(29 nodes) CD4-positive, alpha-beta T cell activation network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ptger4	Prostaglandin E receptor 4 (subtype EP4) b. (456 aa)
	LOC103470093	Homeobox domain-containing protein. (363 aa)
	batf	Basic leucine zipper transcription factor, ATF-like. (124 aa)
	nkx2-3	NK2 homeobox 3. (349 aa)
	stoml2	Stomatin (EPB72)-like 2. (351 aa)
	LOC103479168	Si:ch211-184m13.4; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	gpr183	G protein-coupled receptor 183a; Belongs to the G-protein coupled receptor 1 family. (386 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (582 aa)
	snx12	Fibronectin type-III domain-containing protein. (355 aa)
	ENSPREP00000011587	Uncharacterized protein. (331 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (522 aa)
	ENSPREP00000012469	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (487 aa)
	rc3h2	Ring finger and CCCH-type domains 2. (1110 aa)
	tmem98	Transmembrane protein 98. (224 aa)
	armc5	Armadillo repeat containing 5. (841 aa)
	ENSPREP00000016378	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (702 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1001 aa)
	itch	E3 ubiquitin-protein ligase. (840 aa)
	sash3	SAM and SH3 domain containing 3. (397 aa)
	tbx21	T-box transcription factor 21. (614 aa)
	ENSPREP00000022389	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (424 aa)
	LOC103464828	E3 ubiquitin-protein ligase. (869 aa)
	LOC103478148	Interleukin 6 receptor. (603 aa)
	rc3h1	Ring finger and CCCH-type domains 1b. (1119 aa)
	cd83	CD83 molecule. (228 aa)
	ENSPREP00000027430	CARD domain-containing protein. (524 aa)
	LOC103468544	Guanylate kinase-like domain-containing protein. (308 aa)
	lef1	Lymphoid enhancer-binding factor 1. (422 aa)
	ENSPREP00000005271	Uncharacterized protein. (210 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000016378	Mtor	ENSPREP00000016378	ENSPREP00000016474	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.934
ENSPREP00000027430	LOC103468544	ENSPREP00000027430	ENSPREP00000027446	CARD domain-containing protein.	Guanylate kinase-like domain-containing protein.	0.900
ENSPREP00000027430	ripk2	ENSPREP00000027430	ENSPREP00000009886	CARD domain-containing protein.	Receptor-interacting serine-threonine kinase 2.	0.489
LOC103464828	itch	ENSPREP00000023584	ENSPREP00000001984	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.901
LOC103464828	ripk2	ENSPREP00000023584	ENSPREP00000009886	E3 ubiquitin-protein ligase.	Receptor-interacting serine-threonine kinase 2.	0.573
LOC103468544	ENSPREP00000027430	ENSPREP00000027446	ENSPREP00000027430	Guanylate kinase-like domain-containing protein.	CARD domain-containing protein.	0.900
LOC103468544	ripk2	ENSPREP00000027446	ENSPREP00000009886	Guanylate kinase-like domain-containing protein.	Receptor-interacting serine-threonine kinase 2.	0.489
Mtor	ENSPREP00000016378	ENSPREP00000016474	ENSPREP00000016378	Serine/threonine-protein kinase TOR.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.934
hlx	tbx21	ENSPREP00000011978	ENSPREP00000019011	H2.0-like homeo box 1 (Drosophila).	T-box transcription factor 21.	0.553
itch	LOC103464828	ENSPREP00000001984	ENSPREP00000023584	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.901
itch	ripk2	ENSPREP00000001984	ENSPREP00000009886	E3 ubiquitin-protein ligase.	Receptor-interacting serine-threonine kinase 2.	0.573
rc3h1	rc3h2	ENSPREP00000025906	ENSPREP00000013221	Ring finger and CCCH-type domains 1b.	Ring finger and CCCH-type domains 2.	0.672
rc3h2	rc3h1	ENSPREP00000013221	ENSPREP00000025906	Ring finger and CCCH-type domains 2.	Ring finger and CCCH-type domains 1b.	0.672
ripk2	ENSPREP00000027430	ENSPREP00000009886	ENSPREP00000027430	Receptor-interacting serine-threonine kinase 2.	CARD domain-containing protein.	0.489
ripk2	LOC103464828	ENSPREP00000009886	ENSPREP00000023584	Receptor-interacting serine-threonine kinase 2.	E3 ubiquitin-protein ligase.	0.573
ripk2	LOC103468544	ENSPREP00000009886	ENSPREP00000027446	Receptor-interacting serine-threonine kinase 2.	Guanylate kinase-like domain-containing protein.	0.489
ripk2	itch	ENSPREP00000009886	ENSPREP00000001984	Receptor-interacting serine-threonine kinase 2.	E3 ubiquitin-protein ligase.	0.573
tbx21	hlx	ENSPREP00000019011	ENSPREP00000011978	T-box transcription factor 21.	H2.0-like homeo box 1 (Drosophila).	0.553