(18 nodes) Myelin sheath network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103471165	Proteolipid protein 1a. (254 aa)
	pllp	Plasmolipin. (183 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (385 aa)
	CNP	2',3'-cyclic nucleotide 3' phosphodiesterase. (653 aa)
	Cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (142 aa)
	LOC103464693	Tetraspanin. (195 aa)
	LOC103470677	MARVEL domain containing 2b. (556 aa)
	LOC103473180	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	LOC103457917	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1. (767 aa)
	HSP90AA1	Heat shock protein 90 alpha family class A member 1. (496 aa)
	mbp	Myelin basic protein b. (142 aa)
	LOC103473228	MARVEL domain containing 2a. (563 aa)
	cntn2	Contactin 2. (1034 aa)
	ENSPREP00000029699	Myelin protein zero. (284 aa)
	LOC103475755	Proteolipid protein 1b. (257 aa)
	LOC103468044	Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family. (197 aa)
	exoc4	Exocyst complex component 4. (994 aa)
	prkcz	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (608 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNP	LOC103471165	ENSPREP00000015684	ENSPREP00000010201	2',3'-cyclic nucleotide 3' phosphodiesterase.	Proteolipid protein 1a.	0.415
CNP	LOC103475755	ENSPREP00000015684	ENSPREP00000032312	2',3'-cyclic nucleotide 3' phosphodiesterase.	Proteolipid protein 1b.	0.415
CNP	mbp	ENSPREP00000015684	ENSPREP00000021220	2',3'-cyclic nucleotide 3' phosphodiesterase.	Myelin basic protein b.	0.600
CNP	sirt2	ENSPREP00000015684	ENSPREP00000012959	2',3'-cyclic nucleotide 3' phosphodiesterase.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.588
Cldn5	LOC103473180	ENSPREP00000017247	ENSPREP00000020548	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.658
ENSPREP00000029699	LOC103464693	ENSPREP00000029699	ENSPREP00000017615	Myelin protein zero.	Tetraspanin.	0.474
ENSPREP00000029699	LOC103471165	ENSPREP00000029699	ENSPREP00000010201	Myelin protein zero.	Proteolipid protein 1a.	0.486
ENSPREP00000029699	LOC103475755	ENSPREP00000029699	ENSPREP00000032312	Myelin protein zero.	Proteolipid protein 1b.	0.466
ENSPREP00000029699	pllp	ENSPREP00000029699	ENSPREP00000001115	Myelin protein zero.	Plasmolipin.	0.473
LOC103464693	ENSPREP00000029699	ENSPREP00000017615	ENSPREP00000029699	Tetraspanin.	Myelin protein zero.	0.474
LOC103464693	LOC103471165	ENSPREP00000017615	ENSPREP00000010201	Tetraspanin.	Proteolipid protein 1a.	0.526
LOC103464693	pllp	ENSPREP00000017615	ENSPREP00000001115	Tetraspanin.	Plasmolipin.	0.493
LOC103471165	CNP	ENSPREP00000010201	ENSPREP00000015684	Proteolipid protein 1a.	2',3'-cyclic nucleotide 3' phosphodiesterase.	0.415
LOC103471165	ENSPREP00000029699	ENSPREP00000010201	ENSPREP00000029699	Proteolipid protein 1a.	Myelin protein zero.	0.486
LOC103471165	LOC103464693	ENSPREP00000010201	ENSPREP00000017615	Proteolipid protein 1a.	Tetraspanin.	0.526
LOC103471165	mbp	ENSPREP00000010201	ENSPREP00000021220	Proteolipid protein 1a.	Myelin basic protein b.	0.713
LOC103471165	pllp	ENSPREP00000010201	ENSPREP00000001115	Proteolipid protein 1a.	Plasmolipin.	0.529
LOC103473180	Cldn5	ENSPREP00000020548	ENSPREP00000017247	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.658
LOC103475755	CNP	ENSPREP00000032312	ENSPREP00000015684	Proteolipid protein 1b.	2',3'-cyclic nucleotide 3' phosphodiesterase.	0.415
LOC103475755	ENSPREP00000029699	ENSPREP00000032312	ENSPREP00000029699	Proteolipid protein 1b.	Myelin protein zero.	0.466