(44 nodes) Ribosome assembly network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (731 aa)
	dhx30	DEAH (Asp-Glu-Ala-His) box helicase 30. (1083 aa)
	fastkd2	FAST kinase domains 2. (612 aa)
	nop2	NOP2 nucleolar protein homolog (yeast); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (688 aa)
	rpl6	Ribosomal protein L6. (259 aa)
	mpv17l2	MPV17 mitochondrial membrane protein-like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family. (218 aa)
	dhx37	DEAH (Asp-Glu-Ala-His) box polypeptide 37. (1154 aa)
	nip7	NIP7 nucleolar pre-rRNA processing protein. (133 aa)
	ENSPREP00000018770	Uncharacterized protein. (73 aa)
	traf7	TNF receptor-associated factor 7. (688 aa)
	abt1	Activator of basal transcription 1. (274 aa)
	mrpl22	Mitochondrial ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family. (213 aa)
	RPL5-2	Ribosomal protein L5b. (295 aa)
	rps5	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. (245 aa)
	mrps7	Mitochondrial ribosomal protein S7. (229 aa)
	ddx28	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28. (569 aa)
	dhx29	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1373 aa)
	mrps11	Mitochondrial ribosomal protein S11; Belongs to the universal ribosomal protein uS11 family. (194 aa)
	mrpl20	Mitochondrial ribosomal protein L20; Belongs to the bacterial ribosomal protein bL20 family. (149 aa)
	rpl10	Ribosomal protein L10. (215 aa)
	mrto4	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (237 aa)
	rpsa	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Belongs to the universal ribosomal protein uS2 family. (307 aa)
	eral1	Era-like 12S mitochondrial rRNA chaperone 1. (435 aa)
	mterf3	Mitochondrial transcription termination factor 3. (423 aa)
	RPL5	Ribosomal protein L5. (298 aa)
	c1qbp	Complement component 1, q subcomponent binding protein. (289 aa)
	EFL1	Elongation factor like GTPase 1. (1106 aa)
	eif6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (255 aa)
	rpf2	Ribosome production factor 2 homolog. (305 aa)
	rrs1	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (308 aa)
	ENSPREP00000028465	40S ribosomal protein S27. (95 aa)
	sbds	SBDS ribosome maturation factor. (249 aa)
	LOC103478181	40S ribosomal protein S27. (124 aa)
	brix1	Brix domain containing 2. (374 aa)
	rpl23a	Ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family. (163 aa)
	LOC103479383	Uncharacterized protein. (341 aa)
	rrp7a	Ribosomal RNA processing 7 homolog A. (306 aa)
	LOC103473717	PWP2 small subunit processome component. (914 aa)
	nle1	Notchless homolog 1 (Drosophila). (478 aa)
	Ngrn	Uncharacterized protein. (296 aa)
	ENSPREP00000021034	Uncharacterized protein. (125 aa)
	mrm2	Mitochondrial rRNA methyltransferase 2. (203 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (431 aa)
	prkdc	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3907 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EFL1	ENSPREP00000018770	ENSPREP00000032600	ENSPREP00000018770	Elongation factor like GTPase 1.	Uncharacterized protein.	0.544
EFL1	ENSPREP00000021034	ENSPREP00000032600	ENSPREP00000021034	Elongation factor like GTPase 1.	Uncharacterized protein.	0.778
EFL1	ENSPREP00000028465	ENSPREP00000032600	ENSPREP00000028465	Elongation factor like GTPase 1.	40S ribosomal protein S27.	0.544
EFL1	LOC103478181	ENSPREP00000032600	ENSPREP00000025940	Elongation factor like GTPase 1.	40S ribosomal protein S27.	0.544
EFL1	RPL5	ENSPREP00000032600	ENSPREP00000011806	Elongation factor like GTPase 1.	Ribosomal protein L5.	0.860
EFL1	RPL5-2	ENSPREP00000032600	ENSPREP00000020679	Elongation factor like GTPase 1.	Ribosomal protein L5b.	0.860
EFL1	ddx28	ENSPREP00000032600	ENSPREP00000004087	Elongation factor like GTPase 1.	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28.	0.465
EFL1	eif6	ENSPREP00000032600	ENSPREP00000032039	Elongation factor like GTPase 1.	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	0.840
EFL1	mrpl20	ENSPREP00000032600	ENSPREP00000007157	Elongation factor like GTPase 1.	Mitochondrial ribosomal protein L20; Belongs to the bacterial ribosomal protein bL20 family.	0.902
EFL1	mrpl22	ENSPREP00000032600	ENSPREP00000019575	Elongation factor like GTPase 1.	Mitochondrial ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	0.860
EFL1	mrps11	ENSPREP00000032600	ENSPREP00000006904	Elongation factor like GTPase 1.	Mitochondrial ribosomal protein S11; Belongs to the universal ribosomal protein uS11 family.	0.813
EFL1	mrps7	ENSPREP00000032600	ENSPREP00000003196	Elongation factor like GTPase 1.	Mitochondrial ribosomal protein S7.	0.861
EFL1	mrto4	ENSPREP00000032600	ENSPREP00000009164	Elongation factor like GTPase 1.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.893
EFL1	rpl10	ENSPREP00000032600	ENSPREP00000008896	Elongation factor like GTPase 1.	Ribosomal protein L10.	0.853
EFL1	rpl23a	ENSPREP00000032600	ENSPREP00000025041	Elongation factor like GTPase 1.	Ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family.	0.929
EFL1	rpl6	ENSPREP00000032600	ENSPREP00000016862	Elongation factor like GTPase 1.	Ribosomal protein L6.	0.676
EFL1	rps5	ENSPREP00000032600	ENSPREP00000002609	Elongation factor like GTPase 1.	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family.	0.869
EFL1	rpsa	ENSPREP00000032600	ENSPREP00000021005	Elongation factor like GTPase 1.	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Belongs to the universal ribosomal protein uS2 family.	0.778
EFL1	sbds	ENSPREP00000032600	ENSPREP00000027723	Elongation factor like GTPase 1.	SBDS ribosome maturation factor.	0.967
ENSPREP00000018770	EFL1	ENSPREP00000018770	ENSPREP00000032600	Uncharacterized protein.	Elongation factor like GTPase 1.	0.544