(93 nodes) Regulated exocytosis network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103472577	Uncharacterized protein. (1105 aa)
	ENSPREP00000000351	Complexin 2, like. (134 aa)
	LOC103465435	Synaptogyrin. (242 aa)
	syt4	Synaptotagmin IV. (471 aa)
	LOC103466244	Synaptotagmin IXb. (529 aa)
	stx1a	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (368 aa)
	LOC103474679	RAB guanine nucleotide exchange factor (GEF) 1, like. (508 aa)
	LOC103469661	Syntaxin 2b; Belongs to the syntaxin family. (293 aa)
	LOC103468887	Uncharacterized protein. (267 aa)
	rab11fip2	RAB11 family interacting protein 2 (class I). (472 aa)
	SYT8	Synaptotagmin 8. (444 aa)
	LOC103468849	Synaptogyrin. (217 aa)
	LOC103469794	Uncharacterized protein. (1517 aa)
	cadps	Ca2+-dependent activator protein for secretion b. (1329 aa)
	ENSPREP00000004746	V-SNARE coiled-coil homology domain-containing protein. (94 aa)
	STX11	Syntaxin 11. (295 aa)
	LOC103457516	t-SNARE coiled-coil homology domain-containing protein. (296 aa)
	ENSPREP00000005740	PDZ domain-containing protein. (394 aa)
	LOC103459282	ELKS/RAB6-interacting/CAST family member 1. (1157 aa)
	LOC103467654	Synaptotagmin IIa. (430 aa)
	LOC103458407	Rap guanine nucleotide exchange factor (GEF) 4. (917 aa)
	LOC103457483	Otoferlin a. (1904 aa)
	Unc13b	Uncharacterized protein. (3189 aa)
	UNC13C	Unc-13 homolog C. (2664 aa)
	ENSPREP00000008454	C2 domain-containing protein. (216 aa)
	LOC103466664	Synaptotagmin Ib. (387 aa)
	CPLX1	Complexin 1. (133 aa)
	RABGEF1	RAB guanine nucleotide exchange factor 1. (291 aa)
	ENSPREP00000009573	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (140 aa)
	LOC103458179	RAB11 family interacting protein 5a (class I). (1442 aa)
	LOC103470525	Uncharacterized protein. (1229 aa)
	CADPS2	Calcium dependent secretion activator 2. (1241 aa)
	snap47	Synaptosome associated protein 47. (397 aa)
	cdk5	Cyclin-dependent kinase 5. (262 aa)
	cplx3	Complexin 3b. (156 aa)
	p2rx1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (421 aa)
	LOC103462615	C2 domain-containing protein. (380 aa)
	erc2	ELKS/RAB6-interacting/CAST family member 2. (1137 aa)
	unc13a	Uncharacterized protein. (1552 aa)
	LOC103481621	Synaptotagmin XV. (304 aa)
	rims1	Regulating synaptic membrane exocytosis 1a. (1422 aa)
	snap29	Synaptosome associated protein 29. (258 aa)
	syt3	Synaptotagmin III. (558 aa)
	rab11fip1	Uncharacterized protein. (1299 aa)
	LOC103466506	Synaptotagmin VIIa. (606 aa)
	ENSPREP00000017645	Uncharacterized protein. (191 aa)
	LOC103468304	Synaptotagmin Va. (434 aa)
	syt12	Synaptotagmin XII. (423 aa)
	SYT2	Synaptotagmin 2. (413 aa)
	stx1b	Syntaxin 1B; Belongs to the syntaxin family. (312 aa)
	LOC103470076	Uncharacterized protein. (381 aa)
	LOC103472500	Transmembrane protein 79a. (341 aa)
	STX19	Syntaxin 19. (303 aa)
	snap23	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (229 aa)
	p2rx7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (580 aa)
	ENSPREP00000019657	Uncharacterized protein. (253 aa)
	LOC103471510	Uncharacterized protein. (1440 aa)
	LOC103462870	Synaptotagmin IXa. (559 aa)
	LOC103481737	Syntaxin 4; Belongs to the syntaxin family. (294 aa)
	ENSPREP00000021283	t-SNARE coiled-coil homology domain-containing protein. (318 aa)
	Cplx2	Complexin 2. (227 aa)
	plek	Pleckstrin. (351 aa)
	otof	Otoferlin b. (1641 aa)
	LOC103482420	Prostaglandin D2 synthase b, tandem duplicate 1; Belongs to the calycin superfamily. Lipocalin family. (198 aa)
	stx11	Syntaxin 11a; Belongs to the syntaxin family. (288 aa)
	erc1	ELKS/RAB6-interacting/CAST family member 1a. (1115 aa)
	tmem79	Transmembrane protein 79b. (369 aa)
	RIMS2	Regulating synaptic membrane exocytosis 2. (1303 aa)
