(42 nodes) Embryonic limb morphogenesis network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103476180	Homeobox protein engrailed-like. (284 aa)
	wdr19	WD repeat domain 19. (1343 aa)
	sp9	Sp9 transcription factor. (439 aa)
	map3k20	Uncharacterized protein. (796 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	msx1	Muscle segment homeobox 1a. (281 aa)
	LOC103470367	Uncharacterized protein. (539 aa)
	LOC103462291	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	LOC103478554	Sp8 transcription factor b. (454 aa)
	Bcl2l11	Uncharacterized protein. (202 aa)
	lef1	Lymphoid enhancer-binding factor 1. (422 aa)
	ENSPREP00000004603	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (62 aa)
	Fras1	Uncharacterized protein. (288 aa)
	frem3	Fras1 related extracellular matrix 3. (3118 aa)
	wdpcp	WD repeat containing planar cell polarity effector. (512 aa)
	sall4	Spalt-like transcription factor 4. (1082 aa)
	rpgrip1l	RPGRIP1 like. (1044 aa)
	LOC103467376	Homeobox C10a. (340 aa)
	GREM1	Gremlin. (182 aa)
	ENSPREP00000029734	Uncharacterized protein. (99 aa)
	LOC103474475	Uncharacterized protein. (342 aa)
	ift140	Intraflagellar transport 140 homolog (Chlamydomonas). (1435 aa)
	SMAD4	Mothers against decapentaplegic homolog. (439 aa)
	ift52	Intraflagellar transport 52 homolog (Chlamydomonas). (404 aa)
	mks1	MKS transition zone complex subunit 1. (540 aa)
	ENSPREP00000022877	Uncharacterized protein. (62 aa)
	tbx4	T-box transcription factor 4. (549 aa)
	LOC103482469	Homeobox protein engrailed-like. (283 aa)
	LOC103461142	F-box and WD repeat domain containing 4. (264 aa)
	LOC103477474	Mothers against decapentaplegic homolog. (534 aa)
	LOC103469565	T-box transcription factor 3b. (491 aa)
	Alx3	Uncharacterized protein. (140 aa)
	tbx3	T-box transcription factor 3a. (708 aa)
	LOC103476799	Dickkopf WNT signaling pathway inhibitor 1a. (242 aa)
	LOC103473773	Mothers against decapentaplegic homolog. (503 aa)
	LOC103479332	Protein kinase domain-containing protein. (674 aa)
	LOC103474980	FRAS1 related extracellular matrix 2b. (3114 aa)
	ENSPREP00000018426	Uncharacterized protein. (108 aa)
	BAX	BCL2 associated X, apoptosis regulator. (191 aa)
	ENSPREP00000012944	Uncharacterized protein. (139 aa)
	ENSPREP00000012925	Uncharacterized protein. (113 aa)
	LOC103462620	Uncharacterized protein. (254 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAX	Bcl2l11	ENSPREP00000013021	ENSPREP00000002893	BCL2 associated X, apoptosis regulator.	Uncharacterized protein.	0.990
Bcl2l11	BAX	ENSPREP00000002893	ENSPREP00000013021	Uncharacterized protein.	BCL2 associated X, apoptosis regulator.	0.990
ENSPREP00000012925	ENSPREP00000012944	ENSPREP00000012925	ENSPREP00000012944	Uncharacterized protein.	Uncharacterized protein.	0.746
ENSPREP00000012944	ENSPREP00000012925	ENSPREP00000012944	ENSPREP00000012925	Uncharacterized protein.	Uncharacterized protein.	0.746
ENSPREP00000029734	LOC103461142	ENSPREP00000029734	ENSPREP00000022584	Uncharacterized protein.	F-box and WD repeat domain containing 4.	0.921
Fras1	LOC103474980	ENSPREP00000005000	ENSPREP00000019629	Uncharacterized protein.	FRAS1 related extracellular matrix 2b.	0.965
Fras1	frem3	ENSPREP00000005000	ENSPREP00000034333	Uncharacterized protein.	Fras1 related extracellular matrix 3.	0.842
LOC103461142	ENSPREP00000029734	ENSPREP00000022584	ENSPREP00000029734	F-box and WD repeat domain containing 4.	Uncharacterized protein.	0.921
LOC103473773	LOC103477474	ENSPREP00000020499	ENSPREP00000022544	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
LOC103473773	lef1	ENSPREP00000020499	ENSPREP00000003479	Mothers against decapentaplegic homolog.	Lymphoid enhancer-binding factor 1.	0.948
LOC103474475	LOC103476799	ENSPREP00000028750	ENSPREP00000021364	Uncharacterized protein.	Dickkopf WNT signaling pathway inhibitor 1a.	0.436
LOC103474980	Fras1	ENSPREP00000019629	ENSPREP00000005000	FRAS1 related extracellular matrix 2b.	Uncharacterized protein.	0.965
LOC103476799	LOC103474475	ENSPREP00000021364	ENSPREP00000028750	Dickkopf WNT signaling pathway inhibitor 1a.	Uncharacterized protein.	0.436
LOC103476799	lef1	ENSPREP00000021364	ENSPREP00000003479	Dickkopf WNT signaling pathway inhibitor 1a.	Lymphoid enhancer-binding factor 1.	0.529
LOC103476799	sfrp2	ENSPREP00000021364	ENSPREP00000000067	Dickkopf WNT signaling pathway inhibitor 1a.	Secreted frizzled-related protein 2.	0.436
LOC103477474	LOC103473773	ENSPREP00000022544	ENSPREP00000020499	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
LOC103477474	lef1	ENSPREP00000022544	ENSPREP00000003479	Mothers against decapentaplegic homolog.	Lymphoid enhancer-binding factor 1.	0.948
LOC103479332	map3k20	ENSPREP00000019978	ENSPREP00000007414	Protein kinase domain-containing protein.	Uncharacterized protein.	0.902
SMAD4	lef1	ENSPREP00000027467	ENSPREP00000003479	Mothers against decapentaplegic homolog.	Lymphoid enhancer-binding factor 1.	0.505
frem3	Fras1	ENSPREP00000034333	ENSPREP00000005000	Fras1 related extracellular matrix 3.	Uncharacterized protein.	0.842