60 items (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	polh	Polymerase (DNA directed), eta. (716 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1357 aa)
	Cops9	COP9 signalosome subunit 9. (78 aa)
	LOC103467285	Mitogen-activated protein kinase. (347 aa)
	rhno1	Si:ch73-352p4.5. (221 aa)
	cul4a	Cullin 4A; Belongs to the cullin family. (591 aa)
	LOC103482005	E1A binding protein p300 a. (2743 aa)
	bmf	Uncharacterized protein. (160 aa)
	impact	Impact RWD domain protein. (320 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1652 aa)
	opn5	Opsin 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
	rhbdd1	Rhomboid domain containing 1. (312 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (298 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
	LOC103468460	E1A binding protein p300 b. (2737 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (478 aa)
	LOC103457850	Opsin 8, group member b; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (345 aa)
	ercc4	Excision repair cross-complementation group 4. (893 aa)
	LOC103482089	Fibrinogen C-terminal domain-containing protein. (244 aa)
	MFAP4	Microfibril associated protein 4. (252 aa)
	noc2l	NOC2-like nucleolar associated transcriptional repressor. (556 aa)
	LOC103473809	Fibrinogen C-terminal domain-containing protein. (239 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (602 aa)
	LOC103471497	Aurora kinase B; Belongs to the protein kinase superfamily. (350 aa)
	pold1	DNA polymerase. (1102 aa)
	ino80	INO80 complex ATPase subunit. (1484 aa)
	casp9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (427 aa)
	xpc	Xeroderma pigmentosum, complementation group C. (852 aa)
	zbtb1	Zinc finger and BTB domain containing 1. (681 aa)
	cul4b	Cullin 4B; Belongs to the cullin family. (872 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2589 aa)
	LOC103481692	Fibrinogen C-terminal domain-containing protein. (245 aa)
	LOC103480536	Methyltransferase like 3; Belongs to the MT-A70-like family. (287 aa)
	ercc1	Excision repair cross-complementation group 1. (358 aa)
	BAX	BCL2 associated X, apoptosis regulator. (191 aa)
	eif2s1	Eukaryotic translation initiation factor 2, subunit 1 alpha b. (310 aa)
	ppid	Peptidylprolyl isomerase D. (373 aa)
	crebbp	CREB binding protein b. (2452 aa)
	ENSPREP00000010780	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (176 aa)
	aqp1	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
	tmem161a	Transmembrane protein 161A. (496 aa)
	ENSPREP00000007854	Uncharacterized protein. (143 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (855 aa)
	ddb1	Damage-specific DNA binding protein 1. (1102 aa)
	polk	Polymerase (DNA directed) kappa. (880 aa)
	LOC103461212	Fibrinogen C-terminal domain-containing protein. (241 aa)
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1057 aa)
	opn3	Opsin 3. (490 aa)
	sirt1	Sirtuin 1. (677 aa)
	mc1r	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (314 aa)
	LOC103464907	Mitogen-activated protein kinase. (363 aa)
	LOC103466877	Mitogen-activated protein kinase. (364 aa)
	LOC103462295	Zgc:153993. (263 aa)
	actr5	Actin related protein 5; Belongs to the actin family. (624 aa)
	Nfatc4	Uncharacterized protein. (238 aa)
	ENSPREP00000001630	RHD domain-containing protein. (238 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
	LOC103464091	CREB binding protein a. (2371 aa)
	xpa	Xeroderma pigmentosum, complementation group A. (275 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAX	LOC103462295	ENSPREP00000013021	ENSPREP00000002464	BCL2 associated X, apoptosis regulator.	Zgc:153993.	0.988
BAX	bmf	ENSPREP00000013021	ENSPREP00000030451	BCL2 associated X, apoptosis regulator.	Uncharacterized protein.	0.527
BAX	casp9	ENSPREP00000013021	ENSPREP00000019950	BCL2 associated X, apoptosis regulator.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.499
EIF2AK4	eif2s1	ENSPREP00000030055	ENSPREP00000012662	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2, subunit 1 alpha b.	0.995
EIF2AK4	impact	ENSPREP00000030055	ENSPREP00000030368	Eukaryotic translation initiation factor 2 alpha kinase 4.	Impact RWD domain protein.	0.494
EIF2AK4	sirt1	ENSPREP00000030055	ENSPREP00000003960	Eukaryotic translation initiation factor 2 alpha kinase 4.	Sirtuin 1.	0.401
ENSPREP00000001630	Nfatc4	ENSPREP00000001630	ENSPREP00000001665	RHD domain-containing protein.	Uncharacterized protein.	0.865
ENSPREP00000001630	pold1	ENSPREP00000001630	ENSPREP00000020414	RHD domain-containing protein.	DNA polymerase.	0.471
ENSPREP00000007854	LOC103480536	ENSPREP00000007854	ENSPREP00000015801	Uncharacterized protein.	Methyltransferase like 3; Belongs to the MT-A70-like family.	0.899
LOC103457850	opn3	ENSPREP00000024988	ENSPREP00000004166	Opsin 8, group member b; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	Opsin 3.	0.470
LOC103462295	BAX	ENSPREP00000002464	ENSPREP00000013021	Zgc:153993.	BCL2 associated X, apoptosis regulator.	0.988
LOC103462295	bmf	ENSPREP00000002464	ENSPREP00000030451	Zgc:153993.	Uncharacterized protein.	0.623
LOC103462295	casp9	ENSPREP00000002464	ENSPREP00000019950	Zgc:153993.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.499
LOC103464091	LOC103468460	ENSPREP00000000408	ENSPREP00000026558	CREB binding protein a.	E1A binding protein p300 b.	0.928
LOC103464091	LOC103482005	ENSPREP00000000408	ENSPREP00000030842	CREB binding protein a.	E1A binding protein p300 a.	0.928
LOC103464091	kdm1a	ENSPREP00000000408	ENSPREP00000006670	CREB binding protein a.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.534
LOC103464091	sirt1	ENSPREP00000000408	ENSPREP00000003960	CREB binding protein a.	Sirtuin 1.	0.594
LOC103464091	xpa	ENSPREP00000000408	ENSPREP00000000357	CREB binding protein a.	Xeroderma pigmentosum, complementation group A.	0.760
LOC103468460	LOC103464091	ENSPREP00000026558	ENSPREP00000000408	E1A binding protein p300 b.	CREB binding protein a.	0.928
LOC103468460	LOC103482005	ENSPREP00000026558	ENSPREP00000030842	E1A binding protein p300 b.	E1A binding protein p300 a.	0.902