	LOC103457071	Fer-1 like family member 6. (1480 aa)
	syt11	Synaptotagmin XIb. (468 aa)
	stx3	Syntaxin 3A; Belongs to the syntaxin family. (323 aa)
	LOC103479452	Unc-13 homolog A. (1870 aa)
	cplx4	Complexin 4a. (159 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
	ERC2	Uncharacterized protein. (669 aa)
	snap25	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (204 aa)
	SYNGR3	Synaptogyrin. (230 aa)
	snapin	SNAP associated protein. (129 aa)
	LOC103465473	Ca2+-dependent activator protein for secretion a. (1254 aa)
	LOC103475417	Zgc:153704; Belongs to the calycin superfamily. Lipocalin family. (182 aa)
	LOC103467834	Synaptotagmin VIa. (541 aa)
	sdf4	Stromal cell derived factor 4. (373 aa)
	LOC103472178	Regulating synaptic membrane exocytosis 3. (323 aa)
	LOC103482050	Uncharacterized protein. (215 aa)
	LOC103480193	SCY domain-containing protein. (93 aa)
	LOC103481238	Synaptotagmin Vb. (424 aa)
	LOC103470421	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (285 aa)
	vamp7	Synaptobrevin-like 1; Belongs to the synaptobrevin family. (220 aa)
	syt1	Synaptotagmin Ia. (422 aa)
	syt10	Synaptotagmin X. (434 aa)
	stxbp3	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
	LOC103462425	Synaptotagmin VIIb. (468 aa)
	ENSPREP00000034105	Proline-rich transmembrane protein 2. (159 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPLX1	ENSPREP00000009573	ENSPREP00000008723	ENSPREP00000009573	Complexin 1.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.443
CPLX1	snap25	ENSPREP00000008723	ENSPREP00000028419	Complexin 1.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.523
Cplx2	ENSPREP00000004746	ENSPREP00000022098	ENSPREP00000004746	Complexin 2.	V-SNARE coiled-coil homology domain-containing protein.	0.434
Cplx2	ENSPREP00000005740	ENSPREP00000022098	ENSPREP00000005740	Complexin 2.	PDZ domain-containing protein.	0.473
Cplx2	ENSPREP00000008454	ENSPREP00000022098	ENSPREP00000008454	Complexin 2.	C2 domain-containing protein.	0.507
Cplx2	ENSPREP00000009573	ENSPREP00000022098	ENSPREP00000009573	Complexin 2.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.531
Cplx2	ENSPREP00000021283	ENSPREP00000022098	ENSPREP00000021283	Complexin 2.	t-SNARE coiled-coil homology domain-containing protein.	0.467
Cplx2	LOC103457516	ENSPREP00000022098	ENSPREP00000005732	Complexin 2.	t-SNARE coiled-coil homology domain-containing protein.	0.467
Cplx2	LOC103469661	ENSPREP00000022098	ENSPREP00000002499	Complexin 2.	Syntaxin 2b; Belongs to the syntaxin family.	0.467
Cplx2	LOC103469794	ENSPREP00000022098	ENSPREP00000003533	Complexin 2.	Uncharacterized protein.	0.507
Cplx2	LOC103470421	ENSPREP00000022098	ENSPREP00000032381	Complexin 2.	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	0.467
Cplx2	LOC103472178	ENSPREP00000022098	ENSPREP00000031671	Complexin 2.	Regulating synaptic membrane exocytosis 3.	0.475
Cplx2	LOC103472577	ENSPREP00000022098	ENSPREP00000023069	Complexin 2.	Uncharacterized protein.	0.960
Cplx2	LOC103479452	ENSPREP00000022098	ENSPREP00000026194	Complexin 2.	Unc-13 homolog A.	0.507
Cplx2	LOC103481737	ENSPREP00000022098	ENSPREP00000019745	Complexin 2.	Syntaxin 4; Belongs to the syntaxin family.	0.467
Cplx2	RIMS2	ENSPREP00000022098	ENSPREP00000023895	Complexin 2.	Regulating synaptic membrane exocytosis 2.	0.960
Cplx2	STX11	ENSPREP00000022098	ENSPREP00000005703	Complexin 2.	Syntaxin 11.	0.467
Cplx2	STX19	ENSPREP00000022098	ENSPREP00000019046	Complexin 2.	Syntaxin 19.	0.466
Cplx2	UNC13C	ENSPREP00000022098	ENSPREP00000008426	Complexin 2.	Unc-13 homolog C.	0.507
Cplx2	Unc13b	ENSPREP00000022098	ENSPREP00000008315	Complexin 2.	Uncharacterized protein.	0.507