(69 nodes) T cell differentiation network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SP3	Sp3a transcription factor. (699 aa)
	tcf7	Transcription factor 7. (453 aa)
	LOC103458727	Sp3b transcription factor. (680 aa)
	ENSPREP00000032595	Proteasome subunit beta. (290 aa)
	ENSPREP00000032134	Forkhead box N1. (482 aa)
	ptger4	Prostaglandin E receptor 4 (subtype EP4) b. (456 aa)
	tsc1	TSC complex subunit 1b. (1243 aa)
	LOC103470093	Homeobox domain-containing protein. (363 aa)
	traf3ip2	SEFIR domain-containing protein. (418 aa)
	LOC103465012	Ig-like domain-containing protein. (203 aa)
	jak1	Tyrosine-protein kinase. (1174 aa)
	batf	Basic leucine zipper transcription factor, ATF-like. (124 aa)
	nkx2-3	NK2 homeobox 3. (349 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	agtpbp1	ATP/GTP binding protein 1. (1264 aa)
	rag2	Recombination activating gene 2. (533 aa)
	rag1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (994 aa)
	LOC103479948	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
	LOC103468544	Guanylate kinase-like domain-containing protein. (308 aa)
	ENSPREP00000027430	CARD domain-containing protein. (524 aa)
	cd83	CD83 molecule. (228 aa)
	LOC103475119	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	LOC103463873	Proteasome subunit beta11b. (386 aa)
	abl2	Tyrosine-protein kinase. (1187 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
	ENSPREP00000026492	SEFIR domain-containing protein. (109 aa)
	rc3h1	Ring finger and CCCH-type domains 1b. (1119 aa)
	LOC103478148	Interleukin 6 receptor. (603 aa)
	ENSPREP00000022535	G_PROTEIN_RECEP_F1_2 domain-containing protein. (363 aa)
	ENSPREP00000022497	G_PROTEIN_RECEP_F1_2 domain-containing protein. (160 aa)
	ENSPREP00000022389	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (424 aa)
	rabl3	RAB, member of RAS oncogene family-like 3. (233 aa)
	LOC103466013	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (443 aa)
	abl1	Tyrosine-protein kinase. (1124 aa)
	zbtb1	Zinc finger and BTB domain containing 1. (681 aa)
	tbx21	T-box transcription factor 21. (614 aa)
	prr7	Proline rich 7 (synaptic). (294 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1230 aa)
	sash3	SAM and SH3 domain containing 3. (397 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1001 aa)
	ENSPREP00000016378	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (702 aa)
	lepr	Uncharacterized protein. (1121 aa)
	armc5	Armadillo repeat containing 5. (841 aa)
	tmem98	Transmembrane protein 98. (224 aa)
	rc3h2	Ring finger and CCCH-type domains 2. (1110 aa)
	srf	Serum response factor b. (570 aa)
	ENSPREP00000012469	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (487 aa)
	LOC103468233	Tyrosine-protein kinase. (606 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (522 aa)
	lig4	DNA ligase. (908 aa)
	LOC103474821	Uncharacterized protein. (175 aa)
	cd3e	Ig_4 domain-containing protein. (185 aa)
	LOC103475178	Ig_4 domain-containing protein. (169 aa)
	snx12	Fibronectin type-III domain-containing protein. (355 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (582 aa)
	LOC103474046	Fibronectin type-III domain-containing protein. (440 aa)
	Fzd8	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (556 aa)
	gpr18	G protein-coupled receptor 18. (339 aa)
	gpr183	G protein-coupled receptor 183a; Belongs to the G-protein coupled receptor 1 family. (386 aa)
	LOC103479168	Si:ch211-184m13.4; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	LOC103458658	Chemokine (C-C motif) receptor 6b; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	lef1	Lymphoid enhancer-binding factor 1. (422 aa)
	ENSPREP00000002275	DED domain-containing protein. (147 aa)
	SRF	Serum response factor. (243 aa)
	ENSPREP00000005271	Uncharacterized protein. (210 aa)
	LOC103475332	Interferon regulatory factor. (291 aa)
	ENSPREP00000005844	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	syk	Tyrosine-protein kinase. (614 aa)
	themis2	Thymocyte selection associated family member 2. (703 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000002275	LOC103466013	ENSPREP00000002275	ENSPREP00000021307	DED domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.991
ENSPREP00000002275	LOC103468233	ENSPREP00000002275	ENSPREP00000012417	DED domain-containing protein.	Tyrosine-protein kinase.	0.597
ENSPREP00000002275	atg5	ENSPREP00000002275	ENSPREP00000028618	DED domain-containing protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.749
ENSPREP00000002275	ripk2	ENSPREP00000002275	ENSPREP00000009886	DED domain-containing protein.	Receptor-interacting serine-threonine kinase 2.	0.710
ENSPREP00000002275	syk	ENSPREP00000002275	ENSPREP00000006334	DED domain-containing protein.	Tyrosine-protein kinase.	0.597
ENSPREP00000016378	Mtor	ENSPREP00000016378	ENSPREP00000016474	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.934
ENSPREP00000016378	atg5	ENSPREP00000016378	ENSPREP00000028618	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.456
ENSPREP00000016378	lig4	ENSPREP00000016378	ENSPREP00000010705	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	DNA ligase.	0.809
ENSPREP00000016378	stk11	ENSPREP00000016378	ENSPREP00000026606	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine kinase 11; Belongs to the protein kinase superfamily.	0.547
ENSPREP00000016378	tsc1	ENSPREP00000016378	ENSPREP00000032075	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	TSC complex subunit 1b.	0.882
ENSPREP00000026492	traf3ip2	ENSPREP00000026492	ENSPREP00000030465	SEFIR domain-containing protein.	SEFIR domain-containing protein.	0.900
ENSPREP00000027430	LOC103468233	ENSPREP00000027430	ENSPREP00000012417	CARD domain-containing protein.	Tyrosine-protein kinase.	0.511
ENSPREP00000027430	LOC103468544	ENSPREP00000027430	ENSPREP00000027446	CARD domain-containing protein.	Guanylate kinase-like domain-containing protein.	0.900
ENSPREP00000027430	ripk2	ENSPREP00000027430	ENSPREP00000009886	CARD domain-containing protein.	Receptor-interacting serine-threonine kinase 2.	0.489
ENSPREP00000027430	syk	ENSPREP00000027430	ENSPREP00000006334	CARD domain-containing protein.	Tyrosine-protein kinase.	0.478
ENSPREP00000032134	rag1	ENSPREP00000032134	ENSPREP00000028083	Forkhead box N1.	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]	0.541
ENSPREP00000032134	rag2	ENSPREP00000032134	ENSPREP00000028094	Forkhead box N1.	Recombination activating gene 2.	0.426
LOC103465012	LOC103468233	ENSPREP00000030428	ENSPREP00000012417	Ig-like domain-containing protein.	Tyrosine-protein kinase.	0.438
LOC103465012	LOC103474046	ENSPREP00000030428	ENSPREP00000009276	Ig-like domain-containing protein.	Fibronectin type-III domain-containing protein.	0.579
LOC103465012	LOC103474821	ENSPREP00000030428	ENSPREP00000010465	Ig-like domain-containing protein.	Uncharacterized protein.	0.924