(117 nodes) Neural tube development network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPREP00000000846	Ring finger protein 220a. (258 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	prkaca	Uncharacterized protein; Belongs to the protein kinase superfamily. (327 aa)
	pkd1	Polycystic kidney disease 1a. (4592 aa)
	tsc2	TSC complex subunit 2. (1898 aa)
	notum	Uncharacterized protein. (419 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (226 aa)
	RNF220	Uncharacterized protein. (239 aa)
	ENSPREP00000001242	DIX domain-containing protein. (55 aa)
	LOC103458615	NK2 homeobox 2a. (335 aa)
	VANGL2	VANGL planar cell polarity protein 2. (691 aa)
	ENSPREP00000001400	Uncharacterized protein. (444 aa)
	LOC103481447	Paired box 2b. (392 aa)
	dlx5	Distal-less homeobox 5a. (286 aa)
	dlx6	Distal-less homeobox 6a. (246 aa)
	LOC103468852	Notum, palmitoleoyl-protein carboxylesterase a. (500 aa)
	deaf1	DEAF1 transcription factor. (468 aa)
	LOC103459232	Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (405 aa)
	LOC103482193	Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (506 aa)
	hectd1	HECT domain containing 1. (2572 aa)
	slc7a6os	Solute carrier family 7 member 6 opposite strand. (400 aa)
	Ferd3l	Fer3-like bHLH transcription factor. (66 aa)
	dvl1	Dishevelled segment polarity protein 1a. (653 aa)
	phgdh	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (527 aa)
	mthfd1l	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (695 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (811 aa)
	LOC103468785	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
	LOC103459284	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (865 aa)
	scrib	Scribble planar cell polarity protein. (1718 aa)
	LOC103479553	Phosphatase and actin regulator. (548 aa)
	arl13b	ADP-ribosylation factor-like 13b. (405 aa)
	bbs4	Bardet-Biedl syndrome 4. (520 aa)
	LOC103466630	Peptidylprolyl isomerase. (467 aa)
	pax5	Paired box 5. (396 aa)
	wdr19	WD repeat domain 19. (1343 aa)
	LOC103470543	Transcription factor 7 like 1b. (612 aa)
	LOC103473609	POU domain protein. (513 aa)
	glmn	Glomulin, FKBP associated protein a. (611 aa)
	LOC103462620	Uncharacterized protein. (254 aa)
	LOC103478449	Phosphatase and actin regulator. (879 aa)
	LOC103476180	Homeobox protein engrailed-like. (284 aa)
	LOC103480354	Vang-like protein. (525 aa)
	mpp5	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (650 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1042 aa)
	ccdc85b	Coiled-coil domain containing 85B. (200 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (427 aa)
	fkbp8	Peptidylprolyl isomerase. (396 aa)
	mthfr	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (645 aa)
	ENSPREP00000013704	Uncharacterized protein. (155 aa)
	LOC103460864	Uncharacterized protein; Belongs to the MAGUK family. (538 aa)
	LOC103460865	Coiled-coil domain containing 88C. (1316 aa)
	LOC103479663	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
	LOC103463401	Phosphatase and actin regulator. (570 aa)
	LOC103475798	Lysine (K)-specific demethylase 6A, like. (1466 aa)
	otx2	Orthodenticle homeobox 2b. (290 aa)
	rest	RE1-silencing transcription factor. (902 aa)
	cnpy1	Canopy FGF signaling regulator 1. (220 aa)
	LOC103478362	Cordon-bleu WH2 repeat protein. (1443 aa)
	ENSPREP00000017507	ANK_REP_REGION domain-containing protein. (191 aa)
	dvl2	Dishevelled segment polarity protein 2. (763 aa)
	LOC103473136	HMG box domain-containing protein. (551 aa)
	ENSPREP00000018776	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (824 aa)
	LOC103457124	Serine peptidase inhibitor, Kunitz type 1 b. (500 aa)
	gbx2	Gastrulation brain homeobox 2. (339 aa)
	nr6a1	Nuclear receptor subfamily 6, group A, member 1a. (458 aa)
	prkci	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
	LOC103461021	Homeobox protein engrailed-like. (226 aa)
	LOC103479347	Dishevelled segment polarity protein 3a. (457 aa)
	ENSPREP00000020826	DIX domain-containing protein. (54 aa)
	LOC103461065	DUF1619 domain-containing protein. (354 aa)
	abl1	Tyrosine-protein kinase. (1124 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
	nf1	Neurofibromin 1b. (2742 aa)
	LOC103471985	Phosphatase and actin regulator 4a. (1141 aa)
	LOC103482434	Forkhead box H1. (633 aa)
	pax8	Paired box 8. (495 aa)
	LOC103482469	Homeobox protein engrailed-like. (283 aa)
	LOC103457903	Homeobox domain-containing protein. (307 aa)
	cthrc1	Collagen triple helix repeat containing 1b. (230 aa)
	ENSPREP00000023776	Ring finger protein 220b. (280 aa)
	cdc42se1	CDC42 small effector 1. (107 aa)
	tmed2	Transmembrane p24 trafficking protein 2. (207 aa)
