(40 nodes) Embryonic hemopoiesis network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103477731	Activating transcription factor 4a. (424 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
	LOC103462977	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
	gja1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (387 aa)
	Tal1	BHLH domain-containing protein. (124 aa)
	hdac9	Histone deacetylase 9b. (631 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1502 aa)
	ENSPREP00000003831	Uncharacterized protein. (102 aa)
	hhex	Homeobox domain-containing protein. (296 aa)
	phykpl	5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (437 aa)
	myct1	Myc target 1a. (196 aa)
	slc40a1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (566 aa)
	LOC103470499	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family. (338 aa)
	LOC103469320	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (608 aa)
	LOC103470513	Metalloendopeptidase. (970 aa)
	lclat1	Lysocardiolipin acyltransferase 1. (376 aa)
	ism1	Isthmin 1. (505 aa)
	LOC103478059	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
	nop10	NOP10 ribonucleoprotein homolog (yeast). (64 aa)
	trim33	Tripartite motif containing 33. (1223 aa)
	chrd	Chordin; Belongs to the chordin family. (949 aa)
	tgfbr2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
	LOC103460214	Uncharacterized protein. (269 aa)
	tll1	Metalloendopeptidase. (1027 aa)
	sh2b3	SH2B adaptor protein 3. (710 aa)
	yap1	Yes-associated protein 1. (433 aa)
	ENSPREP00000022294	Bmi1 polycomb ring finger oncogene 1a. (345 aa)
	rps24	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family. (139 aa)
	lmo2	LIM domain only 2 (rhombotin-like 1). (160 aa)
	ccdc134	Si:dkey-167k11.5. (246 aa)
	LOC103479412	T-cell acute lymphocytic leukemia 1. (394 aa)
	TGFBR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (544 aa)
	ncoa2	Nuclear receptor coactivator 2. (1521 aa)
	ENSPREP00000027951	Uncharacterized protein. (379 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (683 aa)
	etnppl	Ethanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (460 aa)
	ENSPREP00000029241	Preseq_ALAS domain-containing protein. (191 aa)
	tbx20	T-box transcription factor 20. (440 aa)
	LOC103465552	GATA binding protein 1a. (426 aa)
	LOC103468004	5-aminolevulinate synthase. (615 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000029241	LOC103465552	ENSPREP00000029241	ENSPREP00000032805	Preseq_ALAS domain-containing protein.	GATA binding protein 1a.	0.414
ENSPREP00000029241	LOC103470499	ENSPREP00000029241	ENSPREP00000009377	Preseq_ALAS domain-containing protein.	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.403
LOC103460214	LOC103479412	ENSPREP00000017910	ENSPREP00000025934	Uncharacterized protein.	T-cell acute lymphocytic leukemia 1.	0.740
LOC103460214	Tal1	ENSPREP00000017910	ENSPREP00000001256	Uncharacterized protein.	BHLH domain-containing protein.	0.740
LOC103460214	lmo2	ENSPREP00000017910	ENSPREP00000024054	Uncharacterized protein.	LIM domain only 2 (rhombotin-like 1).	0.933
LOC103462977	PRKCA	ENSPREP00000000513	ENSPREP00000000304	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.901
LOC103462977	PRKCB	ENSPREP00000000513	ENSPREP00000028542	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.900
LOC103465552	ENSPREP00000029241	ENSPREP00000032805	ENSPREP00000029241	GATA binding protein 1a.	Preseq_ALAS domain-containing protein.	0.414
LOC103465552	LOC103468004	ENSPREP00000032805	ENSPREP00000033646	GATA binding protein 1a.	5-aminolevulinate synthase.	0.414
LOC103465552	LOC103479412	ENSPREP00000032805	ENSPREP00000025934	GATA binding protein 1a.	T-cell acute lymphocytic leukemia 1.	0.740
LOC103465552	Tal1	ENSPREP00000032805	ENSPREP00000001256	GATA binding protein 1a.	BHLH domain-containing protein.	0.740
LOC103465552	lmo2	ENSPREP00000032805	ENSPREP00000024054	GATA binding protein 1a.	LIM domain only 2 (rhombotin-like 1).	0.933
LOC103468004	LOC103465552	ENSPREP00000033646	ENSPREP00000032805	5-aminolevulinate synthase.	GATA binding protein 1a.	0.414
LOC103468004	LOC103470499	ENSPREP00000033646	ENSPREP00000009377	5-aminolevulinate synthase.	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.403
LOC103470499	ENSPREP00000029241	ENSPREP00000009377	ENSPREP00000029241	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Preseq_ALAS domain-containing protein.	0.403
LOC103470499	LOC103468004	ENSPREP00000009377	ENSPREP00000033646	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	5-aminolevulinate synthase.	0.403
LOC103470499	slc40a1	ENSPREP00000009377	ENSPREP00000008949	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.	0.440
LOC103470513	chrd	ENSPREP00000010081	ENSPREP00000014581	Metalloendopeptidase.	Chordin; Belongs to the chordin family.	0.849
LOC103470513	yap1	ENSPREP00000010081	ENSPREP00000022087	Metalloendopeptidase.	Yes-associated protein 1.	0.414
LOC103479412	LOC103460214	ENSPREP00000025934	ENSPREP00000017910	T-cell acute lymphocytic leukemia 1.	Uncharacterized protein.	0.740