(37 nodes) Response to alkaloid network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B. (170 aa)
	pcsk1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (782 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1239 aa)
	RYR3	Ryanodine receptor 3. (4810 aa)
	LOC103475680	Uncharacterized protein. (3513 aa)
	ENSPREP00000028754	Ins145_P3_rec domain-containing protein. (126 aa)
	HOMER1	Homer scaffold protein 1. (377 aa)
	slc1a2	Amino acid transporter. (537 aa)
	drd3	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (455 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (944 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (478 aa)
	ube3a	Ubiquitin protein ligase E3A. (823 aa)
	LOC103463031	Dopamine receptor D4a. (359 aa)
	ENSPREP00000023453	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (755 aa)
	recql5	RecQ helicase-like 5. (1020 aa)
	LOC103473757	Serine and arginine rich splicing factor 9. (251 aa)
	LOC103470076	Uncharacterized protein. (381 aa)
	LOC103468990	Amino acid transporter. (675 aa)
	ppp1r1b	Protein phosphatase 1, regulatory (inhibitor) subunit 1B. (239 aa)
	LOC103476718	Ryanodine receptor 2b (cardiac). (4826 aa)
	ENSPREP00000015626	Ins145_P3_rec domain-containing protein. (168 aa)
	ENSPREP00000015615	B30.2/SPRY domain-containing protein. (309 aa)
	LOC103481184	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1181 aa)
	SPIDR	Scaffold protein involved in DNA repair. (934 aa)
	cdk5	Cyclin-dependent kinase 5. (262 aa)
	blm	BLM RecQ like helicase. (1399 aa)
	abat	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
	ENSPREP00000005452	B30.2/SPRY domain-containing protein. (307 aa)
	LOC103462732	Amino acid transporter. (559 aa)
	LOC103470410	Homer scaffold protein 1b. (402 aa)
	ryr2	Uncharacterized protein. (4860 aa)
	casp6	Caspase 6, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (312 aa)
	LOC103467741	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1451 aa)
	rad51	RAD51 recombinase. (219 aa)
	drd4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (406 aa)
	LOC103457562	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1185 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000005452	ENSPREP00000015626	ENSPREP00000005452	ENSPREP00000015626	B30.2/SPRY domain-containing protein.	Ins145_P3_rec domain-containing protein.	0.926
ENSPREP00000005452	ENSPREP00000028754	ENSPREP00000005452	ENSPREP00000028754	B30.2/SPRY domain-containing protein.	Ins145_P3_rec domain-containing protein.	0.841
ENSPREP00000005452	LOC103475680	ENSPREP00000005452	ENSPREP00000028855	B30.2/SPRY domain-containing protein.	Uncharacterized protein.	0.913
ENSPREP00000015615	ENSPREP00000015626	ENSPREP00000015615	ENSPREP00000015626	B30.2/SPRY domain-containing protein.	Ins145_P3_rec domain-containing protein.	0.936
ENSPREP00000015615	ENSPREP00000028754	ENSPREP00000015615	ENSPREP00000028754	B30.2/SPRY domain-containing protein.	Ins145_P3_rec domain-containing protein.	0.799
ENSPREP00000015615	LOC103475680	ENSPREP00000015615	ENSPREP00000028855	B30.2/SPRY domain-containing protein.	Uncharacterized protein.	0.913
ENSPREP00000015626	ENSPREP00000005452	ENSPREP00000015626	ENSPREP00000005452	Ins145_P3_rec domain-containing protein.	B30.2/SPRY domain-containing protein.	0.926
ENSPREP00000015626	ENSPREP00000015615	ENSPREP00000015626	ENSPREP00000015615	Ins145_P3_rec domain-containing protein.	B30.2/SPRY domain-containing protein.	0.936
ENSPREP00000015626	LOC103475680	ENSPREP00000015626	ENSPREP00000028855	Ins145_P3_rec domain-containing protein.	Uncharacterized protein.	0.618
ENSPREP00000028754	ENSPREP00000005452	ENSPREP00000028754	ENSPREP00000005452	Ins145_P3_rec domain-containing protein.	B30.2/SPRY domain-containing protein.	0.841
ENSPREP00000028754	ENSPREP00000015615	ENSPREP00000028754	ENSPREP00000015615	Ins145_P3_rec domain-containing protein.	B30.2/SPRY domain-containing protein.	0.799
ENSPREP00000028754	LOC103475680	ENSPREP00000028754	ENSPREP00000028855	Ins145_P3_rec domain-containing protein.	Uncharacterized protein.	0.920
LOC103463031	drd3	ENSPREP00000025144	ENSPREP00000027769	Dopamine receptor D4a.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.660
LOC103475680	ENSPREP00000005452	ENSPREP00000028855	ENSPREP00000005452	Uncharacterized protein.	B30.2/SPRY domain-containing protein.	0.913
LOC103475680	ENSPREP00000015615	ENSPREP00000028855	ENSPREP00000015615	Uncharacterized protein.	B30.2/SPRY domain-containing protein.	0.913
LOC103475680	ENSPREP00000015626	ENSPREP00000028855	ENSPREP00000015626	Uncharacterized protein.	Ins145_P3_rec domain-containing protein.	0.618
LOC103475680	ENSPREP00000028754	ENSPREP00000028855	ENSPREP00000028754	Uncharacterized protein.	Ins145_P3_rec domain-containing protein.	0.920
LOC103476718	ryr2	ENSPREP00000015663	ENSPREP00000003466	Ryanodine receptor 2b (cardiac).	Uncharacterized protein.	0.901
PPP1R1B	cdk5	ENSPREP00000034263	ENSPREP00000011776	Protein phosphatase 1 regulatory inhibitor subunit 1B.	Cyclin-dependent kinase 5.	0.740
SPIDR	blm	ENSPREP00000012724	ENSPREP00000011311	Scaffold protein involved in DNA repair.	BLM RecQ like helicase.	0.640