(89 nodes) Dendritic spine network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103472856	Shisa family member 7. (679 aa)
	LOC103472837	Uncharacterized protein. (196 aa)
	LOC103480164	Fragile X mental retardation, autosomal homolog 2. (656 aa)
	ppp1r9a	Protein phosphatase 1, regulatory subunit 9A. (1113 aa)
	cttnbp2	Cortactin binding protein 2. (1340 aa)
	LOC103470410	Homer scaffold protein 1b. (402 aa)
	fmr1	Fragile X mental retardation 1. (273 aa)
	LOC103468820	BAI1-associated protein 2a. (549 aa)
	SHISA6	Shisa family member 6. (571 aa)
	srgap2	SLIT-ROBO Rho GTPase activating protein 2. (1124 aa)
	eef2k	Eukaryotic elongation factor 2 kinase. (767 aa)
	CDC42	Cell division cycle 42. (191 aa)
	LOC103466333	BTB domain-containing protein; Belongs to the potassium channel family. (622 aa)
	GPM6A	Glycoprotein M6Ab. (292 aa)
	pdlim4	PDZ and LIM domain 4. (364 aa)
	LOC103458430	Protein phosphatase 1 regulatory subunit 9A-like A. (1444 aa)
	LOC103471094	Uncharacterized protein. (880 aa)
	LOC103470485	Leucine zipper, putative tumor suppressor 1. (639 aa)
	ABR	ABR activator of RhoGEF and GTPase. (1099 aa)
	ABHD17B	Abhydrolase domain containing 17B. (91 aa)
	synpo	Uncharacterized protein. (768 aa)
	LOC103474076	Amyloid beta (A4) precursor protein-binding, family A, member 1b. (1189 aa)
	atp6ap2	ATPase H+ transporting accessory protein 2. (381 aa)
	LOC103473601	BCR activator of RhoGEF and GTPase. (1374 aa)
	LOC103468699	Shisa family member 9b. (379 aa)
	LOC103468695	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	ENSPREP00000012022	Shisa family member 7a. (365 aa)
	dtnbp1	Dystrobrevin binding protein 1b. (229 aa)
	KCND3	Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (677 aa)
	LOC103463617	Abhydrolase domain containing 17A. (319 aa)
	ptk2	Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (878 aa)
	ngfr	Nerve growth factor receptor a (TNFR superfamily, member 16). (313 aa)
	LOC103481654	Protein phosphatase 1, regulatory subunit 9Bb. (813 aa)
	gpm6a	Glycoprotein M6Aa. (278 aa)
	myl7	Myosin, light chain 7, regulatory. (175 aa)
	TANC2	Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2. (2187 aa)
	shank1	SH3 and multiple ankyrin repeat domains 1. (834 aa)
	Shank1	SAM domain-containing protein. (1628 aa)
	LOC103463357	Amyloid beta precursor protein binding family A member 3. (696 aa)
	LOC103477993	Uncharacterized protein. (134 aa)
	LOC103475221	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (942 aa)
	LOC103472469	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1080 aa)
	LOC103477991	Uncharacterized protein. (191 aa)
	ENSPREP00000017519	Potassium voltage-gated channel, Shal-related subfamily, member 1; Belongs to the potassium channel family. (563 aa)
	ENSPREP00000017645	Uncharacterized protein. (191 aa)
	APBA1	Uncharacterized protein. (890 aa)
	LOC103469458	Nuclear receptor subfamily 1, group d, member 1. (523 aa)
	LOC103468315	PDZ domain-containing protein. (933 aa)
	LOC103458406	Paralemmin 1b. (225 aa)
	LOC103479270	Peptidase_S9 domain-containing protein. (359 aa)
	ENSPREP00000020142	Uncharacterized protein. (225 aa)
	ENSPREP00000020216	PDZ domain-containing protein. (88 aa)
	LOC103461746	PH domain-containing protein. (1483 aa)
	LOC103461055	Fragile X mental retardation 1. (400 aa)
	LOC103466031	SH3 and multiple ankyrin repeat domains 3a. (1984 aa)
	BAIAP2	BAI1 associated protein 2. (569 aa)
	LOC103466444	Amyloid beta (A4) precursor protein-binding, family A, member 2a. (814 aa)
	als2	Alsin Rho guanine nucleotide exchange factor ALS2 b. (1671 aa)
	LOC103463007	SH3 and multiple ankyrin repeat domains 2a. (1709 aa)
	ENSPREP00000023873	PBPe domain-containing protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (265 aa)
	ENSPREP00000023909	Lig_chan-Glu_bd domain-containing protein. (516 aa)
	Bcr	Si:dkey-91m11.5. (609 aa)
	ENSPREP00000024183	Rho-GAP domain-containing protein. (214 aa)
	shisa9	Shisa family member 9a. (563 aa)
	LOC103481054	Uncharacterized protein. (2065 aa)
