(36 nodes) Heterochromatin assembly network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103475880	Protein phosphatase, Mg2+/Mn2+ dependent, 1Db. (562 aa)
	ENSPREP00000002305	Nurim. (326 aa)
	LOC103467741	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1451 aa)
	sirt1	Sirtuin 1. (677 aa)
	hat1	Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (379 aa)
	hmga2	Uncharacterized protein. (115 aa)
	lmnb1	Lamin B1; Belongs to the intermediate filament family. (584 aa)
	fam172a	Family with sequence similarity 172 member A. (436 aa)
	bend3	BEN domain containing 3. (814 aa)
	dnmt1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1508 aa)
	cenpv	Centromere protein V. (126 aa)
	LOC103456942	Structural maintenance of chromosomes flexible hinge domain containing 1. (1673 aa)
	LOC103456865	Structural maintenance of chromosomes flexible hinge domain containing 1. (1677 aa)
	rrp8	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (496 aa)
	LOC103463654	Methyl-CpG binding domain protein 3a. (274 aa)
	dot1l	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1584 aa)
	pole3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (173 aa)
	LOC103473032	Uncharacterized protein; Belongs to the intermediate filament family. (643 aa)
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (770 aa)
	znfx1	Zinc finger, NFX1-type containing 1. (1816 aa)
	ENSPREP00000014132	Uncharacterized protein. (138 aa)
	ezh2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (762 aa)
	dicer1	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily. (1860 aa)
	mecp2	Methyl CpG binding protein 2. (982 aa)
	LOC103460256	Methyl-CpG binding domain protein 2. (302 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (552 aa)
	LOC103457884	BAH domain-containing protein. (792 aa)
	bahd1	Bromo adjacent homology domain containing 1. (825 aa)
	lmna	Lamin A; Belongs to the intermediate filament family. (642 aa)
	LOC103479463	Sirtuin 6. (339 aa)
	LOC103479450	Uncharacterized protein. (251 aa)
	rif1	Replication timing regulatory factor 1. (2323 aa)
	spty2d1	SPT2 chromatin protein domain containing 1. (705 aa)
	hells	Helicase, lymphoid specific. (854 aa)
	lmnb2	Lamin B2; Belongs to the intermediate filament family. (579 aa)
	ENSPREP00000032744	Retinoblastoma 1. (864 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000014132	LOC103467741	ENSPREP00000014132	ENSPREP00000002810	Uncharacterized protein.	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.663
ENSPREP00000014132	dnmt1	ENSPREP00000014132	ENSPREP00000009697	Uncharacterized protein.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.820
ENSPREP00000014132	dot1l	ENSPREP00000014132	ENSPREP00000013260	Uncharacterized protein.	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	0.413
ENSPREP00000014132	hells	ENSPREP00000014132	ENSPREP00000030052	Uncharacterized protein.	Helicase, lymphoid specific.	0.463
ENSPREP00000014132	sirt1	ENSPREP00000014132	ENSPREP00000003960	Uncharacterized protein.	Sirtuin 1.	0.532
EZH1	LOC103467741	ENSPREP00000013900	ENSPREP00000002810	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.663
EZH1	dnmt1	ENSPREP00000013900	ENSPREP00000009697	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.820
EZH1	dot1l	ENSPREP00000013900	ENSPREP00000013260	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	0.413
EZH1	hells	ENSPREP00000013900	ENSPREP00000030052	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Helicase, lymphoid specific.	0.463
EZH1	sirt1	ENSPREP00000013900	ENSPREP00000003960	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Sirtuin 1.	0.532
LOC103460256	dnmt1	ENSPREP00000019886	ENSPREP00000009697	Methyl-CpG binding domain protein 2.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.501
LOC103463654	LOC103467741	ENSPREP00000012581	ENSPREP00000002810	Methyl-CpG binding domain protein 3a.	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.545
LOC103463654	dnmt1	ENSPREP00000012581	ENSPREP00000009697	Methyl-CpG binding domain protein 3a.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.501
LOC103463654	mecp2	ENSPREP00000012581	ENSPREP00000018569	Methyl-CpG binding domain protein 3a.	Methyl CpG binding protein 2.	0.494
LOC103467741	ENSPREP00000014132	ENSPREP00000002810	ENSPREP00000014132	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.663
LOC103467741	EZH1	ENSPREP00000002810	ENSPREP00000013900	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.663
LOC103467741	LOC103463654	ENSPREP00000002810	ENSPREP00000012581	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Methyl-CpG binding domain protein 3a.	0.545
LOC103467741	dnmt1	ENSPREP00000002810	ENSPREP00000009697	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.989
LOC103467741	ezh2	ENSPREP00000002810	ENSPREP00000015919	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.663
LOC103467741	hells	ENSPREP00000002810	ENSPREP00000030052	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Helicase, lymphoid specific.	0.465