(64 nodes) Cortical actin cytoskeleton network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPREP00000018142	Uncharacterized protein. (49 aa)
	LOC103468315	PDZ domain-containing protein. (933 aa)
	dbn1	Drebrin 1. (528 aa)
	ENSPREP00000019143	ADF-H domain-containing protein. (131 aa)
	ENSPREP00000019223	Uncharacterized protein. (109 aa)
	flot1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
	LOC103475822	Spectrin beta chain; Belongs to the spectrin family. (2375 aa)
	golgb1	Golgin B1. (2332 aa)
	LOC103459100	Hematopoietic cell-specific Lyn substrate 1. (459 aa)
	LOC103476978	Vinculin a. (1135 aa)
	ACTN4	Actinin alpha 4. (898 aa)
	ENSPREP00000029556	PDZ domain-containing protein. (123 aa)
	LOC103473938	Shroom family member 3. (1598 aa)
	Llgl1	LLGL scribble cell polarity complex component 1. (308 aa)
	WDR1	WD repeat domain 1. (605 aa)
	LOC103481154	MARVEL domain-containing protein. (288 aa)
	LOC103481123	Uncharacterized protein. (280 aa)
	sptbn4	Spectrin, beta, non-erythrocytic 4b. (1946 aa)
	actn1	Actinin, alpha 1. (912 aa)
	shroom2	Uncharacterized protein. (1621 aa)
	pjvk	Pejvakin. (356 aa)
	cttn	Cortactin. (465 aa)
	LOC103461155	Neurofibromin 2a (merlin). (394 aa)
	LOC103456545	Uncharacterized protein. (1330 aa)
	myrip	Myosin VIIA and Rab interacting protein. (1039 aa)
	LOC103461030	Uncharacterized protein. (791 aa)
	LOC103473180	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	LOC103479813	Si:ch211-106h4.9. (986 aa)
	ENSPREP00000020216	PDZ domain-containing protein. (88 aa)
	plekhh1	Pleckstrin homology domain containing, family H (with MyTH4 domain) member 1. (1425 aa)
	anln	Anillin, actin binding protein. (1138 aa)
	LOC103458402	Spectrin beta chain; Belongs to the spectrin family. (2088 aa)
	cotl1	Coactosin-like F-actin binding protein 1. (150 aa)
	LOC103469311	Zgc:77748. (283 aa)
	LOC103469310	Uncharacterized protein. (287 aa)
	LOC103479524	Si:dkeyp-66d1.7. (293 aa)
	llgl2	LLGL scribble cell polarity complex component 2. (1006 aa)
	ENSPREP00000002127	RabBD domain-containing protein. (192 aa)
	ppp1r9a	Protein phosphatase 1, regulatory subunit 9A. (1113 aa)
	LOC103466362	Si:dkey-30c15.10. (733 aa)
	actn3	Actinin alpha 3b. (897 aa)
	vcl	Vinculin b. (1100 aa)
	Kncn	Uncharacterized protein. (93 aa)
	LOC103470450	Si:dkey-40c11.2. (812 aa)
	LOC103458430	Protein phosphatase 1 regulatory subunit 9A-like A. (1444 aa)
	ENSPREP00000007673	ASD1 domain-containing protein. (1033 aa)
	LOC103471729	Spectrin beta chain; Belongs to the spectrin family. (2335 aa)
	sptan1	Spectrin alpha, non-erythrocytic 1. (2568 aa)
	dbnl	Drebrin-like b. (479 aa)
	LOC103472976	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (350 aa)
	LOC103480351	Uncharacterized protein. (282 aa)
	nf2	Neurofibromin 2b (merlin). (615 aa)
	cald1	Uncharacterized protein. (496 aa)
	LOC103481654	Protein phosphatase 1, regulatory subunit 9Bb. (813 aa)
	LOC103476717	Actinin, alpha 2b. (894 aa)
	shroom4	ASD2 domain-containing protein. (1670 aa)
	plekhh2	Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2. (1417 aa)
	LOC103481063	Melanophilin a. (571 aa)
	LOC103478362	Cordon-bleu WH2 repeat protein. (1443 aa)
	Cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (142 aa)
	LOC103476183	PH domain-containing protein. (1567 aa)
	ENSPREP00000018081	PH_9 domain-containing protein. (637 aa)
	ENSPREP00000018112	Uncharacterized protein. (369 aa)
	ENSPREP00000018131	Uncharacterized protein. (258 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN4	ENSPREP00000018081	ENSPREP00000030255	ENSPREP00000018081	Actinin alpha 4.	PH_9 domain-containing protein.	0.895
ACTN4	ENSPREP00000018112	ENSPREP00000030255	ENSPREP00000018112	Actinin alpha 4.	Uncharacterized protein.	0.841
ACTN4	LOC103476978	ENSPREP00000030255	ENSPREP00000032212	Actinin alpha 4.	Vinculin a.	0.961
ACTN4	actn1	ENSPREP00000030255	ENSPREP00000027161	Actinin alpha 4.	Actinin, alpha 1.	0.900
ACTN4	vcl	ENSPREP00000030255	ENSPREP00000004437	Actinin alpha 4.	Vinculin b.	0.961
Cldn5	LOC103473180	ENSPREP00000017247	ENSPREP00000020548	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.658
ENSPREP00000018081	ACTN4	ENSPREP00000018081	ENSPREP00000030255	PH_9 domain-containing protein.	Actinin alpha 4.	0.895
ENSPREP00000018081	ENSPREP00000018112	ENSPREP00000018081	ENSPREP00000018112	PH_9 domain-containing protein.	Uncharacterized protein.	0.951
ENSPREP00000018081	ENSPREP00000018131	ENSPREP00000018081	ENSPREP00000018131	PH_9 domain-containing protein.	Uncharacterized protein.	0.900
ENSPREP00000018081	LOC103476717	ENSPREP00000018081	ENSPREP00000014912	PH_9 domain-containing protein.	Actinin, alpha 2b.	0.889
ENSPREP00000018081	actn1	ENSPREP00000018081	ENSPREP00000027161	PH_9 domain-containing protein.	Actinin, alpha 1.	0.880
ENSPREP00000018081	actn3	ENSPREP00000018081	ENSPREP00000004223	PH_9 domain-containing protein.	Actinin alpha 3b.	0.891
ENSPREP00000018081	sptan1	ENSPREP00000018081	ENSPREP00000010216	PH_9 domain-containing protein.	Spectrin alpha, non-erythrocytic 1.	0.862
ENSPREP00000018112	ACTN4	ENSPREP00000018112	ENSPREP00000030255	Uncharacterized protein.	Actinin alpha 4.	0.841
ENSPREP00000018112	ENSPREP00000018081	ENSPREP00000018112	ENSPREP00000018081	Uncharacterized protein.	PH_9 domain-containing protein.	0.951
ENSPREP00000018112	ENSPREP00000018131	ENSPREP00000018112	ENSPREP00000018131	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSPREP00000018112	sptan1	ENSPREP00000018112	ENSPREP00000010216	Uncharacterized protein.	Spectrin alpha, non-erythrocytic 1.	0.862
ENSPREP00000018131	ENSPREP00000018081	ENSPREP00000018131	ENSPREP00000018081	Uncharacterized protein.	PH_9 domain-containing protein.	0.900
ENSPREP00000018131	ENSPREP00000018112	ENSPREP00000018131	ENSPREP00000018112	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSPREP00000018131	LOC103476183	ENSPREP00000018131	ENSPREP00000017361	Uncharacterized protein.	PH domain-containing protein.	0.876