(40 nodes) Biomineral tissue development network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ecm1	Uncharacterized protein. (482 aa)
	LOC103479413	Otolin 1a. (493 aa)
	LOC103475119	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	tspear	LAM_G_DOMAIN domain-containing protein. (652 aa)
	LOC103459797	Parathyroid hormone-like hormone a. (197 aa)
	ercc2	Excision repair cross-complementation group 2. (655 aa)
	fam20a	FAM20A golgi associated secretory pathway pseudokinase. (536 aa)
	OTOP1	Otopetrin 1. (588 aa)
	LOC103472711	Uncharacterized protein. (418 aa)
	itgb6	Integrin beta; Belongs to the integrin beta chain family. (780 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (471 aa)
	LOC103465552	GATA binding protein 1a. (426 aa)
	ENSPREP00000033037	Uncharacterized protein. (274 aa)
	lgr4	Leucine-rich repeat containing G protein-coupled receptor 4. (913 aa)
	phex	Phosphate regulating endopeptidase homolog, X-linked. (690 aa)
	LOC103477731	Activating transcription factor 4a. (424 aa)
	mdn1	Midasin AAA ATPase 1. (3952 aa)
	ENSPREP00000001981	Uncharacterized protein. (359 aa)
	fbxl15	F-box and leucine-rich repeat protein 15. (294 aa)
	ift80	Intraflagellar transport 80 homolog (Chlamydomonas). (778 aa)
	pth	Uncharacterized protein. (124 aa)
	smpd3	Sphingomyelin phosphodiesterase 3, neutral. (719 aa)
	slc10a7	Solute carrier family 10 member 7. (376 aa)
	LOC103462227	Phosphatase, orphan 2. (244 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (193 aa)
	LOC103469251	FAM20C golgi associated secretory pathway kinase a. (569 aa)
	slc40a1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (566 aa)
	LOC103458736	Thrombospondin-type laminin G domain and EAR repeats a. (701 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1072 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	LOC103465812	Parathyroid hormone-like hormone b. (164 aa)
	Phospho1	Phosphatase, orphan 1. (319 aa)
	clec3b	C-type lectin domain family 3, member Ba. (198 aa)
	LOC103460214	Uncharacterized protein. (269 aa)
	LOC103468683	Gla domain-containing protein. (191 aa)
	atg4b	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (391 aa)
	ENSPREP00000022001	Uncharacterized protein. (123 aa)
	LOC103481136	FAM20C golgi associated secretory pathway kinase. (526 aa)
	nectin1	Nectin cell adhesion molecule 1b. (508 aa)
	pkdcc	Protein kinase domain containing, cytoplasmic b. (526 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000001981	mdn1	ENSPREP00000001981	ENSPREP00000001868	Uncharacterized protein.	Midasin AAA ATPase 1.	0.947
ENSPREP00000033037	Phospho1	ENSPREP00000033037	ENSPREP00000012372	Uncharacterized protein.	Phosphatase, orphan 1.	0.903
LOC103459797	pth	ENSPREP00000027483	ENSPREP00000003110	Parathyroid hormone-like hormone a.	Uncharacterized protein.	0.712
LOC103465812	pth	ENSPREP00000011944	ENSPREP00000003110	Parathyroid hormone-like hormone b.	Uncharacterized protein.	0.712
LOC103469251	fam20a	ENSPREP00000007793	ENSPREP00000028945	FAM20C golgi associated secretory pathway kinase a.	FAM20A golgi associated secretory pathway pseudokinase.	0.973
LOC103469251	phex	ENSPREP00000007793	ENSPREP00000033825	FAM20C golgi associated secretory pathway kinase a.	Phosphate regulating endopeptidase homolog, X-linked.	0.549
LOC103475119	igf1	ENSPREP00000027136	ENSPREP00000010429	Transforming growth factor beta; Belongs to the TGF-beta family.	Insulin-like growth factor 1.	0.630
LOC103475119	itgb6	ENSPREP00000027136	ENSPREP00000029798	Transforming growth factor beta; Belongs to the TGF-beta family.	Integrin beta; Belongs to the integrin beta chain family.	0.958
LOC103477731	eif2ak3	ENSPREP00000000225	ENSPREP00000009940	Activating transcription factor 4a.	Eukaryotic translation initiation factor 2-alpha kinase 3.	0.958
LOC103479413	OTOP1	ENSPREP00000025967	ENSPREP00000029011	Otolin 1a.	Otopetrin 1.	0.541
LOC103481136	fam20a	ENSPREP00000022987	ENSPREP00000028945	FAM20C golgi associated secretory pathway kinase.	FAM20A golgi associated secretory pathway pseudokinase.	0.653
OTOP1	LOC103479413	ENSPREP00000029011	ENSPREP00000025967	Otopetrin 1.	Otolin 1a.	0.541
Phospho1	ENSPREP00000033037	ENSPREP00000012372	ENSPREP00000033037	Phosphatase, orphan 1.	Uncharacterized protein.	0.903
clec3b	ecm1	ENSPREP00000013644	ENSPREP00000024488	C-type lectin domain family 3, member Ba.	Uncharacterized protein.	0.491
ecm1	clec3b	ENSPREP00000024488	ENSPREP00000013644	Uncharacterized protein.	C-type lectin domain family 3, member Ba.	0.491
eif2ak3	LOC103477731	ENSPREP00000009940	ENSPREP00000000225	Eukaryotic translation initiation factor 2-alpha kinase 3.	Activating transcription factor 4a.	0.958
fam20a	LOC103469251	ENSPREP00000028945	ENSPREP00000007793	FAM20A golgi associated secretory pathway pseudokinase.	FAM20C golgi associated secretory pathway kinase a.	0.973
fam20a	LOC103481136	ENSPREP00000028945	ENSPREP00000022987	FAM20A golgi associated secretory pathway pseudokinase.	FAM20C golgi associated secretory pathway kinase.	0.653
igf1	LOC103475119	ENSPREP00000010429	ENSPREP00000027136	Insulin-like growth factor 1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.630
igf1	pth	ENSPREP00000010429	ENSPREP00000003110	Insulin-like growth factor 1.	Uncharacterized protein.	0.549