(50 nodes) Regulation of telomere maintenance network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	map3k4	Mitogen-activated protein kinase kinase kinase 4. (1587 aa)
	naf1	Uncharacterized protein. (481 aa)
	gnl3l	Guanine nucleotide binding protein-like 3 (nucleolar)-like. (551 aa)
	LOC103469721	Poly [ADP-ribose] polymerase. (1263 aa)
	ylpm1	YLP motif containing 1. (1716 aa)
	ten1	TEN1 subunit of CST complex. (134 aa)
	nfrkb	Nuclear factor related to kappaB binding protein. (1283 aa)
	LOC103466742	Uncharacterized protein. (442 aa)
	pinx1	PIN2 (TERF1) interacting telomerase inhibitor 1. (378 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (418 aa)
	terf1	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (367 aa)
	smg5	SMG5 nonsense mediated mRNA decay factor. (1113 aa)
	LOC103479463	Sirtuin 6. (339 aa)
	ercc4	Excision repair cross-complementation group 4. (893 aa)
	pot1	Telo_bind domain-containing protein. (763 aa)
	atm	Non-specific serine/threonine protein kinase. (3091 aa)
	fbxo4	F-box protein 4. (361 aa)
	exosc10	Exosome component 10. (892 aa)
	nat10	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (955 aa)
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (619 aa)
	cct3	T-complex protein 1 subunit gamma. (540 aa)
	mapkapk5	MAPK activated protein kinase 5. (471 aa)
	mcrs1	Microspherule protein 1. (474 aa)
	cct5	Chaperonin containing TCP1, subunit 5 (epsilon). (541 aa)
	ino80	INO80 complex ATPase subunit. (1484 aa)
	ino80e	INO80 complex subunit E. (211 aa)
	LOC103465252	Coiled-coil domain containing 174. (548 aa)
	terf2	HTH myb-type domain-containing protein. (635 aa)
	ppp1r10	Protein phosphatase 1, regulatory subunit 10. (805 aa)
	dcp2	Decapping mRNA 2. (398 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2589 aa)
	smg1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3658 aa)
	uchl5	Ubiquitin carboxyl-terminal hydrolase. (339 aa)
	ercc1	Excision repair cross-complementation group 1. (358 aa)
	smg6	SMG6 nonsense mediated mRNA decay factor. (1607 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (731 aa)
	LOC103475985	TERF1 (TRF1)-interacting nuclear factor 2. (560 aa)
	atrx	ATRX chromatin remodeler. (2188 aa)
	dkc1	Dyskeratosis congenita 1, dyskerin. (553 aa)
	rtel1	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1180 aa)
	pnkp	Polynucleotide kinase 3'-phosphatase. (593 aa)
	tfpt	TCF3 (E2A) fusion partner. (199 aa)
	nek2	NIMA-related kinase 2. (352 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1355 aa)
	LOC103473565	Poly [ADP-ribose] polymerase. (1285 aa)
	ino80d	INO80 complex subunit Da. (1025 aa)
	cct2	Chaperonin containing TCP1, subunit 2 (beta). (535 aa)
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1057 aa)
	slx4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1463 aa)
	LOC103480107	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (263 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103466742	LOC103475985	ENSPREP00000028462	ENSPREP00000006753	Uncharacterized protein.	TERF1 (TRF1)-interacting nuclear factor 2.	0.991
LOC103466742	dkc1	ENSPREP00000028462	ENSPREP00000005982	Uncharacterized protein.	Dyskeratosis congenita 1, dyskerin.	0.661
LOC103466742	pot1	ENSPREP00000028462	ENSPREP00000024452	Uncharacterized protein.	Telo_bind domain-containing protein.	0.988
LOC103466742	rtel1	ENSPREP00000028462	ENSPREP00000012657	Uncharacterized protein.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.508
LOC103466742	ten1	ENSPREP00000028462	ENSPREP00000028848	Uncharacterized protein.	TEN1 subunit of CST complex.	0.749
LOC103466742	terf1	ENSPREP00000028462	ENSPREP00000026481	Uncharacterized protein.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.973
LOC103466742	terf2	ENSPREP00000028462	ENSPREP00000018221	Uncharacterized protein.	HTH myb-type domain-containing protein.	0.982
LOC103469721	LOC103475985	ENSPREP00000029282	ENSPREP00000006753	Poly [ADP-ribose] polymerase.	TERF1 (TRF1)-interacting nuclear factor 2.	0.496
LOC103469721	terf1	ENSPREP00000029282	ENSPREP00000026481	Poly [ADP-ribose] polymerase.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.714
LOC103473565	LOC103475985	ENSPREP00000008753	ENSPREP00000006753	Poly [ADP-ribose] polymerase.	TERF1 (TRF1)-interacting nuclear factor 2.	0.496
LOC103473565	terf1	ENSPREP00000008753	ENSPREP00000026481	Poly [ADP-ribose] polymerase.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.714
LOC103475985	LOC103466742	ENSPREP00000006753	ENSPREP00000028462	TERF1 (TRF1)-interacting nuclear factor 2.	Uncharacterized protein.	0.991
LOC103475985	LOC103469721	ENSPREP00000006753	ENSPREP00000029282	TERF1 (TRF1)-interacting nuclear factor 2.	Poly [ADP-ribose] polymerase.	0.496
LOC103475985	LOC103473565	ENSPREP00000006753	ENSPREP00000008753	TERF1 (TRF1)-interacting nuclear factor 2.	Poly [ADP-ribose] polymerase.	0.496
LOC103475985	atm	ENSPREP00000006753	ENSPREP00000024388	TERF1 (TRF1)-interacting nuclear factor 2.	Non-specific serine/threonine protein kinase.	0.411
LOC103475985	atrx	ENSPREP00000006753	ENSPREP00000006575	TERF1 (TRF1)-interacting nuclear factor 2.	ATRX chromatin remodeler.	0.562
LOC103475985	dkc1	ENSPREP00000006753	ENSPREP00000005982	TERF1 (TRF1)-interacting nuclear factor 2.	Dyskeratosis congenita 1, dyskerin.	0.817
LOC103475985	pot1	ENSPREP00000006753	ENSPREP00000024452	TERF1 (TRF1)-interacting nuclear factor 2.	Telo_bind domain-containing protein.	0.991
LOC103475985	rad50	ENSPREP00000006753	ENSPREP00000008829	TERF1 (TRF1)-interacting nuclear factor 2.	RAD50 homolog, double strand break repair protein.	0.547
LOC103475985	rtel1	ENSPREP00000006753	ENSPREP00000012657	TERF1 (TRF1)-interacting nuclear factor 2.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.742