(97 nodes) Positive regulation of Wnt signaling pathway network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	usp8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1075 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1357 aa)
	LOC103474628	Protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative). (435 aa)
	lgr4	Leucine-rich repeat containing G protein-coupled receptor 4. (913 aa)
	sulf2	Sulfatase 2a. (819 aa)
	ENSPREP00000032877	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (330 aa)
	LOC103461950	Glypican 5a; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (563 aa)
	ENSPREP00000031676	Glypican 5b; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (517 aa)
	xiap	X-linked inhibitor of apoptosis. (435 aa)
	zc3h12b	APC membrane recruitment protein 1. (986 aa)
	USP34	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (2838 aa)
	ENSPREP00000030224	PID domain-containing protein. (124 aa)
	LOC103470892	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
	LOC103470891	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	LOC103476521	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC103469721	Poly [ADP-ribose] polymerase. (1263 aa)
	LGR6	Leucine rich repeat containing G protein-coupled receptor 6. (938 aa)
	LOC103474475	Uncharacterized protein. (342 aa)
	LOC103467447	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	sulf1	Sulfatase 1. (1148 aa)
	abl2	Tyrosine-protein kinase. (1187 aa)
	gid8	GID complex subunit 8 homolog b (S. cerevisiae). (228 aa)
	LOC103479401	Glypican 5c; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (608 aa)
	LOC103468446	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
	LOC103481034	Casein kinase 1, epsilon; Belongs to the protein kinase superfamily. (401 aa)
	ubr5	Ubiquitin protein ligase E3 component n-recognin 5. (2851 aa)
	ENSPREP00000023776	Ring finger protein 220b. (280 aa)
	LOC103464120	RING-type domain-containing protein. (282 aa)
	ppm1a	Protein phosphatase, Mg2+/Mn2+ dependent, 1Aa. (407 aa)
	nle1	Notchless homolog 1 (Drosophila). (478 aa)
	rspo2	R-spondin 2. (245 aa)
	LOC103480964	Dickkopf_N domain-containing protein. (205 aa)
	LOC103465322	DUF4203 domain-containing protein. (341 aa)
	ilk	Uncharacterized protein. (465 aa)
	abl1	Tyrosine-protein kinase. (1124 aa)
	tmem198	Transmembrane protein 198b. (393 aa)
	reck	Reversion-inducing-cysteine-rich protein with kazal motifs. (974 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (515 aa)
	ctnnb1	Catenin (cadherin-associated protein), beta 1. (783 aa)
	LOC103478337	R-spondin 3. (325 aa)
	bambi	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a. (278 aa)
	RNF146	Ring finger protein 146. (388 aa)
	LOC103457724	Ring finger protein 146. (362 aa)
	ENSPREP00000017955	C1q domain-containing protein. (310 aa)
	wnt3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (443 aa)
	LOC103476755	Zinc finger, RAN-binding domain containing 1b. (771 aa)
	FAM53B	Family with sequence similarity 53 member B. (438 aa)
	LOC103461633	Transmembrane protein 198a. (391 aa)
	LOC103479254	Protein kinase domain-containing protein. (505 aa)
	ENSPREP00000014417	WNK lysine deficient protein kinase 2. (1538 aa)
	PRDM15	PR/SET domain 15. (1117 aa)
	LOC103465217	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (159 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1042 aa)
	LOC103480354	Vang-like protein. (525 aa)
	ILK	Integrin linked kinase. (452 aa)
	ENSPREP00000012400	Uncharacterized protein. (550 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (799 aa)
	LOC103468226	Casein kinase 1 gamma 2. (515 aa)
	wls	Wnt ligand secretion mediator. (448 aa)
	LOC103465114	WNK lysine deficient protein kinase 2. (2243 aa)
	LYPD6	LY6/PLAUR domain containing 6. (179 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	ttc21b	Tetratricopeptide repeat domain 21B. (1317 aa)
	atp6ap2	ATPase H+ transporting accessory protein 2. (381 aa)
	adgra2	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1383 aa)
	csnk1d	Casein kinase 1, delta b; Belongs to the protein kinase superfamily. (389 aa)
	LOC103469200	G protein-coupled receptor, class C, group 5, member Ba. (397 aa)
	LOC103481573	Family with sequence similarity 53 member B. (393 aa)
