(82 nodes) Melanosome network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cltcl1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1696 aa)
	NCSTN	Nicastrin. (699 aa)
	ENSPREP00000001350	Uncharacterized protein. (93 aa)
	rab27a	RAB27A, member RAS oncogene family. (163 aa)
	LOC103456937	Carrier domain-containing protein. (2076 aa)
	LOC103456785	Si:dkey-61p9.11. (2009 aa)
	gpr143	G protein-coupled receptor 143. (450 aa)
	gpnmb	Glycoprotein (transmembrane) nmb. (624 aa)
	dct	Dopachrome tautomerase. (528 aa)
	rab32	RAB32a, member RAS oncogene family. (223 aa)
	LOC103458108	Solute carrier family 3 member 2b. (567 aa)
	LOC103474743	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1685 aa)
	LOC103477863	RAB5A, member RAS oncogene family, b. (216 aa)
	fasn	Coiled-coil domain containing 57. (2516 aa)
	hsp90b1	Heat shock protein 90, beta (grp94), member 1. (721 aa)
	LOC103466685	Calumenin b. (315 aa)
	sytl1	Synaptotagmin-like 1. (532 aa)
	LOC103460653	Si:dkey-16l2.16. (209 aa)
	pdcd6ip	Programmed cell death 6 interacting protein. (878 aa)
	ENSPREP00000008622	Protein disulfide isomerase family A, member 3. (335 aa)
	anxa6	Annexin. (665 aa)
	ENSPREP00000009603	RAB5A, member RAS oncogene family, a. (57 aa)
	pdia6	Protein disulfide isomerase family A, member 6; Belongs to the protein disulfide isomerase family. (432 aa)
	LOC103479084	SEC22 homolog B, vesicle trafficking protein a; Belongs to the synaptobrevin family. (215 aa)
	tmem33	Transmembrane protein 33. (248 aa)
	LOC103475390	RAB38c, member of RAS oncogene family. (260 aa)
	LOC103461591	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (133 aa)
	LOC103469909	Uncharacterized protein. (227 aa)
	dtnbp1	Dystrobrevin binding protein 1b. (229 aa)
	cltc	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1700 aa)
	ywhae	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1; Belongs to the 14-3-3 family. (255 aa)
	LOC103463624	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (220 aa)
	LOC103480388	Zgc:162171. (251 aa)
	LOC103477313	Solute carrier family 1 member 4. (549 aa)
	abcb6	ATP-binding cassette, sub-family B (MDR/TAP), member 6a. (863 aa)
	rab5c	RAB5C, member RAS oncogene family. (220 aa)
	mfsd12	Major facilitator superfamily domain containing 12a. (480 aa)
	LOC103462835	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (193 aa)
	CNP	2',3'-cyclic nucleotide 3' phosphodiesterase. (653 aa)
	LOC103469120	Tyrosinase-related protein 1b. (549 aa)
	ENSPREP00000001090	Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family. (180 aa)
	slc24a5	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (423 aa)
	LOC103469428	Zgc:91968. (235 aa)
	LOC103474215	Synaptotagmin-like 2b. (1682 aa)
	RAB7A	RAB7A, member RAS oncogene family. (207 aa)
	LOC103475527	RAB38b, member of RAS oncogene family. (218 aa)
	TYR	Tyrosinase. (542 aa)
	ppib	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
	capg	Capping protein (actin filament), gelsolin-like b. (344 aa)
	LOC103457917	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1. (767 aa)
	HSP90AA1	Heat shock protein 90 alpha family class A member 1. (496 aa)
	pmel	Premelanosome protein a. (808 aa)
	LOC103470103	Folate gamma-glutamyl hydrolase. (298 aa)
	pdia4	Protein disulfide-isomerase A4; Belongs to the protein disulfide isomerase family. (639 aa)
	rab35	RAB35, member RAS oncogene family b. (184 aa)
	ganab	Glucosidase, alpha; neutral AB; Belongs to the glycosyl hydrolase 31 family. (952 aa)
	LOC103460482	Uncharacterized protein. (222 aa)
	hspa5	Heat shock protein 5; Belongs to the heat shock protein 70 family. (652 aa)
	LOC103460379	Gelsolin b. (738 aa)
	oca2	Oculocutaneous albinism II. (840 aa)
	LOC103465062	RAB7a, member RAS oncogene family. (207 aa)
	LOC103478790	Uncharacterized protein. (337 aa)
	Ankrd27	Uncharacterized protein. (77 aa)
