized protein.	Aryl-hydrocarbon receptor nuclear translocator 2.	0.704
LOC103461155	nf1	ENSPREP00000023162	ENSPREP00000021407	Neurofibromin 2a (merlin).	Neurofibromin 1b.	0.477
LOC103461155	nf2	ENSPREP00000023162	ENSPREP00000014172	Neurofibromin 2a (merlin).	Neurofibromin 2b (merlin).	0.901
LOC103468291	ENSPREP00000023272	ENSPREP00000017469	ENSPREP00000023272	Cyclin-dependent kinase 5 activator.	Uncharacterized protein.	0.418
LOC103468291	cdk5	ENSPREP00000017469	ENSPREP00000011776	Cyclin-dependent kinase 5 activator.	Cyclin-dependent kinase 5.	0.928
LOC103472829	ENSPREP00000018724	ENSPREP00000032287	ENSPREP00000018724	Uncharacterized protein.	Uncharacterized protein.	0.892
LOC103473007	ENSPREP00000023272	ENSPREP00000012825	ENSPREP00000023272	Cyclin-dependent kinase 5 activator.	Uncharacterized protein.	0.422
LOC103473007	cdk5	ENSPREP00000012825	ENSPREP00000011776	Cyclin-dependent kinase 5 activator.	Cyclin-dependent kinase 5.	0.928
LOC103478724	ENSPREP00000006666	ENSPREP00000025818	ENSPREP00000006666	Aryl hydrocarbon receptor nuclear translocator.	BHLH domain-containing protein.	0.704