(13 nodes) Dicarboxylic acid biosynthetic process network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	ENSPREP00000001718	Uncharacterized protein. (156 aa)
	LOC103461842	EF-hand_14 domain-containing protein. (563 aa)
	got1	Aspartate aminotransferase. (398 aa)
	GOT1	Aspartate aminotransferase. (463 aa)
	LOC103457187	Glutaminase a. (617 aa)
	mthfd1	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (934 aa)
	kynu	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (463 aa)
	LOC103464825	Glutaminase 2b (liver, mitochondrial). (514 aa)
	haao	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (287 aa)
	gls2	Glutaminase 2a (liver, mitochondrial). (600 aa)
	ENSPREP00000006896	2-epi-5-epi-valiolone synthase. (303 aa)
	mthfd1l	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (695 aa)
	kmo	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (480 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000006896	GOT1	ENSPREP00000006896	ENSPREP00000031324	2-epi-5-epi-valiolone synthase.	Aspartate aminotransferase.	0.408
ENSPREP00000006896	got1	ENSPREP00000006896	ENSPREP00000029105	2-epi-5-epi-valiolone synthase.	Aspartate aminotransferase.	0.408
ENSPREP00000006896	mthfd1	ENSPREP00000006896	ENSPREP00000032284	2-epi-5-epi-valiolone synthase.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b.	0.429
ENSPREP00000006896	mthfd1l	ENSPREP00000006896	ENSPREP00000005791	2-epi-5-epi-valiolone synthase.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.429
GOT1	ENSPREP00000006896	ENSPREP00000031324	ENSPREP00000006896	Aspartate aminotransferase.	2-epi-5-epi-valiolone synthase.	0.408
got1	ENSPREP00000006896	ENSPREP00000029105	ENSPREP00000006896	Aspartate aminotransferase.	2-epi-5-epi-valiolone synthase.	0.408
haao	kmo	ENSPREP00000015402	ENSPREP00000004178	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.893
haao	kynu	ENSPREP00000015402	ENSPREP00000032472	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.993
kmo	haao	ENSPREP00000004178	ENSPREP00000015402	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family.	0.893
kmo	kynu	ENSPREP00000004178	ENSPREP00000032472	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.999
kynu	haao	ENSPREP00000032472	ENSPREP00000015402	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family.	0.993
kynu	kmo	ENSPREP00000032472	ENSPREP00000004178	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.999
mthfd1	ENSPREP00000006896	ENSPREP00000032284	ENSPREP00000006896	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b.	2-epi-5-epi-valiolone synthase.	0.429
mthfd1	mthfd1l	ENSPREP00000032284	ENSPREP00000005791	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.901
mthfd1l	ENSPREP00000006896	ENSPREP00000005791	ENSPREP00000006896	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	2-epi-5-epi-valiolone synthase.	0.429
mthfd1l	mthfd1	ENSPREP00000005791	ENSPREP00000032284	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b.	0.901