(90 nodes) Regulation of protein binding network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103473180	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	ENSPREP00000020277	RBR-type E3 ubiquitin transferase. (158 aa)
	spon1	Spondin 1a. (806 aa)
	ttbk2	Tau tubulin kinase 2a. (1167 aa)
	bambi	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a. (278 aa)
	LOC103480677	FERM domain-containing protein. (656 aa)
	Cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (142 aa)
	grem2	Gremlin 2, DAN family BMP antagonist a. (192 aa)
	sppl3	Signal peptide peptidase 3. (383 aa)
	LOC103465217	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (159 aa)
	poldip2	Polymerase (DNA-directed), delta interacting protein 2. (377 aa)
	LOC103473017	Apolipoprotein Ea. (251 aa)
	BAX	BCL2 associated X, apoptosis regulator. (191 aa)
	LOC103468663	Uncharacterized protein. (200 aa)
	LOC103475650	Vitronectin b. (444 aa)
	mitd1	MIT, microtubule interacting and transport, domain containing 1. (180 aa)
	ENSPREP00000012632	MIT domain-containing protein. (55 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (156 aa)
	LOC103477155	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (560 aa)
	pkd1	Polycystic kidney disease 1a. (4592 aa)
	lrpap1	Low density lipoprotein receptor-related protein associated protein 1. (347 aa)
	ENSPREP00000001027	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (467 aa)
	ENSPREP00000001630	RHD domain-containing protein. (238 aa)
	Nfatc4	Uncharacterized protein. (238 aa)
	LOC103466243	Uncharacterized protein. (782 aa)
	Cav1	Uncharacterized protein. (84 aa)
	ide	Insulin-degrading enzyme; Belongs to the peptidase M16 family. (1064 aa)
	ldlrap1	Low density lipoprotein receptor adaptor protein 1b. (287 aa)
	styx	Serine/threonine/tyrosine interacting protein. (224 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2573 aa)
	il10	Interleukin 10. (229 aa)
	men1	Multiple endocrine neoplasia I. (627 aa)
	efhb	Uncharacterized protein. (593 aa)
	adnp	Activity-dependent neuroprotector homeobox b. (1057 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (193 aa)
	LOC103477848	Apolipoprotein Eb. (265 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (855 aa)
	ENSPREP00000007570	Uncharacterized protein. (131 aa)
	LOC103465701	Thymine DNA glycosylase, tandem duplicate 2. (438 aa)
	ENSPREP00000008452	Uncharacterized protein. (277 aa)
	ENSPREP00000008498	Uncharacterized protein. (286 aa)
	LOC103479045	Uncharacterized protein. (335 aa)
	sympk	Symplekin. (1220 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (582 aa)
	LOC103471866	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (308 aa)
	bmp4	Bone morphogenetic protein 4. (480 aa)
	LOC103457432	Tau tubulin kinase 2b. (429 aa)
	rapgef2	Rap guanine nucleotide exchange factor (GEF) 2. (1615 aa)
	nvl	Nuclear VCP like; Belongs to the AAA ATPase family. (670 aa)
	cdk5	Cyclin-dependent kinase 5. (262 aa)
	dtnbp1	Dystrobrevin binding protein 1b. (229 aa)
	ENSPREP00000012400	Uncharacterized protein. (550 aa)
	LOC103474638	Bone morphogenetic protein 16. (512 aa)
	bag2	BCL2 associated athanogene 2. (208 aa)
	LOC103465574	Inhibitor of DNA binding 1, HLH protein. (127 aa)
	LOC103467312	Zgc:66440. (395 aa)
	LOC103467314	RING-type domain-containing protein. (198 aa)
	gnl3l	Guanine nucleotide binding protein-like 3 (nucleolar)-like. (551 aa)
	vtn	Vitronectin a. (568 aa)
	pcsk9	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (671 aa)
	LOC103482005	E1A binding protein p300 a. (2743 aa)
	wfikkn2	Info WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2a. (575 aa)
	LOC103468546	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (220 aa)
	ENSPREP00000030224	PID domain-containing protein. (124 aa)
	tnfsf11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (268 aa)
	LOC108166784	Sperm associated antigen 8. (183 aa)
	ttbk1	Protein kinase domain-containing protein. (1261 aa)
	snapin	SNAP associated protein. (129 aa)
	psme3ip1	Family with sequence similarity 192 member A. (264 aa)
