(13 nodes) Medial fin development network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tll1	Metalloendopeptidase. (1027 aa)
	gja1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (387 aa)
	smyd2	Uncharacterized protein. (499 aa)
	dlx5	Distal-less homeobox 5a. (286 aa)
	dlx6	Distal-less homeobox 6a. (246 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (865 aa)
	LOC103470513	Metalloendopeptidase. (970 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (427 aa)
	FBLN1	Fibulin 1. (509 aa)
	chrd	Chordin; Belongs to the chordin family. (949 aa)
	LOC103465916	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (689 aa)
	ENSPREP00000018776	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (824 aa)
	rspo2	R-spondin 2. (245 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH2	gja1	ENSPREP00000007079	ENSPREP00000000836	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.559
ENSPREP00000018776	gja1	ENSPREP00000018776	ENSPREP00000000836	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.458
LOC103470513	chrd	ENSPREP00000010081	ENSPREP00000014581	Metalloendopeptidase.	Chordin; Belongs to the chordin family.	0.849
chrd	LOC103470513	ENSPREP00000014581	ENSPREP00000010081	Chordin; Belongs to the chordin family.	Metalloendopeptidase.	0.849
chrd	tll1	ENSPREP00000014581	ENSPREP00000000107	Chordin; Belongs to the chordin family.	Metalloendopeptidase.	0.849
dlx5	dlx6	ENSPREP00000002911	ENSPREP00000002931	Distal-less homeobox 5a.	Distal-less homeobox 6a.	0.838
dlx6	dlx5	ENSPREP00000002931	ENSPREP00000002911	Distal-less homeobox 6a.	Distal-less homeobox 5a.	0.838
gja1	CDH2	ENSPREP00000000836	ENSPREP00000007079	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	0.559
gja1	ENSPREP00000018776	ENSPREP00000000836	ENSPREP00000018776	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.458
tll1	chrd	ENSPREP00000000107	ENSPREP00000014581	Metalloendopeptidase.	Chordin; Belongs to the chordin family.	0.849