(32 nodes) Negative regulation of MAP kinase activity network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cdk5rap3	CDK5 regulatory subunit associated protein 3. (506 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	Cav1	Uncharacterized protein. (84 aa)
	paqr3	Progestin and adipoQ receptor family member IIIa. (347 aa)
	LOC103477848	Apolipoprotein Eb. (265 aa)
	LOC103476580	Dual specificity phosphatase 19b. (202 aa)
	spry4	Sprouty homolog 4 (Drosophila). (283 aa)
	LOC103473559	Progestin and adipoQ receptor family member IIIb. (315 aa)
	spry1	Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (358 aa)
	bmp4	Bone morphogenetic protein 4. (480 aa)
	dusp10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (472 aa)
	ENSPREP00000012283	Axin interactor, dorsalization associated. (280 aa)
	LOC103476047	Sprouty RTK signaling antagonist 2. (349 aa)
	LOC103473017	Apolipoprotein Ea. (251 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
	LOC103465217	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (159 aa)
	agt	Angiotensinogen; Belongs to the serpin family. (452 aa)
	LOC103476207	Si:dkey-175m17.7. (913 aa)
	hmgcr	3-hydroxy-3-methylglutaryl coenzyme A reductase. (883 aa)
	SPRY3	Sprouty RTK signaling antagonist 3. (294 aa)
	sh2b3	SH2B adaptor protein 3. (710 aa)
	nf1	Neurofibromin 1b. (2742 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (602 aa)
	ENSPREP00000022871	PKD domain-containing protein. (262 aa)
	sorl1	Sortilin-related receptor, L(DLR class) A repeats containing. (2086 aa)
	ENSPREP00000026191	Glucosylceramidase. (147 aa)
	Gba	Glucosylceramidase. (291 aa)
	LOC103473284	3-hydroxy-3-methylglutaryl coenzyme A reductase. (873 aa)
	LOC103474475	Uncharacterized protein. (342 aa)
	ptpn5	Protein tyrosine phosphatase non-receptor type 5. (570 aa)
	dusp19	Dual specificity phosphatase 19a. (209 aa)
	LOC103474638	Bone morphogenetic protein 16. (512 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cav1	LOC103477848	ENSPREP00000003891	ENSPREP00000006664	Uncharacterized protein.	Apolipoprotein Eb.	0.418
Cav1	cav3	ENSPREP00000003891	ENSPREP00000013872	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.544
ENSPREP00000026191	Gba	ENSPREP00000026191	ENSPREP00000026205	Glucosylceramidase.	Glucosylceramidase.	0.926
Gba	ENSPREP00000026191	ENSPREP00000026205	ENSPREP00000026191	Glucosylceramidase.	Glucosylceramidase.	0.926
Gba	smpd1	ENSPREP00000026205	ENSPREP00000021479	Glucosylceramidase.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.	0.933
LOC103465217	cav3	ENSPREP00000013910	ENSPREP00000013872	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.955
LOC103473017	sorl1	ENSPREP00000013094	ENSPREP00000023592	Apolipoprotein Ea.	Sortilin-related receptor, L(DLR class) A repeats containing.	0.687
LOC103473284	hmgcr	ENSPREP00000027438	ENSPREP00000018171	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.901
LOC103476047	spry1	ENSPREP00000013063	ENSPREP00000009522	Sprouty RTK signaling antagonist 2.	Sprouty homolog 1, antagonist of FGF signaling (Drosophila).	0.624
LOC103477848	Cav1	ENSPREP00000006664	ENSPREP00000003891	Apolipoprotein Eb.	Uncharacterized protein.	0.418
LOC103477848	agt	ENSPREP00000006664	ENSPREP00000016816	Apolipoprotein Eb.	Angiotensinogen; Belongs to the serpin family.	0.487
LOC103477848	cav3	ENSPREP00000006664	ENSPREP00000013872	Apolipoprotein Eb.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.436
LOC103477848	hmgcr	ENSPREP00000006664	ENSPREP00000018171	Apolipoprotein Eb.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.456
LOC103477848	sorl1	ENSPREP00000006664	ENSPREP00000023592	Apolipoprotein Eb.	Sortilin-related receptor, L(DLR class) A repeats containing.	0.768
SPRY3	spry1	ENSPREP00000020192	ENSPREP00000009522	Sprouty RTK signaling antagonist 3.	Sprouty homolog 1, antagonist of FGF signaling (Drosophila).	0.570
agt	LOC103477848	ENSPREP00000016816	ENSPREP00000006664	Angiotensinogen; Belongs to the serpin family.	Apolipoprotein Eb.	0.487
cav3	Cav1	ENSPREP00000013872	ENSPREP00000003891	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.544
cav3	LOC103465217	ENSPREP00000013872	ENSPREP00000013910	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.955
cav3	LOC103477848	ENSPREP00000013872	ENSPREP00000006664	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Apolipoprotein Eb.	0.436
hmgcr	LOC103473284	ENSPREP00000018171	ENSPREP00000027438	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.901