	LOC103481570	Uncharacterized protein. (742 aa)
	LOC103479069	Transducin (beta)-like 1 X-linked receptor 1b. (514 aa)
	csnk1g1	Casein kinase 1, gamma 1; Belongs to the protein kinase superfamily. (466 aa)
	rspo1	R-spondin 1. (273 aa)
	LOC103473565	Poly [ADP-ribose] polymerase. (1285 aa)
	LGR5	Leucine rich repeat containing G protein-coupled receptor 5. (787 aa)
	cdc73	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (576 aa)
	ENSPREP00000007878	Sulfatase domain-containing protein. (248 aa)
	eda	Ectodysplasin A; Belongs to the tumor necrosis factor family. (369 aa)
	LOC103481540	Protein phosphatase, Mg2+/Mn2+ dependent, 1Bb. (469 aa)
	LOC103459284	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2573 aa)
	ppm1b	Protein phosphatase, Mg2+/Mn2+ dependent, 1Ba. (380 aa)
	Cav1	Uncharacterized protein. (84 aa)
	dkk2	Dickkopf WNT signaling pathway inhibitor 2. (242 aa)
	lef1	Lymphoid enhancer-binding factor 1. (422 aa)
	LOC103473454	Huluwa. (201 aa)
	lrrk1	Uncharacterized protein. (2016 aa)
	LOC103467734	Uncharacterized protein. (229 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
	LOC103459281	Transducin beta like 1 X-linked. (513 aa)
	ankrd6	Ankyrin repeat domain 6. (768 aa)
	VANGL2	VANGL planar cell polarity protein 2. (691 aa)
	LOC103467771	DUF4203 domain-containing protein. (336 aa)
	RNF220	Uncharacterized protein. (239 aa)
	ENSPREP00000000846	Ring finger protein 220a. (258 aa)
	gprc5b	G protein-coupled receptor, class C, group 5, member Bb. (419 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (156 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cav1	ctnnb1	ENSPREP00000003891	ENSPREP00000019419	Uncharacterized protein.	Catenin (cadherin-associated protein), beta 1.	0.679
Cav1	wnt3	ENSPREP00000003891	ENSPREP00000017531	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.585
Cav1	wnt3a	ENSPREP00000003891	ENSPREP00000011284	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.585
ENSPREP00000000846	ENSPREP00000023776	ENSPREP00000000846	ENSPREP00000023776	Ring finger protein 220a.	Ring finger protein 220b.	0.900
ENSPREP00000000846	RNF220	ENSPREP00000000846	ENSPREP00000000871	Ring finger protein 220a.	Uncharacterized protein.	0.900
ENSPREP00000023776	ENSPREP00000000846	ENSPREP00000023776	ENSPREP00000000846	Ring finger protein 220b.	Ring finger protein 220a.	0.900
ENSPREP00000023776	LOC103464120	ENSPREP00000023776	ENSPREP00000023754	Ring finger protein 220b.	RING-type domain-containing protein.	0.864
ENSPREP00000030224	LOC103459284	ENSPREP00000030224	ENSPREP00000006858	PID domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.475
ENSPREP00000030224	LOC103467447	ENSPREP00000030224	ENSPREP00000028159	PID domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.475
ILK	ilk	ENSPREP00000012407	ENSPREP00000021435	Integrin linked kinase.	Uncharacterized protein.	0.901
LGR5	LOC103478337	ENSPREP00000008461	ENSPREP00000019049	Leucine rich repeat containing G protein-coupled receptor 5.	R-spondin 3.	0.826
LGR5	rspo1	ENSPREP00000008461	ENSPREP00000008831	Leucine rich repeat containing G protein-coupled receptor 5.	R-spondin 1.	0.937
LGR5	rspo2	ENSPREP00000008461	ENSPREP00000022195	Leucine rich repeat containing G protein-coupled receptor 5.	R-spondin 2.	0.652
LGR5	wnt3a	ENSPREP00000008461	ENSPREP00000011284	Leucine rich repeat containing G protein-coupled receptor 5.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.405
LGR6	LOC103478337	ENSPREP00000029246	ENSPREP00000019049	Leucine rich repeat containing G protein-coupled receptor 6.	R-spondin 3.	0.935
LGR6	lgr4	ENSPREP00000029246	ENSPREP00000033484	Leucine rich repeat containing G protein-coupled receptor 6.	Leucine-rich repeat containing G protein-coupled receptor 4.	0.926
LGR6	rspo1	ENSPREP00000029246	ENSPREP00000008831	Leucine rich repeat containing G protein-coupled receptor 6.	R-spondin 1.	0.971
LGR6	rspo2	ENSPREP00000029246	ENSPREP00000022195	Leucine rich repeat containing G protein-coupled receptor 6.	R-spondin 2.	0.928
LOC103457724	LOC103469721	ENSPREP00000018472	ENSPREP00000029282	Ring finger protein 146.	Poly [ADP-ribose] polymerase.	0.853
LOC103457724	LOC103473565	ENSPREP00000018472	ENSPREP00000008753	Ring finger protein 146.	Poly [ADP-ribose] polymerase.	0.895