(113 nodes) Intracellular receptor signaling pathway network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RARG	Retinoic acid receptor gamma. (517 aa)
	LOC103464681	DEAD-box helicase 17; Belongs to the DEAD box helicase family. (651 aa)
	ALPK1	Alpha kinase 1. (1056 aa)
	LOC103467778	Nuclear receptor subfamily 4, group A, member 1. (562 aa)
	nr1i2	Nuclear receptor subfamily 1, group I, member 2. (355 aa)
	LOC103466861	Uncharacterized protein. (420 aa)
	LOC103477705	Uncharacterized protein. (469 aa)
	LOC103464934	Vitamin D receptor b. (425 aa)
	LOC103477707	Nuclear receptor subfamily 1, group D, member 2a. (544 aa)
	ENSPREP00000002932	Si:ch211-15b10.6. (187 aa)
	Tifa	Si:ch211-15b10.6. (191 aa)
	LOC103458082	Estrogen receptor 2b. (664 aa)
	LOC103478548	Retinoid x receptor, beta b. (412 aa)
	LOC103482193	Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (506 aa)
	LOC103462202	Uncharacterized protein. (435 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (621 aa)
	nr2c1	Nuclear receptor subfamily 2, group C, member 1. (565 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (464 aa)
	sting1	Transmembrane protein 173. (484 aa)
	LOC103471211	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (765 aa)
	Nr2f1	Nuclear receptor subfamily 2, group F, member 1a. (360 aa)
	nr2e1	Nuclear receptor subfamily 2, group E, member 1. (385 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (745 aa)
	LOC103468746	Nuclear receptor subfamily 5, group A, member 5. (501 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (474 aa)
	LOC103470500	NK3 homeobox 1. (196 aa)
	nr2f2	Nuclear receptor subfamily 2, group F, member 2. (266 aa)
	OTULIN	OTU deubiquitinase with linear linkage specificity. (399 aa)
	RXRB	Retinoid X receptor beta. (417 aa)
	trip4	Thyroid hormone receptor interactor 4. (573 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (582 aa)
	ENSPREP00000011180	Nuclear receptor subfamily 5, group A, member 2. (465 aa)
	lsm14a	LSM14A mRNA processing body assembly factor b. (463 aa)
	ppargc1b	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta. (929 aa)
	ifih1	Interferon induced with helicase C domain 1. (969 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (315 aa)
	phb	Prohibitin. (271 aa)
	LOC103479151	Nuclear receptor subfamily 2, group F, member 6a. (404 aa)
	nr4a2	Nuclear receptor subfamily 4, group A, member 2b. (601 aa)
	rora	RAR-related orphan receptor A, paralog a. (478 aa)
	ahrr	Uncharacterized protein. (682 aa)
	ESRRB	Estrogen-related receptor beta. (477 aa)
	rorb	RAR-related orphan receptor B. (479 aa)
	ppara	Peroxisome proliferator-activated receptor alpha a. (472 aa)
	LOC103467002	Nuclear receptor subfamily 1, group H, member 5. (494 aa)
	LOC103463612	RAR-related orphan receptor C a. (475 aa)
	fam120b	Family with sequence similarity 120B. (741 aa)
	LOC103466558	Nuclear receptor subfamily 2, group E, member 3. (407 aa)
	pitx2	Homeobox protein. (312 aa)
	dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58. (681 aa)
	LOC103470611	Ring finger protein 34a. (520 aa)
	LOC103463575	Uncharacterized protein. (438 aa)
	SRC	Tyrosine-protein kinase. (569 aa)
	LOC103473722	Ring finger protein 34b. (365 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (469 aa)
	lacc1	Laccase (multicopper oxidoreductase) domain containing 1. (429 aa)
	ptf1a	Pancreas associated transcription factor 1a. (267 aa)
	LOC103473114	Uncharacterized protein. (439 aa)
	ENSPREP00000017463	Uncharacterized protein. (388 aa)
	LOC103462767	Estrogen-related receptor gamma a. (557 aa)
	esrra	Estrogen-related receptor alpha. (433 aa)
	THRA	Thyroid hormone receptor alpha. (413 aa)
	LOC103469458	Nuclear receptor subfamily 1, group d, member 1. (523 aa)
	LOC103463289	Nuclear receptor subfamily 2, group F, member 6b. (406 aa)
	LOC103479274	RAR-related orphan receptor C b. (500 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (591 aa)
	nr6a1	Nuclear receptor subfamily 6, group A, member 1a. (458 aa)
	LOC103472129	Retinoic acid receptor beta. (414 aa)
	ENSPREP00000020228	Thyroid hormone receptor beta. (482 aa)
	LOC103471958	Nuclear receptor subfamily 1, group D, member 2b. (583 aa)
	LOC103465308	Innate immunity activator b. (580 aa)
	LOC103465339	Retinoic acid receptor, gamma b. (405 aa)
	LOC103465341	Nuclear receptor subfamily 1, group D, member 4b. (573 aa)
	LOC103468401	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family. (636 aa)
	pgr	Progesterone receptor. (642 aa)
	LOC103457290	Estrogen receptor 2a. (507 aa)
	LOC103473768	Uncharacterized protein. (614 aa)
	LOC103482332	Uncharacterized protein. (963 aa)
	LOC103482321	Uncharacterized protein. (947 aa)
	LOC103456526	Hepatocyte nuclear factor 4, gamma. (549 aa)
