(33 nodes) Tumor necrosis factor-mediated signaling pathway network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tnfsf13b	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (260 aa)
	ENSPREP00000003551	Caspase recruitment domain family, member 14. (729 aa)
	ENSPREP00000003758	Pyrin domain-containing protein. (110 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
	LOC103477745	Tumor necrosis factor b (TNF superfamily, member 2). (249 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (590 aa)
	LOC103471097	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (239 aa)
	LOC103464471	Tumor necrosis factor receptor superfamily, member 1B. (441 aa)
	cdip1	Cell death-inducing p53 target 1. (223 aa)
	LOC103468700	LITAF domain-containing protein. (199 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (315 aa)
	ST18	ST18 C2H2C-type zinc finger transcription factor. (1139 aa)
	ILK	Integrin linked kinase. (452 aa)
	LOC103479149	Uncharacterized protein. (678 aa)
	tnfrsf1a	Tumor necrosis factor receptor superfamily, member 1a. (333 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (743 aa)
	LOC103463294	Plasmalemma vesicle associated protein b. (460 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (772 aa)
	LOC103469572	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	ilk	Uncharacterized protein. (465 aa)
	LOC103473816	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (532 aa)
	tnfrsf11a	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator. (567 aa)
	TNFRSF19	TNF receptor superfamily member 19. (319 aa)
	ENSPREP00000024365	LITAF domain-containing protein. (239 aa)
	ENSPREP00000026492	SEFIR domain-containing protein. (109 aa)
	LOC103457805	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (301 aa)
	LOC103473320	TNF receptor-associated factor. (494 aa)
	commd7	COMM domain containing 7. (198 aa)
	ENSPREP00000029772	Zgc:174906. (216 aa)
	tnfsf11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (268 aa)
	ENSPREP00000030454	CARD domain-containing protein. (104 aa)
	traf3ip2	SEFIR domain-containing protein. (418 aa)
	LOC103476976	Component of inhibitor of nuclear factor kappa B kinase complex. (689 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	LOC103457805	ENSPREP00000020163	ENSPREP00000027480	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.958
CHUK	LOC103469572	ENSPREP00000020163	ENSPREP00000021110	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.593
CHUK	LOC103473320	ENSPREP00000020163	ENSPREP00000028561	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor.	0.593
CHUK	LOC103473816	ENSPREP00000020163	ENSPREP00000022240	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.593
CHUK	LOC103476976	ENSPREP00000020163	ENSPREP00000032137	Component of inhibitor of nuclear factor kappa B kinase complex.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.943
CHUK	ikbkb	ENSPREP00000020163	ENSPREP00000016563	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.950
CHUK	nfkbia	ENSPREP00000020163	ENSPREP00000012072	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.958
CHUK	tnfrsf1a	ENSPREP00000020163	ENSPREP00000016244	Component of inhibitor of nuclear factor kappa B kinase complex.	Tumor necrosis factor receptor superfamily, member 1a.	0.577
CHUK	traf3	ENSPREP00000020163	ENSPREP00000006242	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.762
CHUK	traf6	ENSPREP00000020163	ENSPREP00000005082	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.983
ENSPREP00000003551	traf6	ENSPREP00000003551	ENSPREP00000005082	Caspase recruitment domain family, member 14.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.414
ENSPREP00000026492	LOC103469572	ENSPREP00000026492	ENSPREP00000021110	SEFIR domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.410
ENSPREP00000026492	LOC103473320	ENSPREP00000026492	ENSPREP00000028561	SEFIR domain-containing protein.	TNF receptor-associated factor.	0.410
ENSPREP00000026492	LOC103473816	ENSPREP00000026492	ENSPREP00000022240	SEFIR domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.410
ENSPREP00000026492	traf3	ENSPREP00000026492	ENSPREP00000006242	SEFIR domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.584
ENSPREP00000026492	traf3ip2	ENSPREP00000026492	ENSPREP00000030465	SEFIR domain-containing protein.	SEFIR domain-containing protein.	0.900
ENSPREP00000026492	traf6	ENSPREP00000026492	ENSPREP00000005082	SEFIR domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.818
ILK	ilk	ENSPREP00000012407	ENSPREP00000021435	Integrin linked kinase.	Uncharacterized protein.	0.901
LOC103457805	CHUK	ENSPREP00000027480	ENSPREP00000020163	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.958
LOC103457805	LOC103476976	ENSPREP00000027480	ENSPREP00000032137	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.988