(110 nodes) Hindbrain development network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPREP00000013704	Uncharacterized protein. (155 aa)
	Mib1	Mindbomb E3 ubiquitin protein ligase 1. (994 aa)
	LOC103469771	Zinc finger protein 703. (579 aa)
	LOC103476847	Paired box 2a. (322 aa)
	clp1	Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (441 aa)
	abl2	Tyrosine-protein kinase. (1187 aa)
	wdr73	WD repeat domain 73. (375 aa)
	efnb2	Ephrin-B2a; Belongs to the ephrin family. (313 aa)
	agtpbp1	ATP/GTP binding protein 1. (1264 aa)
	ENSPREP00000028461	Achaete-scute family bHLH transcription factor 1b. (177 aa)
	phox2a	Paired like homeobox 2A. (301 aa)
	gsx2	GS homeobox 2. (239 aa)
	trnp1	Si:ch211-160f23.7. (200 aa)
	LOC103476521	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC103470891	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	LOC103470892	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
	rpgrip1l	RPGRIP1 like. (1044 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
	chmp1a	Charged multivesicular body protein 1A. (198 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	whrn	Whirlin a. (828 aa)
	SNX14	Sorting nexin 14. (1016 aa)
	rnf152	Ring finger protein 152. (177 aa)
	cep55	Centrosomal protein 55 like. (500 aa)
	LOC103475806	Activating transcription factor 5a. (505 aa)
	ttll1	Tubulin tyrosine ligase-like family, member 1. (424 aa)
	ENSPREP00000025224	PlsC domain-containing protein. (270 aa)
	ENSPREP00000025214	Paired domain-containing protein. (156 aa)
	LOC103469622	Whirlin b. (978 aa)
	sez6l2	Seizure related 6 homolog (mouse)-like 2. (875 aa)
	LOC103471390	Kelch-like family member 4. (729 aa)
	ENSPREP00000024223	Uncharacterized protein. (147 aa)
	LOC103480607	Cytochrome P450, family 26, subfamily b, polypeptide 1; Belongs to the cytochrome P450 family. (512 aa)
	bmp2	Bone morphogenetic protein 2b. (419 aa)
	ENSPREP00000023825	SH2 domain-containing protein. (93 aa)
	hspa5	Heat shock protein 5; Belongs to the heat shock protein 70 family. (652 aa)
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (619 aa)
	ENSPREP00000023272	Uncharacterized protein. (267 aa)
	LOC103461154	RNA binding motif protein 7. (262 aa)
	LOC103457903	Homeobox domain-containing protein. (307 aa)
	LOC103482469	Homeobox protein engrailed-like. (283 aa)
	ENSPREP00000022685	Abelson helper integration site 1. (907 aa)
	lhx1	LIM homeobox 1a. (374 aa)
	ENSPREP00000022294	Bmi1 polycomb ring finger oncogene 1a. (345 aa)
	pax8	Paired box 8. (495 aa)
	LOC103474297	Activating transcription factor 5b. (470 aa)
	abl1	Tyrosine-protein kinase. (1124 aa)
	LOC103473186	Seizure related 6 homolog (mouse)-like. (620 aa)
	sema3d	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; Belongs to the semaphorin family. (794 aa)
	pax6	Paired box 6b. (431 aa)
	prkci	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
	gbx2	Gastrulation brain homeobox 2. (339 aa)
	LOC103479267	Uncharacterized protein. (1084 aa)
	med12	Mediator complex subunit 12. (2052 aa)
	cdk5r1	Cyclin-dependent kinase 5 activator. (450 aa)
	ENSPREP00000018776	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (824 aa)
	mecp2	Methyl CpG binding protein 2. (982 aa)
	LOC103457687	Si:ch73-21k16.5; Belongs to the GPAT/DAPAT family. (676 aa)
	Neurog1	Neurogenin 1. (202 aa)
	ENSPREP00000017474	Uncharacterized protein. (93 aa)
	LOC103468291	Cyclin-dependent kinase 5 activator. (334 aa)
	ptf1a	Pancreas associated transcription factor 1a. (267 aa)
	rest	RE1-silencing transcription factor. (902 aa)
	otx2	Orthodenticle homeobox 2b. (290 aa)
	epha4	Eph receptor A4, like. (979 aa)
	LOC103474919	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (762 aa)
	LOC103464644	Si:dkey-49n23.1; Belongs to the semaphorin family. (731 aa)
	MAFB	MAF bZIP transcription factor B. (410 aa)
	LOC103460864	Uncharacterized protein; Belongs to the MAGUK family. (538 aa)
	crk	CRK proto-oncogene, adaptor protein. (315 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (427 aa)
	LOC103473007	Cyclin-dependent kinase 5 activator. (321 aa)
	mpp5	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (650 aa)
	LOC103480354	Vang-like protein. (525 aa)
	LOC103476180	Homeobox protein engrailed-like. (284 aa)
	LOC103462620	Uncharacterized protein. (254 aa)
	LOC103474848	Coenzyme Q8B. (649 aa)
	cdk5	Cyclin-dependent kinase 5. (262 aa)
	LOC103473609	POU domain protein. (513 aa)
	ENSPREP00000011364	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1074 aa)
