(8 nodes) HOPS complex network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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protein homology

Your Input:
	vps41	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (846 aa)
	stx17	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (304 aa)
	hook2	Hook microtubule-tethering protein 2. (666 aa)
	vps39	VPS39 subunit of HOPS complex. (876 aa)
	vps33a	VPS33A core subunit of CORVET and HOPS complexes; Belongs to the STXBP/unc-18/SEC1 family. (600 aa)
	vps16	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (834 aa)
	vps18	VPS18 core subunit of CORVET and HOPS complexes. (982 aa)
	vps11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (928 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
stx17	vps11	ENSPREP00000027681	ENSPREP00000020294	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	0.804
stx17	vps16	ENSPREP00000027681	ENSPREP00000016077	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	0.870
stx17	vps18	ENSPREP00000027681	ENSPREP00000020126	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	VPS18 core subunit of CORVET and HOPS complexes.	0.796
stx17	vps33a	ENSPREP00000027681	ENSPREP00000012520	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	VPS33A core subunit of CORVET and HOPS complexes; Belongs to the STXBP/unc-18/SEC1 family.	0.741
stx17	vps39	ENSPREP00000027681	ENSPREP00000012346	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	VPS39 subunit of HOPS complex.	0.970
stx17	vps41	ENSPREP00000027681	ENSPREP00000009649	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.	0.956
vps11	stx17	ENSPREP00000020294	ENSPREP00000027681	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	0.804
vps11	vps16	ENSPREP00000020294	ENSPREP00000016077	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	0.999
vps11	vps18	ENSPREP00000020294	ENSPREP00000020126	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	VPS18 core subunit of CORVET and HOPS complexes.	0.999
vps11	vps33a	ENSPREP00000020294	ENSPREP00000012520	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	VPS33A core subunit of CORVET and HOPS complexes; Belongs to the STXBP/unc-18/SEC1 family.	0.997
vps11	vps39	ENSPREP00000020294	ENSPREP00000012346	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	VPS39 subunit of HOPS complex.	0.999
vps11	vps41	ENSPREP00000020294	ENSPREP00000009649	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.	0.999
vps16	stx17	ENSPREP00000016077	ENSPREP00000027681	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	0.870
vps16	vps11	ENSPREP00000016077	ENSPREP00000020294	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	0.999
vps16	vps18	ENSPREP00000016077	ENSPREP00000020126	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	VPS18 core subunit of CORVET and HOPS complexes.	0.999
vps16	vps33a	ENSPREP00000016077	ENSPREP00000012520	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	VPS33A core subunit of CORVET and HOPS complexes; Belongs to the STXBP/unc-18/SEC1 family.	0.999
vps16	vps39	ENSPREP00000016077	ENSPREP00000012346	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	VPS39 subunit of HOPS complex.	0.999
vps16	vps41	ENSPREP00000016077	ENSPREP00000009649	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.	0.999
vps18	stx17	ENSPREP00000020126	ENSPREP00000027681	VPS18 core subunit of CORVET and HOPS complexes.	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	0.796
vps18	vps11	ENSPREP00000020126	ENSPREP00000020294	VPS18 core subunit of CORVET and HOPS complexes.	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	0.999