(63 nodes) Tissue regeneration network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (865 aa)
	LOC103481539	SIX homeobox 3b. (277 aa)
	LOC103466952	Uncharacterized protein. (163 aa)
	LOC103466662	Tetraspanin. (237 aa)
	LOC103479222	Kruppel-like factor 5b. (437 aa)
	akirin1	Akirin 1. (186 aa)
	bin3	Bridging integrator 3. (248 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	LOC103481573	Family with sequence similarity 53 member B. (393 aa)
	ascl1	Achaete-scute family bHLH transcription factor 1a. (200 aa)
	gap43	Growth associated protein 43. (237 aa)
	igf1	Insulin-like growth factor 1. (186 aa)
	LOC103473609	POU domain protein. (513 aa)
	LOC103465116	Ninjurin 1. (142 aa)
	axin1	Axin 1. (850 aa)
	lfng	Beta-1,3-N-acetylglucosaminyltransferase. (367 aa)
	tmem182	Transmembrane protein 182a. (246 aa)
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (770 aa)
	CPQ	Carboxypeptidase Q. (461 aa)
	ENSPREP00000014132	Uncharacterized protein. (138 aa)
	ENSPREP00000014253	Uncharacterized protein. (149 aa)
	LOC103464644	Si:dkey-49n23.1; Belongs to the semaphorin family. (731 aa)
	CCN3	Cellular communication network factor 3. (349 aa)
	ifrd1	Interferon-related developmental regulator 1. (428 aa)
	ezh2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (762 aa)
	klf5	Progesterone immunomodulatory binding factor 1. (566 aa)
	FAM53B	Family with sequence similarity 53 member B. (438 aa)
	ptgfrn	Uncharacterized protein. (857 aa)
	ENSPREP00000018776	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (824 aa)
	LOC103476345	Kruppel-like factor 5 like. (390 aa)
	LOC103479802	Apolipoprotein Da, duplicate 1; Belongs to the calycin superfamily. Lipocalin family. (186 aa)
	sema3d	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; Belongs to the semaphorin family. (794 aa)
	gdf11	Growth differentiation factor 11. (388 aa)
	LOC103473796	T-box transcription factor 5a. (524 aa)
	yap1	Yes-associated protein 1. (433 aa)
	ttk	Ttk protein kinase. (996 aa)
	six6	SIX homeobox 6a. (245 aa)
	lmo2	LIM domain only 2 (rhombotin-like 1). (160 aa)
	LOC103473596	Transmembrane protein 182b. (260 aa)
	esco2	Establishment of sister chromatid cohesion N-acetyltransferase 2. (528 aa)
	ENSPREP00000025759	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	gata3	GATA binding protein 3. (483 aa)
	LOC103467447	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	larp7	La ribonucleoprotein domain family, member 7. (560 aa)
	LGR6	Leucine rich repeat containing G protein-coupled receptor 6. (938 aa)
	ENSPREP00000031443	Uncharacterized protein. (175 aa)
	CD9	Tetraspanin. (210 aa)
	LOC103470930	Uncharacterized protein. (250 aa)
	rbbp4	Retinoblastoma binding protein 4. (424 aa)
	RBBP7	RB binding protein 7, chromatin remodeling factor. (422 aa)
	ptn	Pleiotrophin. (161 aa)
	tm4sf4	Transmembrane 4 L six family member 4. (226 aa)
	LOC103456761	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family. (182 aa)
	LOC103459284	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	ENSPREP00000006590	Si:ch73-390p7.2. (123 aa)
	LOC103459309	Ninjurin 2. (161 aa)
	LOC103473526	Interferon-related developmental regulator 2. (455 aa)
	Six3	SIX homeobox 3a. (341 aa)
	LOC103475931	SIX homeobox 7. (260 aa)
	LOC103469672	Fibroblast growth factor receptor. (831 aa)
	gja1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (387 aa)
	LOC103456513	Uncharacterized protein. (883 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD9	ptgfrn	ENSPREP00000031884	ENSPREP00000018066	Tetraspanin.	Uncharacterized protein.	0.802
CDH2	gja1	ENSPREP00000007079	ENSPREP00000000836	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.559
ENSPREP00000014132	RBBP7	ENSPREP00000014132	ENSPREP00000032935	Uncharacterized protein.	RB binding protein 7, chromatin remodeling factor.	0.870
ENSPREP00000014132	rbbp4	ENSPREP00000014132	ENSPREP00000032501	Uncharacterized protein.	Retinoblastoma binding protein 4.	0.870
ENSPREP00000018776	gja1	ENSPREP00000018776	ENSPREP00000000836	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.458
ENSPREP00000025759	LOC103456513	ENSPREP00000025759	ENSPREP00000000160	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein.	0.530
ENSPREP00000025759	axin1	ENSPREP00000025759	ENSPREP00000012177	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Axin 1.	0.530
EZH1	RBBP7	ENSPREP00000013900	ENSPREP00000032935	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	RB binding protein 7, chromatin remodeling factor.	0.870
EZH1	rbbp4	ENSPREP00000013900	ENSPREP00000032501	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Retinoblastoma binding protein 4.	0.870
LOC103456513	ENSPREP00000025759	ENSPREP00000000160	ENSPREP00000025759	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.530
LOC103456513	axin1	ENSPREP00000000160	ENSPREP00000012177	Uncharacterized protein.	Axin 1.	0.902
LOC103459284	LOC103467447	ENSPREP00000006858	ENSPREP00000028159	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901
LOC103459284	wnt4	ENSPREP00000006858	ENSPREP00000026620	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.613
LOC103459309	gap43	ENSPREP00000006512	ENSPREP00000010231	Ninjurin 2.	Growth associated protein 43.	0.463
LOC103459309	gja1	ENSPREP00000006512	ENSPREP00000000836	Ninjurin 2.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.439
LOC103459309	ptn	ENSPREP00000006512	ENSPREP00000032939	Ninjurin 2.	Pleiotrophin.	0.590
LOC103466662	ptgfrn	ENSPREP00000008818	ENSPREP00000018066	Tetraspanin.	Uncharacterized protein.	0.802
LOC103467447	LOC103459284	ENSPREP00000028159	ENSPREP00000006858	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901
LOC103467447	wnt4	ENSPREP00000028159	ENSPREP00000026620	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.618
LOC103469672	fgf2	ENSPREP00000001007	ENSPREP00000009634	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.878