(60 nodes) Regulation of peptidyl-serine phosphorylation network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	LOC103462295	Zgc:153993. (263 aa)
	ret	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1118 aa)
	Cav1	Uncharacterized protein. (84 aa)
	rptor	Regulatory associated protein of MTOR, complex 1. (1350 aa)
	paqr3	Progestin and adipoQ receptor family member IIIa. (347 aa)
	epm2a	EPM2A glucan phosphatase, laforin. (196 aa)
	fnip1	Folliculin interacting protein 1. (1222 aa)
	bcl2	BCL2 apoptosis regulator b. (230 aa)
	LOC103465711	Protein phosphatase 1, regulatory subunit 15B. (553 aa)
	BDKRB2	Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	ENSPREP00000007409	NGF domain-containing protein; Belongs to the NGF-beta family. (273 aa)
	LOC103473559	Progestin and adipoQ receptor family member IIIb. (315 aa)
	LOC103460020	Nuclear receptor binding SET domain protein 1b. (1315 aa)
	LOC103471190	Nuclear receptor binding SET domain protein 1a. (2016 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (582 aa)
	LOC103473631	SH2 domain containing 3Ca. (708 aa)
	LOC103462114	SH2 domain containing 3A. (804 aa)
	BAX	BCL2 associated X, apoptosis regulator. (191 aa)
	LOC103476047	Sprouty RTK signaling antagonist 2. (349 aa)
	ptgs2	Prostaglandin-endoperoxide synthase 2b. (615 aa)
	LOC103478037	Interleukin 11a. (200 aa)
	nck2	Cytoplasmic protein. (393 aa)
	LOC103465217	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (159 aa)
	bag4	BCL2 associated athanogene 4. (377 aa)
	LOC103474901	Inositol polyphosphate-5-phosphatase Ka. (535 aa)
	rictor	RPTOR independent companion of MTOR, complex 2 a. (1760 aa)
	mad2l2	Mitotic arrest deficient 2 like 2. (192 aa)
	LOC103473692	Inositol polyphosphate-5-phosphatase Ja. (536 aa)
	ENSPREP00000015747	Uncharacterized protein. (47 aa)
	SMYD3	SET and MYND domain containing 3. (443 aa)
	RAMP3	Receptor activity modifying protein 3. (164 aa)
	ENSPREP00000016463	Uncharacterized protein. (111 aa)
	LOC108167267	Uncharacterized protein. (184 aa)
	LOC103468988	NGF domain-containing protein; Belongs to the NGF-beta family. (339 aa)
	mapkap1	MAPK associated protein 1. (525 aa)
	pwp1	PWP1 homolog, endonuclein. (493 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	ENSPREP00000018105	Uncharacterized protein. (204 aa)
	sh2d3c	SH2 domain containing 3Cb. (685 aa)
	LOC103479350	Zgc:171558. (952 aa)
	LOC103476799	Dickkopf WNT signaling pathway inhibitor 1a. (242 aa)
	LOC103475499	Inositol polyphosphate-5-phosphatase Kb. (522 aa)
	ntf3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (304 aa)
	ENSPREP00000022997	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (200 aa)
	oxt	Arginine vasopressin; Belongs to the vasopressin/oxytocin family. (138 aa)
	LOC103475119	Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
	ucn	Urotensin 1. (147 aa)
	stox1	Storkhead box 1. (982 aa)
	LOC103474475	Uncharacterized protein. (342 aa)
	LOC103467432	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family. (286 aa)
	hax1	HCLS1 associated protein X-1. (288 aa)
	LOC103470979	Teneurin transmembrane protein 1. (2672 aa)
	ercc6	Excision repair cross-complementation group 6. (1402 aa)
	LOC103470276	Inositol polyphosphate-5-phosphatase Jb. (602 aa)
