(20 nodes) Megakaryocyte differentiation network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103468460	E1A binding protein p300 b. (2737 aa)
	ABI1	Abl-interactor 1a. (577 aa)
	ENSPREP00000003699	SH3 domain-containing protein. (137 aa)
	ENSPREP00000003717	Uncharacterized protein. (76 aa)
	SP3	Sp3a transcription factor. (699 aa)
	LOC103458727	Sp3b transcription factor. (680 aa)
	cdkn2b	Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (126 aa)
	SRF	Serum response factor. (243 aa)
	LOC103467580	Glycoprotein IX (platelet). (241 aa)
	srf	Serum response factor b. (570 aa)
	uba5	Ubiquitin-like modifier activating enzyme 5. (400 aa)
	ptpn6	Protein tyrosine phosphatase non-receptor type 6. (573 aa)
	LOC103467098	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	gp1bb	Glycoprotein Ib platelet subunit beta. (206 aa)
	LOC103460214	Uncharacterized protein. (269 aa)
	sh2b3	SH2B adaptor protein 3. (710 aa)
	ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
	zfpm1	Zinc finger protein, FOG family member 1. (1177 aa)
	LOC103482005	E1A binding protein p300 a. (2743 aa)
	LOC103465552	GATA binding protein 1a. (426 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103460214	LOC103468460	ENSPREP00000017910	ENSPREP00000026558	Uncharacterized protein.	E1A binding protein p300 b.	0.646
LOC103460214	LOC103482005	ENSPREP00000017910	ENSPREP00000030842	Uncharacterized protein.	E1A binding protein p300 a.	0.646
LOC103460214	SP3	ENSPREP00000017910	ENSPREP00000007503	Uncharacterized protein.	Sp3a transcription factor.	0.428
LOC103460214	zfpm1	ENSPREP00000017910	ENSPREP00000028795	Uncharacterized protein.	Zinc finger protein, FOG family member 1.	0.892
LOC103465552	LOC103468460	ENSPREP00000032805	ENSPREP00000026558	GATA binding protein 1a.	E1A binding protein p300 b.	0.646
LOC103465552	LOC103482005	ENSPREP00000032805	ENSPREP00000030842	GATA binding protein 1a.	E1A binding protein p300 a.	0.646
LOC103465552	SP3	ENSPREP00000032805	ENSPREP00000007503	GATA binding protein 1a.	Sp3a transcription factor.	0.428
LOC103465552	zfpm1	ENSPREP00000032805	ENSPREP00000028795	GATA binding protein 1a.	Zinc finger protein, FOG family member 1.	0.892
LOC103467098	ptpn11	ENSPREP00000016883	ENSPREP00000024560	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.901
LOC103467580	gp1bb	ENSPREP00000012254	ENSPREP00000017108	Glycoprotein IX (platelet).	Glycoprotein Ib platelet subunit beta.	0.976
LOC103468460	LOC103460214	ENSPREP00000026558	ENSPREP00000017910	E1A binding protein p300 b.	Uncharacterized protein.	0.646
LOC103468460	LOC103465552	ENSPREP00000026558	ENSPREP00000032805	E1A binding protein p300 b.	GATA binding protein 1a.	0.646
LOC103468460	LOC103482005	ENSPREP00000026558	ENSPREP00000030842	E1A binding protein p300 b.	E1A binding protein p300 a.	0.902
LOC103468460	zfpm1	ENSPREP00000026558	ENSPREP00000028795	E1A binding protein p300 b.	Zinc finger protein, FOG family member 1.	0.474
LOC103482005	LOC103460214	ENSPREP00000030842	ENSPREP00000017910	E1A binding protein p300 a.	Uncharacterized protein.	0.646
LOC103482005	LOC103465552	ENSPREP00000030842	ENSPREP00000032805	E1A binding protein p300 a.	GATA binding protein 1a.	0.646
LOC103482005	LOC103468460	ENSPREP00000030842	ENSPREP00000026558	E1A binding protein p300 a.	E1A binding protein p300 b.	0.902
LOC103482005	zfpm1	ENSPREP00000030842	ENSPREP00000028795	E1A binding protein p300 a.	Zinc finger protein, FOG family member 1.	0.474
SP3	LOC103460214	ENSPREP00000007503	ENSPREP00000017910	Sp3a transcription factor.	Uncharacterized protein.	0.428
SP3	LOC103465552	ENSPREP00000007503	ENSPREP00000032805	Sp3a transcription factor.	GATA binding protein 1a.	0.428