	ttc21b	Tetratricopeptide repeat domain 21B. (1317 aa)
	klhl5	Kelch-like family member 5. (783 aa)
	LOC103465784	Uncharacterized protein. (393 aa)
	ENSPREP00000010317	Uncharacterized protein. (390 aa)
	phox2b	Paired like homeobox 2Bb. (285 aa)
	ascl1	Achaete-scute family bHLH transcription factor 1a. (200 aa)
	pax5	Paired box 5. (396 aa)
	crkl	V-crk avian sarcoma virus CT10 oncogene homolog-like. (310 aa)
	arl13b	ADP-ribosylation factor-like 13b. (405 aa)
	pdss2	Prenyl (decaprenyl) diphosphate synthase, subunit 2; Belongs to the FPP/GGPP synthase family. (379 aa)
	LOC103471204	Ubiquinol-cytochrome c reductase, complex III subunit VII. (82 aa)
	LOC103461327	Uncharacterized protein. (406 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (865 aa)
	Srrm4	Serine/arginine repetitive matrix 4. (417 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (811 aa)
	naglu	N-acetylglucosaminidase, alpha. (796 aa)
	ENSPREP00000005246	Protein kinase domain-containing protein. (250 aa)
	rfng	Beta-1,3-N-acetylglucosaminyltransferase. (387 aa)
	Kndc1	Uncharacterized protein. (592 aa)
	cep290	Centrosomal protein 290. (2041 aa)
	LOC103482193	Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (506 aa)
	egr2	Early growth response protein 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4; Belongs to the EGR C2H2-type zinc-finger protein family. (444 aa)
	lef1	Lymphoid enhancer-binding factor 1. (422 aa)
	ENSPREP00000003163	Paired box 4. (287 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
	LOC103481447	Paired box 2b. (392 aa)
	ENSPREP00000001616	LIM zinc-binding domain-containing protein. (57 aa)
	sez6	Seizure related 6 homolog a. (1010 aa)
	NCSTN	Nicastrin. (699 aa)
	VANGL2	VANGL planar cell polarity protein 2. (691 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH2	abl1	ENSPREP00000007079	ENSPREP00000021197	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Tyrosine-protein kinase.	0.414
CDH2	abl2	ENSPREP00000007079	ENSPREP00000026823	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Tyrosine-protein kinase.	0.414
ENSPREP00000001616	ENSPREP00000025214	ENSPREP00000001616	ENSPREP00000025214	LIM zinc-binding domain-containing protein.	Paired domain-containing protein.	0.416
ENSPREP00000003163	Neurog1	ENSPREP00000003163	ENSPREP00000017486	Paired box 4.	Neurogenin 1.	0.423
ENSPREP00000005246	efnb2	ENSPREP00000005246	ENSPREP00000028109	Protein kinase domain-containing protein.	Ephrin-B2a; Belongs to the ephrin family.	0.574
ENSPREP00000010317	ENSPREP00000022685	ENSPREP00000010317	ENSPREP00000022685	Uncharacterized protein.	Abelson helper integration site 1.	0.498
ENSPREP00000010317	arl13b	ENSPREP00000010317	ENSPREP00000009259	Uncharacterized protein.	ADP-ribosylation factor-like 13b.	0.460
ENSPREP00000010317	rpgrip1l	ENSPREP00000010317	ENSPREP00000030453	Uncharacterized protein.	RPGRIP1 like.	0.528
ENSPREP00000011364	cep55	ENSPREP00000011364	ENSPREP00000033526	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Centrosomal protein 55 like.	0.781
ENSPREP00000013704	LOC103460864	ENSPREP00000013704	ENSPREP00000013760	Uncharacterized protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.854
ENSPREP00000013704	LOC103480354	ENSPREP00000013704	ENSPREP00000012627	Uncharacterized protein.	Vang-like protein.	0.455
ENSPREP00000013704	VANGL2	ENSPREP00000013704	ENSPREP00000001301	Uncharacterized protein.	VANGL planar cell polarity protein 2.	0.455
ENSPREP00000018776	NCSTN	ENSPREP00000018776	ENSPREP00000001339	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Nicastrin.	0.693
ENSPREP00000018776	abl1	ENSPREP00000018776	ENSPREP00000021197	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Tyrosine-protein kinase.	0.414
ENSPREP00000018776	abl2	ENSPREP00000018776	ENSPREP00000026823	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Tyrosine-protein kinase.	0.414
ENSPREP00000022294	wdr73	ENSPREP00000022294	ENSPREP00000027306	Bmi1 polycomb ring finger oncogene 1a.	WD repeat domain 73.	0.419
ENSPREP00000022685	ENSPREP00000010317	ENSPREP00000022685	ENSPREP00000010317	Abelson helper integration site 1.	Uncharacterized protein.	0.498
ENSPREP00000022685	arl13b	ENSPREP00000022685	ENSPREP00000009259	Abelson helper integration site 1.	ADP-ribosylation factor-like 13b.	0.550
ENSPREP00000022685	cep290	ENSPREP00000022685	ENSPREP00000004440	Abelson helper integration site 1.	Centrosomal protein 290.	0.498
ENSPREP00000022685	rpgrip1l	ENSPREP00000022685	ENSPREP00000030453	Abelson helper integration site 1.	RPGRIP1 like.	0.630