	LOC103478141	RAR-related orphan receptor C. (468 aa)
	nr2c2	Nuclear receptor subfamily 2, group C, member 2. (598 aa)
	ubr5	Ubiquitin protein ligase E3 component n-recognin 5. (2851 aa)
	LOC103462988	Uncharacterized protein. (521 aa)
	LOC103466382	LSM14A mRNA processing body assembly factor a. (480 aa)
	ube3a	Ubiquitin protein ligase E3A. (823 aa)
	LOC103477571	Nuclear receptor subfamily 2, group F, member 5. (404 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (944 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (485 aa)
	Gper1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (321 aa)
	LOC103460470	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (496 aa)
	tmf1	TATA element modulatory factor 1. (1150 aa)
	snw1	SNW domain containing 1. (536 aa)
	rwdd1	RWD domain containing 1. (240 aa)
	LOC103457805	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (301 aa)
	nr4a3	Nuclear receptor subfamily 4, group A, member 3. (587 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (636 aa)
	CLPB	ClpB homolog, mitochondrial AAA ATPase chaperonin. (682 aa)
	LOC103457594	Uncharacterized protein. (456 aa)
	LOC103480795	Uncharacterized protein. (996 aa)
	LOC103467373	Nuclear receptor subfamily 1, group D, member 4a. (585 aa)
	rara	Retinoic acid receptor, alpha a. (452 aa)
	hnf4a	Hepatocyte nuclear factor 4, alpha. (461 aa)
	LOC103475709	Androgen receptor. (757 aa)
	LOC103467856	Tyrosine-protein kinase. (542 aa)
	ar	Androgen receptor. (685 aa)
	LOC103457262	Aryl hydrocarbon receptor 1b. (810 aa)
	LOC103457584	Aryl hydrocarbon receptor 2. (750 aa)
	Rxra	Retinoid X receptor, alpha a. (410 aa)
	LOC103457879	Uncharacterized protein. (801 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (401 aa)
	LOC103467293	Innate immunity activator a. (568 aa)
	ENSPREP00000034277	Hepatic nuclear factor 4, beta. (375 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALPK1	ENSPREP00000002932	ENSPREP00000000841	ENSPREP00000002932	Alpha kinase 1.	Si:ch211-15b10.6.	0.784
ALPK1	Tifa	ENSPREP00000000841	ENSPREP00000002948	Alpha kinase 1.	Si:ch211-15b10.6.	0.784
CLPB	phb	ENSPREP00000028464	ENSPREP00000012361	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Prohibitin.	0.432
DDX5	LOC103457290	ENSPREP00000027962	ENSPREP00000023210	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor 2a.	0.581
DDX5	LOC103458082	ENSPREP00000027962	ENSPREP00000003460	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor 2b.	0.581
DDX5	LOC103468401	ENSPREP00000027962	ENSPREP00000022845	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family.	0.901
DDX5	esr1	ENSPREP00000027962	ENSPREP00000006015	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.581
ENSPREP00000002932	ALPK1	ENSPREP00000002932	ENSPREP00000000841	Si:ch211-15b10.6.	Alpha kinase 1.	0.784
ENSPREP00000011180	LOC103457290	ENSPREP00000011180	ENSPREP00000023210	Nuclear receptor subfamily 5, group A, member 2.	Estrogen receptor 2a.	0.510
ENSPREP00000011180	LOC103458082	ENSPREP00000011180	ENSPREP00000003460	Nuclear receptor subfamily 5, group A, member 2.	Estrogen receptor 2b.	0.510
ENSPREP00000011180	LOC103464934	ENSPREP00000011180	ENSPREP00000002531	Nuclear receptor subfamily 5, group A, member 2.	Vitamin D receptor b.	0.422
ENSPREP00000011180	LOC103466861	ENSPREP00000011180	ENSPREP00000002137	Nuclear receptor subfamily 5, group A, member 2.	Uncharacterized protein.	0.422
ENSPREP00000011180	LOC103467002	ENSPREP00000011180	ENSPREP00000014015	Nuclear receptor subfamily 5, group A, member 2.	Nuclear receptor subfamily 1, group H, member 5.	0.463
ENSPREP00000011180	esr1	ENSPREP00000011180	ENSPREP00000006015	Nuclear receptor subfamily 5, group A, member 2.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.531
ENSPREP00000011180	nr1h3	ENSPREP00000011180	ENSPREP00000006124	Nuclear receptor subfamily 5, group A, member 2.	Nuclear receptor subfamily 1, group H, member 3.	0.463
ENSPREP00000011180	nr1h4	ENSPREP00000011180	ENSPREP00000026448	Nuclear receptor subfamily 5, group A, member 2.	Nuclear receptor subfamily 1, group H, member 4.	0.463
ENSPREP00000011180	nr1i2	ENSPREP00000011180	ENSPREP00000000959	Nuclear receptor subfamily 5, group A, member 2.	Nuclear receptor subfamily 1, group I, member 2.	0.520
ENSPREP00000017463	LOC103463575	ENSPREP00000017463	ENSPREP00000016159	Uncharacterized protein.	Uncharacterized protein.	0.549
ENSPREP00000017463	LOC103465341	ENSPREP00000017463	ENSPREP00000022194	Uncharacterized protein.	Nuclear receptor subfamily 1, group D, member 4b.	0.485
ENSPREP00000017463	LOC103471958	ENSPREP00000017463	ENSPREP00000020256	Uncharacterized protein.	Nuclear receptor subfamily 1, group D, member 2b.	0.485