(41 nodes) Cholesterol transport network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	apom	Uncharacterized protein. (295 aa)
	lcat	Lecithin-cholesterol acyltransferase. (434 aa)
	LOC103475277	ATP-binding cassette, sub-family G (WHITE), member 1. (620 aa)
	spg11	SPG11 vesicle trafficking associated, spatacsin. (2269 aa)
	cetp	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (454 aa)
	LOC103460557	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (562 aa)
	ldlrap1	Low density lipoprotein receptor adaptor protein 1b. (287 aa)
	vps4a	Vacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family. (436 aa)
	abcg8	ATP-binding cassette, sub-family G (WHITE), member 8. (669 aa)
	abcg5	ATP-binding cassette, sub-family G (WHITE), member 5. (608 aa)
	VPS4B	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (437 aa)
	LOC103477848	Apolipoprotein Eb. (265 aa)
	scp2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (572 aa)
	apob	Apolipoprotein Ba. (4338 aa)
	LOC103457447	Apolipoprotein Bb, tandem duplicate 2. (3356 aa)
	ENSPREP00000010257	Uncharacterized protein. (434 aa)
	ENSPREP00000010344	Vitellogenin domain-containing protein. (759 aa)
	LOC103474828	Apolipoprotein A-Ib. (263 aa)
	LOC103473017	Apolipoprotein Ea. (251 aa)
	star	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (286 aa)
	NPC1L1	NPC1 like intracellular cholesterol transporter 1. (1341 aa)
	npc2	Niemann-Pick disease, type C2. (158 aa)
	stard3	StAR-related lipid transfer (START) domain containing 3. (477 aa)
	LOC103466506	Synaptotagmin VIIa. (606 aa)
	LOC103460228	ATP-binding cassette, sub-family D (ALD), member 1. (785 aa)
	podn	Podocan. (587 aa)
	scarb1	Scavenger receptor class B, member 1; Belongs to the CD36 family. (490 aa)
	ENSPREP00000021963	LIM zinc-binding domain-containing protein. (129 aa)
	relch	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1189 aa)
	npc1	Niemann-Pick disease, type C1. (1277 aa)
	LOC103472050	Low density lipoprotein receptor adaptor protein 1a. (310 aa)
	arv1	ARV1 homolog, fatty acid homeostasis modulator. (240 aa)
	stard3nl	STARD3 N-terminal like. (230 aa)
	lima1	LIM domain and actin binding 1a. (617 aa)
	LOC103463808	Uncharacterized protein; Belongs to the AAA ATPase family. (411 aa)
	ENSPREP00000031515	LIM zinc-binding domain-containing protein. (211 aa)
	ENSPREP00000031527	Uncharacterized protein. (1802 aa)
	LOC103473964	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (506 aa)
	stard5	StAR-related lipid transfer (START) domain containing 5. (211 aa)
	LOC103462425	Synaptotagmin VIIb. (468 aa)
	abcg4	ATP-binding cassette, sub-family G (WHITE), member 4a. (649 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000010257	ENSPREP00000010344	ENSPREP00000010257	ENSPREP00000010344	Uncharacterized protein.	Vitellogenin domain-containing protein.	0.739
ENSPREP00000010257	LOC103472050	ENSPREP00000010257	ENSPREP00000025442	Uncharacterized protein.	Low density lipoprotein receptor adaptor protein 1a.	0.539
ENSPREP00000010257	LOC103473017	ENSPREP00000010257	ENSPREP00000013094	Uncharacterized protein.	Apolipoprotein Ea.	0.674
ENSPREP00000010257	LOC103474828	ENSPREP00000010257	ENSPREP00000010904	Uncharacterized protein.	Apolipoprotein A-Ib.	0.801
ENSPREP00000010257	LOC103477848	ENSPREP00000010257	ENSPREP00000006664	Uncharacterized protein.	Apolipoprotein Eb.	0.757
ENSPREP00000010257	cetp	ENSPREP00000010257	ENSPREP00000003448	Uncharacterized protein.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.675
ENSPREP00000010257	ldlrap1	ENSPREP00000010257	ENSPREP00000004477	Uncharacterized protein.	Low density lipoprotein receptor adaptor protein 1b.	0.619
ENSPREP00000010257	npc2	ENSPREP00000010257	ENSPREP00000014847	Uncharacterized protein.	Niemann-Pick disease, type C2.	0.562
ENSPREP00000010257	scarb1	ENSPREP00000010257	ENSPREP00000021860	Uncharacterized protein.	Scavenger receptor class B, member 1; Belongs to the CD36 family.	0.727
ENSPREP00000010344	ENSPREP00000010257	ENSPREP00000010344	ENSPREP00000010257	Vitellogenin domain-containing protein.	Uncharacterized protein.	0.739
ENSPREP00000010344	LOC103472050	ENSPREP00000010344	ENSPREP00000025442	Vitellogenin domain-containing protein.	Low density lipoprotein receptor adaptor protein 1a.	0.539
ENSPREP00000010344	LOC103473017	ENSPREP00000010344	ENSPREP00000013094	Vitellogenin domain-containing protein.	Apolipoprotein Ea.	0.674
ENSPREP00000010344	LOC103474828	ENSPREP00000010344	ENSPREP00000010904	Vitellogenin domain-containing protein.	Apolipoprotein A-Ib.	0.801
ENSPREP00000010344	LOC103477848	ENSPREP00000010344	ENSPREP00000006664	Vitellogenin domain-containing protein.	Apolipoprotein Eb.	0.757
ENSPREP00000010344	cetp	ENSPREP00000010344	ENSPREP00000003448	Vitellogenin domain-containing protein.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.675
ENSPREP00000010344	ldlrap1	ENSPREP00000010344	ENSPREP00000004477	Vitellogenin domain-containing protein.	Low density lipoprotein receptor adaptor protein 1b.	0.619
ENSPREP00000010344	npc2	ENSPREP00000010344	ENSPREP00000014847	Vitellogenin domain-containing protein.	Niemann-Pick disease, type C2.	0.562
ENSPREP00000010344	scarb1	ENSPREP00000010344	ENSPREP00000021860	Vitellogenin domain-containing protein.	Scavenger receptor class B, member 1; Belongs to the CD36 family.	0.727
LOC103457447	LOC103472050	ENSPREP00000009874	ENSPREP00000025442	Apolipoprotein Bb, tandem duplicate 2.	Low density lipoprotein receptor adaptor protein 1a.	0.539
LOC103457447	LOC103473017	ENSPREP00000009874	ENSPREP00000013094	Apolipoprotein Bb, tandem duplicate 2.	Apolipoprotein Ea.	0.674