	LOC103476386	Uncharacterized protein. (957 aa)
	LOC103465423	Cell division cycle 42. (191 aa)
	USP50	Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (342 aa)
	usp8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1075 aa)
	LOC103467453	Potassium voltage-gated channel, Shal-related subfamily, member 3; Belongs to the potassium channel family. (645 aa)
	kcnd2	Potassium voltage-gated channel, Shal-related subfamily, member 2; Belongs to the potassium channel family. (614 aa)
	HOMER1	Homer scaffold protein 1. (377 aa)
	LOC103457606	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (994 aa)
	LOC103470867	Cytoplasmic polyadenylation element binding protein 4a. (741 aa)
	LOC103468563	Uncharacterized protein. (391 aa)
	gria1	Glutamate receptor, ionotropic, AMPA 1a. (826 aa)
	LOC103467373	Nuclear receptor subfamily 1, group D, member 4a. (585 aa)
	gria4	Glutamate receptor, ionotropic, AMPA 4a. (881 aa)
	ENSPREP00000031000	Shisa family member 8b. (471 aa)
	gria3	Glutamate receptor, ionotropic, AMPA 3a. (885 aa)
	NRGN	Neurogranin. (90 aa)
	ENSPREP00000032937	SH3 domain-containing protein. (87 aa)
	dock10	Dedicator of cytokinesis 10; Belongs to the DOCK family. (2188 aa)
	p2rx3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (415 aa)
	fxr1	Fragile X mental retardation, autosomal homolog 1. (571 aa)
	LOC103462423	Amyloid beta (A4) precursor protein-binding, family A, member 2b. (770 aa)
	dagla	Diacylglycerol lipase, alpha. (1105 aa)
	LOC103481795	Nerve growth factor receptor b. (354 aa)
	ENSPREP00000034105	Proline-rich transmembrane protein 2. (159 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABR	CDC42	ENSPREP00000008749	ENSPREP00000005959	ABR activator of RhoGEF and GTPase.	Cell division cycle 42.	0.446
ABR	LOC103465423	ENSPREP00000008749	ENSPREP00000026666	ABR activator of RhoGEF and GTPase.	Cell division cycle 42.	0.446
BAIAP2	CDC42	ENSPREP00000022196	ENSPREP00000005959	BAI1 associated protein 2.	Cell division cycle 42.	0.836
BAIAP2	ENSPREP00000032937	ENSPREP00000022196	ENSPREP00000032937	BAI1 associated protein 2.	SH3 domain-containing protein.	0.711
BAIAP2	LOC103465423	ENSPREP00000022196	ENSPREP00000026666	BAI1 associated protein 2.	Cell division cycle 42.	0.836
BAIAP2	LOC103468820	ENSPREP00000022196	ENSPREP00000004709	BAI1 associated protein 2.	BAI1-associated protein 2a.	0.901
BAIAP2	LOC103472837	ENSPREP00000022196	ENSPREP00000001820	BAI1 associated protein 2.	Uncharacterized protein.	0.722
BAIAP2	LOC103477991	ENSPREP00000022196	ENSPREP00000017385	BAI1 associated protein 2.	Uncharacterized protein.	0.722
BAIAP2	LOC103477993	ENSPREP00000022196	ENSPREP00000016909	BAI1 associated protein 2.	Uncharacterized protein.	0.722
Bcr	CDC42	ENSPREP00000024152	ENSPREP00000005959	Si:dkey-91m11.5.	Cell division cycle 42.	0.446
Bcr	ENSPREP00000024183	ENSPREP00000024152	ENSPREP00000024183	Si:dkey-91m11.5.	Rho-GAP domain-containing protein.	0.897
Bcr	LOC103465423	ENSPREP00000024152	ENSPREP00000026666	Si:dkey-91m11.5.	Cell division cycle 42.	0.446
CDC42	ABR	ENSPREP00000005959	ENSPREP00000008749	Cell division cycle 42.	ABR activator of RhoGEF and GTPase.	0.446
CDC42	BAIAP2	ENSPREP00000005959	ENSPREP00000022196	Cell division cycle 42.	BAI1 associated protein 2.	0.836
CDC42	Bcr	ENSPREP00000005959	ENSPREP00000024152	Cell division cycle 42.	Si:dkey-91m11.5.	0.446
CDC42	ENSPREP00000024183	ENSPREP00000005959	ENSPREP00000024183	Cell division cycle 42.	Rho-GAP domain-containing protein.	0.446
CDC42	ENSPREP00000032937	ENSPREP00000005959	ENSPREP00000032937	Cell division cycle 42.	SH3 domain-containing protein.	0.437
CDC42	LOC103457606	ENSPREP00000005959	ENSPREP00000028576	Cell division cycle 42.	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.492
CDC42	LOC103468820	ENSPREP00000005959	ENSPREP00000004709	Cell division cycle 42.	BAI1-associated protein 2a.	0.836
CDC42	LOC103472469	ENSPREP00000005959	ENSPREP00000017329	Cell division cycle 42.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.492