	nck1	Cytoplasmic protein. (394 aa)
	gas6	Uncharacterized protein. (650 aa)
	pink1	PTEN induced kinase 1. (575 aa)
	LOC103467797	Rap guanine nucleotide exchange factor (GEF) 3. (878 aa)
	bcar3	BCAR3 adaptor protein, NSP family member. (743 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAX	LOC103462295	ENSPREP00000013021	ENSPREP00000002464	BCL2 associated X, apoptosis regulator.	Zgc:153993.	0.988
BAX	bcl2	ENSPREP00000013021	ENSPREP00000006116	BCL2 associated X, apoptosis regulator.	BCL2 apoptosis regulator b.	0.995
ENSPREP00000007409	LOC103467432	ENSPREP00000007409	ENSPREP00000029097	NGF domain-containing protein; Belongs to the NGF-beta family.	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family.	0.905
ENSPREP00000007409	ripk2	ENSPREP00000007409	ENSPREP00000009886	NGF domain-containing protein; Belongs to the NGF-beta family.	Receptor-interacting serine-threonine kinase 2.	0.453
ENSPREP00000016463	LOC108167267	ENSPREP00000016463	ENSPREP00000016520	Uncharacterized protein.	Uncharacterized protein.	0.492
ENSPREP00000018105	LOC108167267	ENSPREP00000018105	ENSPREP00000016520	Uncharacterized protein.	Uncharacterized protein.	0.577
LOC103462295	BAX	ENSPREP00000002464	ENSPREP00000013021	Zgc:153993.	BCL2 associated X, apoptosis regulator.	0.988
LOC103462295	bcl2	ENSPREP00000002464	ENSPREP00000006116	Zgc:153993.	BCL2 apoptosis regulator b.	0.981
LOC103467432	ENSPREP00000007409	ENSPREP00000029097	ENSPREP00000007409	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family.	NGF domain-containing protein; Belongs to the NGF-beta family.	0.905
LOC103467432	ripk2	ENSPREP00000029097	ENSPREP00000009886	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family.	Receptor-interacting serine-threonine kinase 2.	0.453
LOC103473692	LOC103474901	ENSPREP00000015723	ENSPREP00000014303	Inositol polyphosphate-5-phosphatase Ja.	Inositol polyphosphate-5-phosphatase Ka.	0.900
LOC103473692	LOC103475499	ENSPREP00000015723	ENSPREP00000022548	Inositol polyphosphate-5-phosphatase Ja.	Inositol polyphosphate-5-phosphatase Kb.	0.900
LOC103474475	LOC103476799	ENSPREP00000028750	ENSPREP00000021364	Uncharacterized protein.	Dickkopf WNT signaling pathway inhibitor 1a.	0.436
LOC103474901	LOC103473692	ENSPREP00000014303	ENSPREP00000015723	Inositol polyphosphate-5-phosphatase Ka.	Inositol polyphosphate-5-phosphatase Ja.	0.900
LOC103474901	LOC103475499	ENSPREP00000014303	ENSPREP00000022548	Inositol polyphosphate-5-phosphatase Ka.	Inositol polyphosphate-5-phosphatase Kb.	0.901
LOC103475499	LOC103473692	ENSPREP00000022548	ENSPREP00000015723	Inositol polyphosphate-5-phosphatase Kb.	Inositol polyphosphate-5-phosphatase Ja.	0.900
LOC103475499	LOC103474901	ENSPREP00000022548	ENSPREP00000014303	Inositol polyphosphate-5-phosphatase Kb.	Inositol polyphosphate-5-phosphatase Ka.	0.901
LOC103476799	LOC103474475	ENSPREP00000021364	ENSPREP00000028750	Dickkopf WNT signaling pathway inhibitor 1a.	Uncharacterized protein.	0.436
LOC103476799	sfrp2	ENSPREP00000021364	ENSPREP00000000067	Dickkopf WNT signaling pathway inhibitor 1a.	Secreted frizzled-related protein 2.	0.436
LOC108167267	ENSPREP00000016463	ENSPREP00000016520	ENSPREP00000016463	Uncharacterized protein.	Uncharacterized protein.	0.492