(27 nodes) Main axon network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103462732	Amino acid transporter. (559 aa)
	c9orf72	Zgc:100846. (298 aa)
	LOC103464471	Tumor necrosis factor receptor superfamily, member 1B. (441 aa)
	kcnab2	Potassium voltage-gated channel subfamily A regulatory beta subunit 2. (527 aa)
	PARD3	Par-3 family cell polarity regulator. (1383 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (385 aa)
	scn1b	Sodium channel, voltage-gated, type I, beta b. (223 aa)
	LOC103468990	Amino acid transporter. (675 aa)
	Cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (142 aa)
	LOC103464711	Neuron navigator 1b. (1719 aa)
	LOC103470076	Uncharacterized protein. (381 aa)
	LOC103473180	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	mbp	Myelin basic protein b. (142 aa)
	ENSPREP00000024427	IGv domain-containing protein. (354 aa)
	LOC103479385	Potassium voltage-gated channel, shaker-related subfamily, beta member 1 b. (417 aa)
	KCNAB1	Potassium voltage-gated channel subfamily A member regulatory beta subunit 1. (428 aa)
	ENSPREP00000025758	Peptidase S72 domain-containing protein. (799 aa)
	ucn	Urotensin 1. (147 aa)
	pard3	Par-3 family cell polarity regulator alpha, b. (1384 aa)
	hapln2	Hyaluronan and proteoglycan link protein 2. (345 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
	slc1a2	Amino acid transporter. (537 aa)
	cntn2	Contactin 2. (1034 aa)
	NAV1	Neuron navigator 1. (2275 aa)
	dag1	Dystroglycan 1. (893 aa)
	dagla	Diacylglycerol lipase, alpha. (1105 aa)
	KCNAB3	Potassium voltage-gated channel subfamily A regulatory beta subunit 3. (438 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cldn5	LOC103473180	ENSPREP00000017247	ENSPREP00000020548	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.658
Cldn5	PARD3	ENSPREP00000017247	ENSPREP00000008904	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Par-3 family cell polarity regulator.	0.650
Cldn5	pard3	ENSPREP00000017247	ENSPREP00000027405	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Par-3 family cell polarity regulator alpha, b.	0.650
ENSPREP00000024427	scn1b	ENSPREP00000024427	ENSPREP00000013607	IGv domain-containing protein.	Sodium channel, voltage-gated, type I, beta b.	0.910
ENSPREP00000025758	dag1	ENSPREP00000025758	ENSPREP00000031725	Peptidase S72 domain-containing protein.	Dystroglycan 1.	0.901
LOC103470076	ucn	ENSPREP00000018881	ENSPREP00000027175	Uncharacterized protein.	Urotensin 1.	0.790
LOC103473180	Cldn5	ENSPREP00000020548	ENSPREP00000017247	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.658
LOC103473180	PARD3	ENSPREP00000020548	ENSPREP00000008904	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Par-3 family cell polarity regulator.	0.650
LOC103473180	pard3	ENSPREP00000020548	ENSPREP00000027405	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Par-3 family cell polarity regulator alpha, b.	0.650
PARD3	Cldn5	ENSPREP00000008904	ENSPREP00000017247	Par-3 family cell polarity regulator.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.650
PARD3	LOC103473180	ENSPREP00000008904	ENSPREP00000020548	Par-3 family cell polarity regulator.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.650
PARD3	pard3	ENSPREP00000008904	ENSPREP00000027405	Par-3 family cell polarity regulator.	Par-3 family cell polarity regulator alpha, b.	0.902
crhbp	ucn	ENSPREP00000027732	ENSPREP00000027175	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	Urotensin 1.	0.790
dag1	ENSPREP00000025758	ENSPREP00000031725	ENSPREP00000025758	Dystroglycan 1.	Peptidase S72 domain-containing protein.	0.901
pard3	Cldn5	ENSPREP00000027405	ENSPREP00000017247	Par-3 family cell polarity regulator alpha, b.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.650
pard3	LOC103473180	ENSPREP00000027405	ENSPREP00000020548	Par-3 family cell polarity regulator alpha, b.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.650
pard3	PARD3	ENSPREP00000027405	ENSPREP00000008904	Par-3 family cell polarity regulator alpha, b.	Par-3 family cell polarity regulator.	0.902
scn1b	ENSPREP00000024427	ENSPREP00000013607	ENSPREP00000024427	Sodium channel, voltage-gated, type I, beta b.	IGv domain-containing protein.	0.910
ucn	LOC103470076	ENSPREP00000027175	ENSPREP00000018881	Urotensin 1.	Uncharacterized protein.	0.790
ucn	crhbp	ENSPREP00000027175	ENSPREP00000027732	Urotensin 1.	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	0.790