(44 nodes) Negative regulation of TOR signaling network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ddit4	DNA-damage-inducible transcript 4. (274 aa)
	sirt1	Sirtuin 1. (677 aa)
	fnip1	Folliculin interacting protein 1. (1222 aa)
	nprl2	NPR2 like, GATOR1 complex subunit. (381 aa)
	sesn1	Sestrin 1. (492 aa)
	LOC103472311	Sestrin 2. (558 aa)
	CASTOR1	Cytosolic arginine sensor for mTORC1 subunit 1. (332 aa)
	itfg2	Integrin alpha FG-GAP repeat containing 2. (490 aa)
	LOC103472964	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (449 aa)
	ENSPREP00000010666	Uncharacterized protein. (64 aa)
	ENSPREP00000011155	Uncharacterized protein. (74 aa)
	Nprl3	NPR3-like, GATOR1 complex subunit. (206 aa)
	flcn	Folliculin. (554 aa)
	LOC103471661	Si:zfos-80g12.1. (444 aa)
	tmem127	Transmembrane protein 127. (237 aa)
	deptor	DEP domain containing MTOR-interacting protein. (397 aa)
	LOC103463399	TBC1 domain family, member 7. (355 aa)
	depdc5	DEP domain containing 5. (1581 aa)
	akt1s1	AKT1 substrate 1 (proline-rich). (353 aa)
	kptn	Kaptin (actin binding protein). (440 aa)
	ENSPREP00000017971	CBM21 domain-containing protein. (266 aa)
	bmt2	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (391 aa)
	UBR1	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (985 aa)
	Ubr1	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (394 aa)
	Ubr2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (355 aa)
	ENSPREP00000020241	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (188 aa)
	gsk3a	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (438 aa)
	castor2	Cytosolic arginine sensor for mTORC1 subunit 2. (328 aa)
	mapkapk5	MAPK activated protein kinase 5. (471 aa)
	LOC103482389	SH3-domain binding protein 4. (962 aa)
	atm	Non-specific serine/threonine protein kinase. (3091 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
	SZT2	SZT2 subunit of KICSTOR complex. (2242 aa)
	Szt2	Uncharacterized protein. (100 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (557 aa)
	LOC103457333	SH3-domain binding protein 4a. (960 aa)
	tsc1	TSC complex subunit 1b. (1243 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (637 aa)
	clg23h12orf66	Si:ch211-125a15.1. (451 aa)
	LOC103465557	Si:dkeyp-97e7.9. (414 aa)
	rnf152	Ring finger protein 152. (177 aa)
	minar1	UPF0258 domain-containing protein. (815 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
	tsc2	TSC complex subunit 2. (1898 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASTOR1	ENSPREP00000010666	ENSPREP00000007501	ENSPREP00000010666	Cytosolic arginine sensor for mTORC1 subunit 1.	Uncharacterized protein.	0.432
CASTOR1	ENSPREP00000011155	ENSPREP00000007501	ENSPREP00000011155	Cytosolic arginine sensor for mTORC1 subunit 1.	Uncharacterized protein.	0.432
CASTOR1	Nprl3	ENSPREP00000007501	ENSPREP00000011200	Cytosolic arginine sensor for mTORC1 subunit 1.	NPR3-like, GATOR1 complex subunit.	0.432
CASTOR1	SZT2	ENSPREP00000007501	ENSPREP00000028868	Cytosolic arginine sensor for mTORC1 subunit 1.	SZT2 subunit of KICSTOR complex.	0.419
CASTOR1	castor2	ENSPREP00000007501	ENSPREP00000021192	Cytosolic arginine sensor for mTORC1 subunit 1.	Cytosolic arginine sensor for mTORC1 subunit 2.	0.902
CASTOR1	clg23h12orf66	ENSPREP00000007501	ENSPREP00000032224	Cytosolic arginine sensor for mTORC1 subunit 1.	Si:ch211-125a15.1.	0.629
CASTOR1	depdc5	ENSPREP00000007501	ENSPREP00000015297	Cytosolic arginine sensor for mTORC1 subunit 1.	DEP domain containing 5.	0.598
CASTOR1	itfg2	ENSPREP00000007501	ENSPREP00000010156	Cytosolic arginine sensor for mTORC1 subunit 1.	Integrin alpha FG-GAP repeat containing 2.	0.633
CASTOR1	kptn	ENSPREP00000007501	ENSPREP00000017212	Cytosolic arginine sensor for mTORC1 subunit 1.	Kaptin (actin binding protein).	0.583
CASTOR1	nprl2	ENSPREP00000007501	ENSPREP00000006928	Cytosolic arginine sensor for mTORC1 subunit 1.	NPR2 like, GATOR1 complex subunit.	0.518
ENSPREP00000010666	CASTOR1	ENSPREP00000010666	ENSPREP00000007501	Uncharacterized protein.	Cytosolic arginine sensor for mTORC1 subunit 1.	0.432
ENSPREP00000010666	ENSPREP00000017971	ENSPREP00000010666	ENSPREP00000017971	Uncharacterized protein.	CBM21 domain-containing protein.	0.519
ENSPREP00000010666	LOC103471661	ENSPREP00000010666	ENSPREP00000012834	Uncharacterized protein.	Si:zfos-80g12.1.	0.591
ENSPREP00000010666	LOC103472311	ENSPREP00000010666	ENSPREP00000007336	Uncharacterized protein.	Sestrin 2.	0.622
ENSPREP00000010666	SZT2	ENSPREP00000010666	ENSPREP00000028868	Uncharacterized protein.	SZT2 subunit of KICSTOR complex.	0.911
ENSPREP00000010666	bmt2	ENSPREP00000010666	ENSPREP00000018129	Uncharacterized protein.	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	0.519
ENSPREP00000010666	castor2	ENSPREP00000010666	ENSPREP00000021192	Uncharacterized protein.	Cytosolic arginine sensor for mTORC1 subunit 2.	0.432
ENSPREP00000010666	clg23h12orf66	ENSPREP00000010666	ENSPREP00000032224	Uncharacterized protein.	Si:ch211-125a15.1.	0.662
ENSPREP00000010666	depdc5	ENSPREP00000010666	ENSPREP00000015297	Uncharacterized protein.	DEP domain containing 5.	0.957
ENSPREP00000010666	itfg2	ENSPREP00000010666	ENSPREP00000010156	Uncharacterized protein.	Integrin alpha FG-GAP repeat containing 2.	0.652