(35 nodes) Negative regulation of intracellular transport network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ube2j1	Ubiquitin-conjugating enzyme E2, J1. (275 aa)
	bag3	BCL2 associated athanogene 3. (516 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2573 aa)
	LOC103469840	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (234 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (193 aa)
	snx3	Sorting nexin 3. (162 aa)
	derl2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (276 aa)
	ARHGAP8	Rho GTPase activating protein 8. (459 aa)
	nup153	Nucleoporin 153. (1518 aa)
	cdk5	Cyclin-dependent kinase 5. (262 aa)
	tpr	Translocated promoter region b, nuclear basket protein. (2383 aa)
	bag4	BCL2 associated athanogene 4. (377 aa)
	clg20h11orf65	Uncharacterized protein. (289 aa)
	bard1	BRCA1 associated RING domain 1. (722 aa)
	Pln	Uncharacterized protein. (180 aa)
	LOC103479802	Apolipoprotein Da, duplicate 1; Belongs to the calycin superfamily. Lipocalin family. (186 aa)
	svip	Si:ch73-147o17.1. (80 aa)
	cep131	Centrosomal protein 131. (1215 aa)
	nf1	Neurofibromin 1b. (2742 aa)
	ENSPREP00000021545	Uncharacterized protein. (255 aa)
	LOC103479306	Translocated promoter region a, nuclear basket protein. (1861 aa)
	os9	OS9 endoplasmic reticulum lectin. (705 aa)
	LOC103475461	Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family. (164 aa)
	LOC103479463	Sirtuin 6. (339 aa)
	arhgap1	Uncharacterized protein. (430 aa)
	rangap1	RAN GTPase activating protein 1a. (575 aa)
	ube2g2	Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast). (154 aa)
	chp1	Calcineurin-like EF-hand protein 1. (154 aa)
	pkig	Protein kinase (cAMP-dependent, catalytic) inhibitor gamma. (127 aa)
	LOC103481999	Ran GTPase activating protein 1b. (567 aa)
	pcsk9	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (671 aa)
	vps35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (798 aa)
	rab23	RAB23, member RAS oncogene family. (204 aa)
	erlec1	Endoplasmic reticulum lectin 1. (498 aa)
	LOC103456761	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family. (182 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP8	arhgap1	ENSPREP00000009788	ENSPREP00000026198	Rho GTPase activating protein 8.	Uncharacterized protein.	0.403
ENSPREP00000021545	LOC103479306	ENSPREP00000021545	ENSPREP00000021669	Uncharacterized protein.	Translocated promoter region a, nuclear basket protein.	0.941
ENSPREP00000021545	LOC103481999	ENSPREP00000021545	ENSPREP00000030639	Uncharacterized protein.	Ran GTPase activating protein 1b.	0.483
ENSPREP00000021545	nup153	ENSPREP00000021545	ENSPREP00000010926	Uncharacterized protein.	Nucleoporin 153.	0.886
ENSPREP00000021545	rangap1	ENSPREP00000021545	ENSPREP00000026307	Uncharacterized protein.	RAN GTPase activating protein 1a.	0.483
LOC103469840	derl2	ENSPREP00000005741	ENSPREP00000009081	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.901
LOC103469840	erlec1	ENSPREP00000005741	ENSPREP00000033924	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Endoplasmic reticulum lectin 1.	0.933
LOC103469840	os9	ENSPREP00000005741	ENSPREP00000025152	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	OS9 endoplasmic reticulum lectin.	0.933
LOC103469840	ube2g2	ENSPREP00000005741	ENSPREP00000027103	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast).	0.440
LOC103469840	ube2j1	ENSPREP00000005741	ENSPREP00000001669	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ubiquitin-conjugating enzyme E2, J1.	0.512
LOC103475461	bag3	ENSPREP00000025993	ENSPREP00000003708	Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family.	BCL2 associated athanogene 3.	0.683
LOC103479306	ENSPREP00000021545	ENSPREP00000021669	ENSPREP00000021545	Translocated promoter region a, nuclear basket protein.	Uncharacterized protein.	0.941
LOC103479306	LOC103481999	ENSPREP00000021669	ENSPREP00000030639	Translocated promoter region a, nuclear basket protein.	Ran GTPase activating protein 1b.	0.483
LOC103479306	nup153	ENSPREP00000021669	ENSPREP00000010926	Translocated promoter region a, nuclear basket protein.	Nucleoporin 153.	0.886
LOC103479306	rangap1	ENSPREP00000021669	ENSPREP00000026307	Translocated promoter region a, nuclear basket protein.	RAN GTPase activating protein 1a.	0.483
LOC103481999	ENSPREP00000021545	ENSPREP00000030639	ENSPREP00000021545	Ran GTPase activating protein 1b.	Uncharacterized protein.	0.483
LOC103481999	LOC103479306	ENSPREP00000030639	ENSPREP00000021669	Ran GTPase activating protein 1b.	Translocated promoter region a, nuclear basket protein.	0.483
LOC103481999	nup153	ENSPREP00000030639	ENSPREP00000010926	Ran GTPase activating protein 1b.	Nucleoporin 153.	0.788
LOC103481999	rangap1	ENSPREP00000030639	ENSPREP00000026307	Ran GTPase activating protein 1b.	RAN GTPase activating protein 1a.	0.902
LOC103481999	tpr	ENSPREP00000030639	ENSPREP00000013181	Ran GTPase activating protein 1b.	Translocated promoter region b, nuclear basket protein.	0.483