(44 nodes) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cul1	Cullin 1b; Belongs to the cullin family. (776 aa)
	fbxo9	F-box protein 9. (421 aa)
	cul4a	Cullin 4A; Belongs to the cullin family. (591 aa)
	ENSPREP00000029734	Uncharacterized protein. (99 aa)
	fbxl5	F-box and leucine-rich repeat protein 5. (697 aa)
	fbxo31	F-box protein 31. (585 aa)
	LOC103465417	Zgc:175088. (191 aa)
	rbx1	Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
	fbxo4	F-box protein 4. (361 aa)
	fbxl13	F-box and leucine-rich repeat protein 13. (799 aa)
	ENSPREP00000023888	Uncharacterized protein. (220 aa)
	Fbxl17	F-box domain-containing protein. (354 aa)
	fbxl4	F-box and leucine-rich repeat protein 4. (613 aa)
	fbxl14	F-box and leucine-rich repeat protein 14a. (403 aa)
	fbxo39	Uncharacterized protein. (377 aa)
	LOC103461142	F-box and WD repeat domain containing 4. (264 aa)
	fbxw5	F-box and WD repeat domain containing 5. (626 aa)
	fbxl6	F-box domain-containing protein. (555 aa)
	cul4b	Cullin 4B; Belongs to the cullin family. (872 aa)
	fbxl16	F-box and leucine-rich repeat protein 16. (505 aa)
	nccrp1	Non-specific cytotoxic cell receptor protein 1. (257 aa)
	fbxl20	F-box and leucine-rich repeat protein 20. (436 aa)
	fbxl22	F-box and leucine-rich repeat protein 22. (228 aa)
	dmac2	Si:ch1073-228b5.2. (271 aa)
	ENSPREP00000011364	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1074 aa)
	cul2	Cullin 2; Belongs to the cullin family. (745 aa)
	skp2	F-box domain-containing protein. (426 aa)
	fbxl2	F-box and leucine-rich repeat protein 2. (432 aa)
	fbxo41	F-box protein 41. (833 aa)
	fbxo42	F-box protein 42. (701 aa)
	skp1	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (107 aa)
	fbxo33	F-box protein 33. (490 aa)
	fbxo48	F-box protein 48. (153 aa)
	FBXL14	F-box and leucine rich repeat protein 14. (400 aa)
	LOC103467679	Uncharacterized protein. (280 aa)
	LOC103467682	Uncharacterized protein. (292 aa)
	LOC103467948	Uncharacterized protein. (254 aa)
	LOC103467680	Uncharacterized protein. (269 aa)
	fbxo38	F-box protein 38. (1208 aa)
	fbxl7	Si:dkey-192l18.9. (493 aa)
	fbxw11	F-box and WD repeat domain containing 11a. (562 aa)
	fbxl15	F-box and leucine-rich repeat protein 15. (294 aa)
	LRRC29	Leucine rich repeat containing 29. (195 aa)
	fbxl18	F-box and leucine-rich repeat protein 18. (719 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000023888	Fbxl17	ENSPREP00000023888	ENSPREP00000023856	Uncharacterized protein.	F-box domain-containing protein.	0.900
ENSPREP00000023888	cul1	ENSPREP00000023888	ENSPREP00000016001	Uncharacterized protein.	Cullin 1b; Belongs to the cullin family.	0.958
ENSPREP00000023888	rbx1	ENSPREP00000023888	ENSPREP00000026459	Uncharacterized protein.	Ring-box 1, E3 ubiquitin protein ligase.	0.781
ENSPREP00000023888	skp1	ENSPREP00000023888	ENSPREP00000007574	Uncharacterized protein.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.951
ENSPREP00000023888	skp2	ENSPREP00000023888	ENSPREP00000008789	Uncharacterized protein.	F-box domain-containing protein.	0.571
ENSPREP00000029734	LOC103461142	ENSPREP00000029734	ENSPREP00000022584	Uncharacterized protein.	F-box and WD repeat domain containing 4.	0.921
ENSPREP00000029734	cul1	ENSPREP00000029734	ENSPREP00000016001	Uncharacterized protein.	Cullin 1b; Belongs to the cullin family.	0.750
ENSPREP00000029734	fbxw5	ENSPREP00000029734	ENSPREP00000022269	Uncharacterized protein.	F-box and WD repeat domain containing 5.	0.485
ENSPREP00000029734	rbx1	ENSPREP00000029734	ENSPREP00000026459	Uncharacterized protein.	Ring-box 1, E3 ubiquitin protein ligase.	0.461
ENSPREP00000029734	skp1	ENSPREP00000029734	ENSPREP00000007574	Uncharacterized protein.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.745
FBXL14	cul1	ENSPREP00000006826	ENSPREP00000016001	F-box and leucine rich repeat protein 14.	Cullin 1b; Belongs to the cullin family.	0.758
FBXL14	fbxl18	ENSPREP00000006826	ENSPREP00000000043	F-box and leucine rich repeat protein 14.	F-box and leucine-rich repeat protein 18.	0.455
FBXL14	fbxo33	ENSPREP00000006826	ENSPREP00000007331	F-box and leucine rich repeat protein 14.	F-box protein 33.	0.407
FBXL14	fbxo9	ENSPREP00000006826	ENSPREP00000032660	F-box and leucine rich repeat protein 14.	F-box protein 9.	0.413
FBXL14	fbxw5	ENSPREP00000006826	ENSPREP00000022269	F-box and leucine rich repeat protein 14.	F-box and WD repeat domain containing 5.	0.452
FBXL14	rbx1	ENSPREP00000006826	ENSPREP00000026459	F-box and leucine rich repeat protein 14.	Ring-box 1, E3 ubiquitin protein ligase.	0.759
FBXL14	skp1	ENSPREP00000006826	ENSPREP00000007574	F-box and leucine rich repeat protein 14.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.843
FBXL14	skp2	ENSPREP00000006826	ENSPREP00000008789	F-box and leucine rich repeat protein 14.	F-box domain-containing protein.	0.537
Fbxl17	ENSPREP00000023888	ENSPREP00000023856	ENSPREP00000023888	F-box domain-containing protein.	Uncharacterized protein.	0.900
Fbxl17	cul1	ENSPREP00000023856	ENSPREP00000016001	F-box domain-containing protein.	Cullin 1b; Belongs to the cullin family.	0.958