(57 nodes) Meiotic chromosome segregation network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	espl1	Extra spindle pole bodies like 1, separase. (2165 aa)
	slx4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1463 aa)
	Sirt7	Uncharacterized protein. (134 aa)
	LOC103464578	Synaptonemal complex central element protein 2. (186 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (726 aa)
	ccdc36	Uncharacterized protein. (429 aa)
	smc4	Structural maintenance of chromosomes 4. (1155 aa)
	cenpx	Centromere protein X. (74 aa)
	bag6	BCL2 associated athanogene 6. (1194 aa)
	ENSPREP00000006667	Zebrafish testis-expressed 38. (320 aa)
	ccnb1ip1	Cyclin B1 interacting protein 1. (239 aa)
	spata22	Spermatogenesis associated 22. (382 aa)
	sgo1	Shugoshin_C domain-containing protein. (585 aa)
	shoc1	Uncharacterized protein. (1440 aa)
	ankle1	Zgc:85936. (834 aa)
	hfm1	Helicase for meiosis 1. (1062 aa)
	spo11	SPO11 initiator of meiotic double stranded breaks. (379 aa)
	tex11	Testis expressed 11. (770 aa)
	fancd2	FA complementation group D2. (1432 aa)
	mlh3	MutL homolog 3 (E. coli). (1117 aa)
	meioc	Uncharacterized protein. (822 aa)
	LOC103481653	Uncharacterized protein. (877 aa)
	msh4	MutS homolog 4. (848 aa)
	ndc1	NDC1 transmembrane nucleoporin. (669 aa)
	mei4	Meiotic double-stranded break formation protein 4. (376 aa)
	smc2	Structural maintenance of chromosomes protein. (1200 aa)
	pttg1	Uncharacterized protein. (177 aa)
	rad51c	RAD51 paralog C. (377 aa)
	top2b	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1604 aa)
	C1orf146	Chromosome 1 open reading frame 146. (172 aa)
	Bub1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (210 aa)
	ENSPREP00000021048	BUB1 N-terminal domain-containing protein. (264 aa)
	terb1	Telomere repeat binding bouquet formation protein 1. (804 aa)
	ttk	Ttk protein kinase. (996 aa)
	ncaph	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (696 aa)
	meiob	Methionine sulfoxide reductase B1b. (464 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (616 aa)
	ENSPREP00000023462	Uncharacterized protein. (132 aa)
	atm	Non-specific serine/threonine protein kinase. (3091 aa)
	ercc4	Excision repair cross-complementation group 4. (893 aa)
	dmc1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (343 aa)
	LOC103482091	Essential meiotic structure-specific endonuclease 1. (232 aa)
	rec8	REC8 meiotic recombination protein b. (566 aa)
	msh5	MutS homolog 5. (816 aa)
	terf1	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (367 aa)
	ccne2	Cyclin E2; Belongs to the cyclin family. (394 aa)
	EME2	ERCC4 domain-containing protein. (370 aa)
	rmi1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (671 aa)
	hormad1	HORMA domain containing 1. (372 aa)
	fancm	Uncharacterized protein. (1901 aa)
	Syce3	Uncharacterized protein. (81 aa)
	majin	Membrane anchored junction protein. (217 aa)
	nuf2	UF2 component of NDC80 kinetochore complex. (449 aa)
	top2a	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1577 aa)
	trip13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (414 aa)
	bub1b	BUB1 mitotic checkpoint serine/threonine kinase Bb. (427 aa)
	terb2	Telomere repeat binding bouquet formation protein 2. (222 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bub1	ENSPREP00000021048	ENSPREP00000021030	ENSPREP00000021048	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BUB1 N-terminal domain-containing protein.	0.847
Bub1	bub1b	ENSPREP00000021030	ENSPREP00000032059	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BUB1 mitotic checkpoint serine/threonine kinase Bb.	0.986
Bub1	dmc1	ENSPREP00000021030	ENSPREP00000025114	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.623
Bub1	espl1	ENSPREP00000021030	ENSPREP00000024176	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Extra spindle pole bodies like 1, separase.	0.894
Bub1	fancd2	ENSPREP00000021030	ENSPREP00000014095	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	FA complementation group D2.	0.401
Bub1	ncaph	ENSPREP00000021030	ENSPREP00000022711	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.	0.768
Bub1	nuf2	ENSPREP00000021030	ENSPREP00000030246	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	UF2 component of NDC80 kinetochore complex.	0.953
Bub1	pttg1	ENSPREP00000021030	ENSPREP00000018157	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.741
Bub1	rad51c	ENSPREP00000021030	ENSPREP00000019301	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	RAD51 paralog C.	0.623
Bub1	sgo1	ENSPREP00000021030	ENSPREP00000009459	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Shugoshin_C domain-containing protein.	0.944
Bub1	smc2	ENSPREP00000021030	ENSPREP00000017468	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Structural maintenance of chromosomes protein.	0.564
Bub1	smc4	ENSPREP00000021030	ENSPREP00000002936	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Structural maintenance of chromosomes 4.	0.604
Bub1	top2a	ENSPREP00000021030	ENSPREP00000030320	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.568
Bub1	top2b	ENSPREP00000021030	ENSPREP00000019999	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.568
Bub1	trip13	ENSPREP00000021030	ENSPREP00000031148	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	0.605
Bub1	ttk	ENSPREP00000021030	ENSPREP00000022549	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Ttk protein kinase.	0.941
C1orf146	hfm1	ENSPREP00000020884	ENSPREP00000011632	Chromosome 1 open reading frame 146.	Helicase for meiosis 1.	0.541
C1orf146	msh4	ENSPREP00000020884	ENSPREP00000016251	Chromosome 1 open reading frame 146.	MutS homolog 4.	0.512
C1orf146	msh5	ENSPREP00000020884	ENSPREP00000026457	Chromosome 1 open reading frame 146.	MutS homolog 5.	0.441
C1orf146	tex11	ENSPREP00000020884	ENSPREP00000013731	Chromosome 1 open reading frame 146.	Testis expressed 11.	0.432