	fuz	Fuzzy planar cell polarity protein. (432 aa)
	ENSPREP00000025214	Paired domain-containing protein. (156 aa)
	Mib1	Mindbomb E3 ubiquitin protein ligase 1. (994 aa)
	mks1	MKS transition zone complex subunit 1. (540 aa)
	LOC103476847	Paired box 2a. (322 aa)
	ift52	Intraflagellar transport 52 homolog (Chlamydomonas). (404 aa)
	trim71	Tripartite motif containing 71, E3 ubiquitin protein ligase. (831 aa)
	abl2	Tyrosine-protein kinase. (1187 aa)
	LOC103475119	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	ift140	Intraflagellar transport 140 homolog (Chlamydomonas). (1435 aa)
	LOC103467447	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	LOC103474475	Uncharacterized protein. (342 aa)
	LOC103473327	HMG box domain-containing protein. (452 aa)
	LOC103476521	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC103473336	HMG box domain-containing protein. (458 aa)
	LOC103481180	Bromo domain-containing protein. (1323 aa)
	rpgrip1l	RPGRIP1 like. (1044 aa)
	kdm6a	Lysine (K)-specific demethylase 6A. (1447 aa)
	ambra1	Autophagy/beclin-1 regulator 1b. (1210 aa)
	ENSPREP00000030719	Uncharacterized protein. (708 aa)
	wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	LOC103481197	Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (412 aa)
	sall4	Spalt-like transcription factor 4. (1082 aa)
	LOC103464268	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (211 aa)
	spint1	Serine peptidase inhibitor, Kunitz type 1 a. (488 aa)
	tsc1	TSC complex subunit 1b. (1243 aa)
	mthfd1	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (934 aa)
	lrrc1	Leucine rich repeat containing 1. (522 aa)
	LOC103470962	Hairy-related 5. (194 aa)
	sema3c	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Belongs to the semaphorin family. (746 aa)
	tctn1	DUF1619 domain-containing protein. (519 aa)
	rnf152	Ring finger protein 152. (177 aa)
	ppp1r12a	Protein phosphatase 1 regulatory subunit. (1113 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH2	abl1	ENSPREP00000007079	ENSPREP00000021197	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Tyrosine-protein kinase.	0.414
CDH2	abl2	ENSPREP00000007079	ENSPREP00000026823	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Tyrosine-protein kinase.	0.414
ENSPREP00000000846	ENSPREP00000023776	ENSPREP00000000846	ENSPREP00000023776	Ring finger protein 220a.	Ring finger protein 220b.	0.900
ENSPREP00000000846	RNF220	ENSPREP00000000846	ENSPREP00000000871	Ring finger protein 220a.	Uncharacterized protein.	0.900
ENSPREP00000001242	ENSPREP00000020826	ENSPREP00000001242	ENSPREP00000020826	DIX domain-containing protein.	DIX domain-containing protein.	0.901
ENSPREP00000001242	LOC103459284	ENSPREP00000001242	ENSPREP00000006858	DIX domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.539
ENSPREP00000001242	LOC103467447	ENSPREP00000001242	ENSPREP00000028159	DIX domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.539
ENSPREP00000001242	LOC103474475	ENSPREP00000001242	ENSPREP00000028750	DIX domain-containing protein.	Uncharacterized protein.	0.441
ENSPREP00000001242	LOC103480354	ENSPREP00000001242	ENSPREP00000012627	DIX domain-containing protein.	Vang-like protein.	0.956
ENSPREP00000001242	VANGL2	ENSPREP00000001242	ENSPREP00000001301	DIX domain-containing protein.	VANGL planar cell polarity protein 2.	0.956
ENSPREP00000001242	dvl2	ENSPREP00000001242	ENSPREP00000018043	DIX domain-containing protein.	Dishevelled segment polarity protein 2.	0.910
ENSPREP00000001242	sfrp2	ENSPREP00000001242	ENSPREP00000000067	DIX domain-containing protein.	Secreted frizzled-related protein 2.	0.441
ENSPREP00000001242	smo	ENSPREP00000001242	ENSPREP00000005932	DIX domain-containing protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.432
ENSPREP00000001242	wnt1	ENSPREP00000001242	ENSPREP00000031027	DIX domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.552
ENSPREP00000001400	LOC103459284	ENSPREP00000001400	ENSPREP00000006858	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.539
ENSPREP00000001400	LOC103467447	ENSPREP00000001400	ENSPREP00000028159	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.539
ENSPREP00000001400	LOC103474475	ENSPREP00000001400	ENSPREP00000028750	Uncharacterized protein.	Uncharacterized protein.	0.441
ENSPREP00000001400	LOC103480354	ENSPREP00000001400	ENSPREP00000012627	Uncharacterized protein.	Vang-like protein.	0.585
ENSPREP00000001400	VANGL2	ENSPREP00000001400	ENSPREP00000001301	Uncharacterized protein.	VANGL planar cell polarity protein 2.	0.585
ENSPREP00000001400	sfrp2	ENSPREP00000001400	ENSPREP00000000067	Uncharacterized protein.	Secreted frizzled-related protein 2.	0.441