(28 nodes) Endocrine pancreas development network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103458622	Insulinoma-associated 1b. (414 aa)
	LOC103462295	Zgc:153993. (263 aa)
	ENSPREP00000003163	Paired box 4. (287 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (811 aa)
	neurod1	Neurogenic differentiation factor. (353 aa)
	LOC103459284	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1072 aa)
	LOC103465784	Uncharacterized protein. (393 aa)
	mnx1	Motor neuron and pancreas homeobox 1. (320 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (427 aa)
	CDKAL1	CDK5 regulatory subunit associated protein 1 like 1. (546 aa)
	nkx6-2	NK6 homeobox 2. (281 aa)
	ENSPREP00000018401	NK6 homeobox 1. (257 aa)
	LOC103470081	Hcy-binding domain-containing protein. (435 aa)
	LOC103470080	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (397 aa)
	rfx3	Regulatory factor X, 3 (influences HLA class II expression). (760 aa)
	pax6	Paired box 6b. (431 aa)
	arx	Aristaless related homeobox a. (469 aa)
	LOC103478148	Interleukin 6 receptor. (603 aa)
	LOC103476384	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (79 aa)
	rfx6	Regulatory factor X, 6. (831 aa)
	LOC103467447	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	LOC103473309	Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism. (397 aa)
	ENSPREP00000028461	Achaete-scute family bHLH transcription factor 1b. (177 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (255 aa)
	Fitm2	Fat storage inducing transmembrane protein 2. (250 aa)
	ENSPREP00000030771	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (65 aa)
	LOC103458615	NK2 homeobox 2a. (335 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000003163	pdx1	ENSPREP00000003163	ENSPREP00000028858	Paired box 4.	Pancreatic and duodenal homeobox 1.	0.467
ENSPREP00000018401	ENSPREP00000030771	ENSPREP00000018401	ENSPREP00000030771	NK6 homeobox 1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.562
ENSPREP00000018401	LOC103458615	ENSPREP00000018401	ENSPREP00000001270	NK6 homeobox 1.	NK2 homeobox 2a.	0.438
ENSPREP00000018401	LOC103476384	ENSPREP00000018401	ENSPREP00000025882	NK6 homeobox 1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.561
ENSPREP00000018401	neurod1	ENSPREP00000018401	ENSPREP00000006308	NK6 homeobox 1.	Neurogenic differentiation factor.	0.483
ENSPREP00000018401	pdx1	ENSPREP00000018401	ENSPREP00000028858	NK6 homeobox 1.	Pancreatic and duodenal homeobox 1.	0.445
ENSPREP00000018401	shh	ENSPREP00000018401	ENSPREP00000013208	NK6 homeobox 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.415
ENSPREP00000028461	LOC103458615	ENSPREP00000028461	ENSPREP00000001270	Achaete-scute family bHLH transcription factor 1b.	NK2 homeobox 2a.	0.421
ENSPREP00000030771	ENSPREP00000018401	ENSPREP00000030771	ENSPREP00000018401	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	NK6 homeobox 1.	0.562
ENSPREP00000030771	LOC103458615	ENSPREP00000030771	ENSPREP00000001270	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	NK2 homeobox 2a.	0.513
ENSPREP00000030771	pdx1	ENSPREP00000030771	ENSPREP00000028858	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Pancreatic and duodenal homeobox 1.	0.633
ENSPREP00000030771	rfx6	ENSPREP00000030771	ENSPREP00000026416	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Regulatory factor X, 6.	0.513
LOC103458615	ENSPREP00000018401	ENSPREP00000001270	ENSPREP00000018401	NK2 homeobox 2a.	NK6 homeobox 1.	0.438
LOC103458615	ENSPREP00000028461	ENSPREP00000001270	ENSPREP00000028461	NK2 homeobox 2a.	Achaete-scute family bHLH transcription factor 1b.	0.421
LOC103458615	ENSPREP00000030771	ENSPREP00000001270	ENSPREP00000030771	NK2 homeobox 2a.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.513
LOC103458615	LOC103476384	ENSPREP00000001270	ENSPREP00000025882	NK2 homeobox 2a.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.513
LOC103458615	neurod1	ENSPREP00000001270	ENSPREP00000006308	NK2 homeobox 2a.	Neurogenic differentiation factor.	0.577
LOC103458615	nkx6-2	ENSPREP00000001270	ENSPREP00000016267	NK2 homeobox 2a.	NK6 homeobox 2.	0.438
LOC103458615	shh	ENSPREP00000001270	ENSPREP00000013208	NK2 homeobox 2a.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.511
LOC103458622	neurod1	ENSPREP00000001659	ENSPREP00000006308	Insulinoma-associated 1b.	Neurogenic differentiation factor.	0.479