	tyrp1	Tyrosinase related protein 1. (525 aa)
	LOC103467913	Premelanosome protein b. (610 aa)
	calu	Uncharacterized protein. (316 aa)
	slc3a2	Aamy domain-containing protein. (492 aa)
	LOC103481860	RAB5B, member RAS oncogene family. (216 aa)
	RAB27B	RAB27B, member RAS oncogene family. (218 aa)
	ctsb	Cathepsin Bb; Belongs to the peptidase C1 family. (324 aa)
	ctns	Cystinosin, lysosomal cystine transporter. (419 aa)
	hps4	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. (616 aa)
	tyr	Tyrosinase. (545 aa)
	RAB38	RAB38, member RAS oncogene family. (212 aa)
	ahcy	Adenosylhomocysteinase. (358 aa)
	lamp1	Lysosomal associated membrane protein 1a. (409 aa)
	LOC103473971	Gelsolin a. (479 aa)
	ENSPREP00000032505	Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase). (247 aa)
	LOC103481258	Uncharacterized protein. (228 aa)
	LOC103464304	Folate gamma-glutamyl hydrolase. (319 aa)
	slc1a5	Amino acid transporter. (536 aa)
	LOC103474630	Si:dkey-202g17.3. (478 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ankrd27	ENSPREP00000009603	ENSPREP00000027051	ENSPREP00000009603	Uncharacterized protein.	RAB5A, member RAS oncogene family, a.	0.556
Ankrd27	LOC103475390	ENSPREP00000027051	ENSPREP00000010477	Uncharacterized protein.	RAB38c, member of RAS oncogene family.	0.573
Ankrd27	LOC103475527	ENSPREP00000027051	ENSPREP00000019156	Uncharacterized protein.	RAB38b, member of RAS oncogene family.	0.573
Ankrd27	LOC103477863	ENSPREP00000027051	ENSPREP00000005592	Uncharacterized protein.	RAB5A, member RAS oncogene family, b.	0.556
Ankrd27	LOC103480388	ENSPREP00000027051	ENSPREP00000014129	Uncharacterized protein.	Zgc:162171.	0.573
Ankrd27	LOC103481258	ENSPREP00000027051	ENSPREP00000032734	Uncharacterized protein.	Uncharacterized protein.	0.556
Ankrd27	LOC103481860	ENSPREP00000027051	ENSPREP00000029753	Uncharacterized protein.	RAB5B, member RAS oncogene family.	0.556
Ankrd27	RAB38	ENSPREP00000027051	ENSPREP00000030455	Uncharacterized protein.	RAB38, member RAS oncogene family.	0.573
Ankrd27	rab32	ENSPREP00000027051	ENSPREP00000003785	Uncharacterized protein.	RAB32a, member RAS oncogene family.	0.573
Ankrd27	rab5c	ENSPREP00000027051	ENSPREP00000015017	Uncharacterized protein.	RAB5C, member RAS oncogene family.	0.556
ENSPREP00000001090	ENSPREP00000001350	ENSPREP00000001090	ENSPREP00000001350	Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family.	Uncharacterized protein.	0.584
ENSPREP00000001090	LOC103469909	ENSPREP00000001090	ENSPREP00000011273	Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family.	Uncharacterized protein.	0.553
ENSPREP00000001090	RAB27B	ENSPREP00000001090	ENSPREP00000029842	Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family.	RAB27B, member RAS oncogene family.	0.553
ENSPREP00000001090	anxa6	ENSPREP00000001090	ENSPREP00000008911	Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family.	Annexin.	0.410
ENSPREP00000001090	lamp1	ENSPREP00000001090	ENSPREP00000031762	Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family.	Lysosomal associated membrane protein 1a.	0.707
ENSPREP00000001090	pdcd6ip	ENSPREP00000001090	ENSPREP00000007944	Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family.	Programmed cell death 6 interacting protein.	0.549
ENSPREP00000001090	pmel	ENSPREP00000001090	ENSPREP00000021188	Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family.	Premelanosome protein a.	0.461
ENSPREP00000001090	rab27a	ENSPREP00000001090	ENSPREP00000001371	Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family.	RAB27A, member RAS oncogene family.	0.584
ENSPREP00000001350	ENSPREP00000001090	ENSPREP00000001350	ENSPREP00000001090	Uncharacterized protein.	Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family.	0.584
ENSPREP00000001350	LOC103474215	ENSPREP00000001350	ENSPREP00000017023	Uncharacterized protein.	Synaptotagmin-like 2b.	0.530