(23 nodes) Fin morphogenesis network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103473783	Nipped-B protein. (2642 aa)
	hand2	Heart and neural crest derivatives expressed 2. (226 aa)
	nipbl	Nipped-B protein. (2355 aa)
	LOC103473796	T-box transcription factor 5a. (524 aa)
	ENSPREP00000020767	Uncharacterized protein. (110 aa)
	med12	Mediator complex subunit 12. (2052 aa)
	ENSPREP00000018776	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (824 aa)
	crbn	Cereblon. (407 aa)
	LOC103465916	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (689 aa)
	chrd	Chordin; Belongs to the chordin family. (949 aa)
	FBLN1	Fibulin 1. (509 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (427 aa)
	LOC103470513	Metalloendopeptidase. (970 aa)
	sp9	Sp9 transcription factor. (439 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (865 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
	sec23a	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (764 aa)
	ENSPREP00000006071	Fin bud initiation factor b. (280 aa)
	dlx6	Distal-less homeobox 6a. (246 aa)
	dlx5	Distal-less homeobox 5a. (286 aa)
	LOC103478554	Sp8 transcription factor b. (454 aa)
	gja1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (387 aa)
	tll1	Metalloendopeptidase. (1027 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH2	gja1	ENSPREP00000007079	ENSPREP00000000836	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.559
ENSPREP00000018776	gja1	ENSPREP00000018776	ENSPREP00000000836	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.458
ENSPREP00000020767	LOC103473783	ENSPREP00000020767	ENSPREP00000020900	Uncharacterized protein.	Nipped-B protein.	0.899
LOC103470513	chrd	ENSPREP00000010081	ENSPREP00000014581	Metalloendopeptidase.	Chordin; Belongs to the chordin family.	0.849
LOC103473783	ENSPREP00000020767	ENSPREP00000020900	ENSPREP00000020767	Nipped-B protein.	Uncharacterized protein.	0.899
LOC103473796	hand2	ENSPREP00000021410	ENSPREP00000032725	T-box transcription factor 5a.	Heart and neural crest derivatives expressed 2.	0.590
chrd	LOC103470513	ENSPREP00000014581	ENSPREP00000010081	Chordin; Belongs to the chordin family.	Metalloendopeptidase.	0.849
chrd	tll1	ENSPREP00000014581	ENSPREP00000000107	Chordin; Belongs to the chordin family.	Metalloendopeptidase.	0.849
dlx5	dlx6	ENSPREP00000002911	ENSPREP00000002931	Distal-less homeobox 5a.	Distal-less homeobox 6a.	0.838
dlx5	hand2	ENSPREP00000002911	ENSPREP00000032725	Distal-less homeobox 5a.	Heart and neural crest derivatives expressed 2.	0.402
dlx6	dlx5	ENSPREP00000002931	ENSPREP00000002911	Distal-less homeobox 6a.	Distal-less homeobox 5a.	0.838
dlx6	hand2	ENSPREP00000002931	ENSPREP00000032725	Distal-less homeobox 6a.	Heart and neural crest derivatives expressed 2.	0.408
gja1	CDH2	ENSPREP00000000836	ENSPREP00000007079	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	0.559
gja1	ENSPREP00000018776	ENSPREP00000000836	ENSPREP00000018776	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.458
hand2	LOC103473796	ENSPREP00000032725	ENSPREP00000021410	Heart and neural crest derivatives expressed 2.	T-box transcription factor 5a.	0.590
hand2	dlx5	ENSPREP00000032725	ENSPREP00000002911	Heart and neural crest derivatives expressed 2.	Distal-less homeobox 5a.	0.402
hand2	dlx6	ENSPREP00000032725	ENSPREP00000002931	Heart and neural crest derivatives expressed 2.	Distal-less homeobox 6a.	0.408
tll1	chrd	ENSPREP00000000107	ENSPREP00000014581	Metalloendopeptidase.	Chordin; Belongs to the chordin family.	0.849