	ENSPREP00000027807	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (393 aa)
	LOC103481933	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2b. (576 aa)
	abl2	Tyrosine-protein kinase. (1187 aa)
	LOC103468460	E1A binding protein p300 b. (2737 aa)
	LOC103479906	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (407 aa)
	LOC103472050	Low density lipoprotein receptor adaptor protein 1a. (310 aa)
	LOC103469642	Si:dkey-3h3.3. (444 aa)
	pex14	Peroxisomal biogenesis factor 14. (374 aa)
	cthrc1	Collagen triple helix repeat containing 1b. (230 aa)
	sorl1	Sortilin-related receptor, L(DLR class) A repeats containing. (2086 aa)
	ctnnbip1	Catenin, beta interacting protein 1. (81 aa)
	ENSPREP00000022586	RING-type domain-containing protein. (205 aa)
	ENSPREP00000022564	RING-type domain-containing protein. (200 aa)
	ENSPREP00000022539	RING-type domain-containing protein. (198 aa)
	ENSPREP00000021691	Uncharacterized protein. (123 aa)
	LOC103464789	Tribbles pseudokinase 3. (351 aa)
	LOC103476799	Dickkopf WNT signaling pathway inhibitor 1a. (242 aa)
	abl1	Tyrosine-protein kinase. (1124 aa)
	derl1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (254 aa)
	dhrs7b	Dehydrogenase/reductase (SDR family) member 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (323 aa)
	ctsz	Cathepsin Z; Belongs to the peptidase C1 family. (306 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAX	LOC103468663	ENSPREP00000013021	ENSPREP00000012995	BCL2 associated X, apoptosis regulator.	Uncharacterized protein.	0.903
Cav1	Cldn5	ENSPREP00000003891	ENSPREP00000017247	Uncharacterized protein.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.468
Cav1	LOC103473180	ENSPREP00000003891	ENSPREP00000020548	Uncharacterized protein.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.468
Cav1	LOC103477848	ENSPREP00000003891	ENSPREP00000006664	Uncharacterized protein.	Apolipoprotein Eb.	0.418
Cldn5	Cav1	ENSPREP00000017247	ENSPREP00000003891	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.468
Cldn5	LOC103473180	ENSPREP00000017247	ENSPREP00000020548	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.658
ENSPREP00000001630	Nfatc4	ENSPREP00000001630	ENSPREP00000001665	RHD domain-containing protein.	Uncharacterized protein.	0.865
ENSPREP00000007570	LOC103468460	ENSPREP00000007570	ENSPREP00000026558	Uncharacterized protein.	E1A binding protein p300 b.	0.492
ENSPREP00000007570	LOC103482005	ENSPREP00000007570	ENSPREP00000030842	Uncharacterized protein.	E1A binding protein p300 a.	0.492
ENSPREP00000012400	dtnbp1	ENSPREP00000012400	ENSPREP00000012354	Uncharacterized protein.	Dystrobrevin binding protein 1b.	0.550
ENSPREP00000020277	cdk5	ENSPREP00000020277	ENSPREP00000011776	RBR-type E3 ubiquitin transferase.	Cyclin-dependent kinase 5.	0.442
ENSPREP00000020277	lrrk2	ENSPREP00000020277	ENSPREP00000005307	RBR-type E3 ubiquitin transferase.	Leucine-rich repeat kinase 2.	0.606
ENSPREP00000020277	ripk2	ENSPREP00000020277	ENSPREP00000009886	RBR-type E3 ubiquitin transferase.	Receptor-interacting serine-threonine kinase 2.	0.460
ENSPREP00000030224	LOC103472050	ENSPREP00000030224	ENSPREP00000025442	PID domain-containing protein.	Low density lipoprotein receptor adaptor protein 1a.	0.463
ENSPREP00000030224	LOC103476799	ENSPREP00000030224	ENSPREP00000021364	PID domain-containing protein.	Dickkopf WNT signaling pathway inhibitor 1a.	0.415
ENSPREP00000030224	ldlrap1	ENSPREP00000030224	ENSPREP00000004477	PID domain-containing protein.	Low density lipoprotein receptor adaptor protein 1b.	0.577
LOC103465701	LOC103468460	ENSPREP00000007806	ENSPREP00000026558	Thymine DNA glycosylase, tandem duplicate 2.	E1A binding protein p300 b.	0.492
LOC103465701	LOC103482005	ENSPREP00000007806	ENSPREP00000030842	Thymine DNA glycosylase, tandem duplicate 2.	E1A binding protein p300 a.	0.492
LOC103468460	ENSPREP00000007570	ENSPREP00000026558	ENSPREP00000007570	E1A binding protein p300 b.	Uncharacterized protein.	0.492
LOC103468460	LOC103465701	ENSPREP00000026558	ENSPREP00000007806	E1A binding protein p300 b.	Thymine DNA glycosylase, tandem duplicate 2.	0.492