(30 nodes) Regulation of vascular permeability network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103472916	Dimethylarginine dimethylaminohydrolase 2. (265 aa)
	ENSPREP00000005814	A kinase (PRKA) anchor protein 12b. (1314 aa)
	LOC103477848	Apolipoprotein Eb. (265 aa)
	tjp2	Tight junction protein 2a (zona occludens 2); Belongs to the MAGUK family. (1077 aa)
	tjp3	Tight junction protein 3; Belongs to the MAGUK family. (1306 aa)
	LOC103476642	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (725 aa)
	LOC103479149	Uncharacterized protein. (678 aa)
	LOC103466593	C2 calcium dependent domain containing 4A. (448 aa)
	LOC103463647	Forkhead box Q2. (289 aa)
	LOC103460866	G_PROTEIN_RECEP_F1_2 domain-containing protein. (272 aa)
	LOC103469388	Receptor (G protein-coupled) activity modifying protein 2. (202 aa)
	LOC103478402	TYR_PHOSPHATASE_2 domain-containing protein. (173 aa)
	FOXC1	Forkhead box C1. (471 aa)
	ENSPREP00000014932	Forkhead box C1. (275 aa)
	pitx2	Homeobox protein. (312 aa)
	SRC	Tyrosine-protein kinase. (569 aa)
	Cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (142 aa)
	C2CD4C	C2 calcium dependent domain containing 4C. (419 aa)
	LOC103463294	Plasmalemma vesicle associated protein b. (460 aa)
	LOC103479269	C2 domain-containing protein. (427 aa)
	LOC103473180	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	LOC103466442	Tight junction protein 1b; Belongs to the MAGUK family. (1954 aa)
	ctnnbip1	Catenin, beta interacting protein 1. (81 aa)
	LOC103473229	Occludin a. (496 aa)
	ucn	Urotensin 1. (147 aa)
	LOC103475146	G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (348 aa)
	LOC103467856	Tyrosine-protein kinase. (542 aa)
	DDAH1	Dimethylarginine dimethylaminohydrolase 1. (138 aa)
	LOC103462420	Tight junction protein 1a; Belongs to the MAGUK family. (1693 aa)
	fgfbp3	Fibroblast growth factor binding protein 3. (237 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cldn5	LOC103462420	ENSPREP00000017247	ENSPREP00000033787	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tight junction protein 1a; Belongs to the MAGUK family.	0.790
Cldn5	LOC103466442	ENSPREP00000017247	ENSPREP00000022800	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tight junction protein 1b; Belongs to the MAGUK family.	0.790
Cldn5	LOC103473180	ENSPREP00000017247	ENSPREP00000020548	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.658
Cldn5	LOC103473229	ENSPREP00000017247	ENSPREP00000024159	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Occludin a.	0.534
Cldn5	LOC103476642	ENSPREP00000017247	ENSPREP00000010042	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.678
Cldn5	tjp2	ENSPREP00000017247	ENSPREP00000009482	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tight junction protein 2a (zona occludens 2); Belongs to the MAGUK family.	0.542
Cldn5	tjp3	ENSPREP00000017247	ENSPREP00000009851	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tight junction protein 3; Belongs to the MAGUK family.	0.783
LOC103462420	Cldn5	ENSPREP00000033787	ENSPREP00000017247	Tight junction protein 1a; Belongs to the MAGUK family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.790
LOC103462420	LOC103466442	ENSPREP00000033787	ENSPREP00000022800	Tight junction protein 1a; Belongs to the MAGUK family.	Tight junction protein 1b; Belongs to the MAGUK family.	0.902
LOC103462420	LOC103467856	ENSPREP00000033787	ENSPREP00000031006	Tight junction protein 1a; Belongs to the MAGUK family.	Tyrosine-protein kinase.	0.931
LOC103462420	LOC103473180	ENSPREP00000033787	ENSPREP00000020548	Tight junction protein 1a; Belongs to the MAGUK family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.790
LOC103462420	LOC103473229	ENSPREP00000033787	ENSPREP00000024159	Tight junction protein 1a; Belongs to the MAGUK family.	Occludin a.	0.980
LOC103462420	LOC103476642	ENSPREP00000033787	ENSPREP00000010042	Tight junction protein 1a; Belongs to the MAGUK family.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.596
LOC103462420	SRC	ENSPREP00000033787	ENSPREP00000016288	Tight junction protein 1a; Belongs to the MAGUK family.	Tyrosine-protein kinase.	0.931
LOC103462420	tjp2	ENSPREP00000033787	ENSPREP00000009482	Tight junction protein 1a; Belongs to the MAGUK family.	Tight junction protein 2a (zona occludens 2); Belongs to the MAGUK family.	0.968
LOC103462420	tjp3	ENSPREP00000033787	ENSPREP00000009851	Tight junction protein 1a; Belongs to the MAGUK family.	Tight junction protein 3; Belongs to the MAGUK family.	0.507
LOC103466442	Cldn5	ENSPREP00000022800	ENSPREP00000017247	Tight junction protein 1b; Belongs to the MAGUK family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.790
LOC103466442	LOC103462420	ENSPREP00000022800	ENSPREP00000033787	Tight junction protein 1b; Belongs to the MAGUK family.	Tight junction protein 1a; Belongs to the MAGUK family.	0.902
LOC103466442	LOC103467856	ENSPREP00000022800	ENSPREP00000031006	Tight junction protein 1b; Belongs to the MAGUK family.	Tyrosine-protein kinase.	0.931
LOC103466442	LOC103473180	ENSPREP00000022800	ENSPREP00000020548	Tight junction protein 1b; Belongs to the MAGUK family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.790